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Fig. 1 | Molecular Cancer

Fig. 1

From: hsa_circ_0007919 induces LIG1 transcription by binding to FOXA1/TET1 to enhance the DNA damage response and promote gemcitabine resistance in pancreatic ductal adenocarcinoma

Fig. 1

hsa_circ_0007919 is upregulated in GEM-resistant PDAC and predicts poor prognosis

(A) Hierarchical clustering showing differentially expressed circRNAs in GEM-sensitive and GEM-resistant PDAC tissues (FC > 1 or <-1, p < 0.05). (B) The relative expression of hsa_circ_0007919 in GEM-sensitive and GEM-resistant PDAC tissues and corresponding adjacent PDAC tissues. (C) The relative expression of hsa_circ_0007919 in PDAC cells and normal pancreatic cells. (D) The genomic location and back-splicing of hsa_circ_0007919. (E) The splicing site of hsa_circ_0007919 validated by Sanger-seq. (F) PCR and agarose gel electrophoresis analysis of the presence of hsa_circ_0007919 and ABR in cDNA and gDNA samples from PDAC cells. (G) Expression of hsa_circ_0007919 and ABR in PDAC cells with or without RNase R treatment. (H-I) Kaplan–Meier analysis of the OS rate and DFS rate in PDAC patients with high or low expression of hsa_circ_0007919. (J-K) Kaplan–Meier analysis of the OS rate and DFS rate in GEM-resistant PDAC patients with high or low expression of hsa_circ_0007919. Data are the means ± SDs (n = 3 independent experiments), * p < 0.05, ** p < 0.01, *** p < 0.001

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Molecular Cancer

ISSN: 1476-4598