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Fig. 2 | Molecular Cancer

Fig. 2

From: hsa_circ_0007919 induces LIG1 transcription by binding to FOXA1/TET1 to enhance the DNA damage response and promote gemcitabine resistance in pancreatic ductal adenocarcinoma

Fig. 2

hsa_circ_0007919 inhibits gemcitabine sensitivity and apoptosis of GEM-resistant PDAC cells

(A-B) CCK-8 analysis of the sensitivity of PDAC cells with or without hsa_circ_0007919 inhibition under different concentrations of GEM. (C-D) CCK-8 analysis of the sensitivity of normal and GEM-resistant PDAC cells under different concentrations of GEM. (E) Expression of hsa_circ_0007919 in normal and PDAC-resistant PDAC cells. (F-G) CCK-8 analysis of the proliferation of GEM-resistant PDAC cells with or without hsa_circ_0007919 inhibition. (H-I) CCK-8 analysis of the proliferation of PDAC cells with or without hsa_circ_0007919 overexpression under GEM treatment condition. (J) Flow cytometry analysis of the apoptotic rate of PDAC-resistant PDAC cells with or without hsa_circ_0007919 inhibition. (K) Flow cytometry analysis of the apoptotic rate of PDAC PDAC cells with or without hsa_circ_0007919 overexpression under GEM treatment condition. (L-M) Expression of apoptosis-related proteins in GEM-resistant PDAC cells with or without hsa_circ_0007919 inhibition. (N-O) Expression of apoptosis-related proteins in GEM PDAC cells with or without hsa_circ_0007919 overexpression under GEM treatment condition. Data are the means ± SDs (n = 3 independent experiments), ** p < 0.01, *** p < 0.001

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Molecular Cancer

ISSN: 1476-4598