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Fig. 4 | Molecular Cancer

Fig. 4

From: hsa_circ_0007919 induces LIG1 transcription by binding to FOXA1/TET1 to enhance the DNA damage response and promote gemcitabine resistance in pancreatic ductal adenocarcinoma

Fig. 4

hsa_circ_0007919 inhibits DNA damage through LIG1-mediated repair pathways

(A) Hierarchical clustering showing differentially expressed genes in GEM-resistant PDAC cells with or without hsa_circ_0007919 inhibition (FC > 1 or < -1, p < 0.05). (B) KEGG enrichment analysis of hsa_circ_0007919-regulated gene expression events. (C-E) GSEA enrichment analysis of hsa_circ_0007919-regulated gene expression events. (F) Venn diagram showing overlapped genes between differentially expressed genes from base excision repair, mismatch repair and nucleotide excision repair pathways. (G-H) Expression of LIG1 in GEM-sensitive and -resistant PDAC tissues at mRNA and protein level (400×). (I) Correlation analysis of hsa_circ_0007919 and LIG1 expression in GEM-resistant tissues. (J-M) Expression of LIG1 in GEM-resistant cells with or without hsa_circ_0007919 inhibition at mRNA and protein level. Data are the means ± SDs (n = 3 independent experiments), ** p < 0.01

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Molecular Cancer

ISSN: 1476-4598