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Fig. 8 | Molecular Cancer

Fig. 8

From: CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis

Fig. 8

CircHERC1 promotes tumor proliferation and metastasis in vivo. (a) Representative images of tumor xenograft mouse models injected with NCI-H3255 cells transfected with the control vector, the circHERC1 overexpression vector, or the HMGB1 knockdown vector and cotransfected with the circHERC1 overexpression vector and the HMGB1 knockdown vector; the circHERC1 overexpression vector and the FOXO1 knockdown vector; or the circHERC1 overexpression vector, the HMGB1 knockdown vector, and the FOXO1 knockdown vector. (b) Weights of xenograft tumors in mice injected with NCI-H3255 at the endpoint. *p < 0.05, **p < 0.01. (c) Growth curve of tumor volume. *p < 0.05, **p < 0.01. (d) IHC staining of FOXO1 in xenograft tumors. The scale bars are 25 μm. (e) IHC staining of HMGB1 on a lung cancer tissue microarray (R121Lu01, Bioaitech, China). (f) Representative images of nude mice injected with the treated-NCI-H3255 cells mentioned above through the tail vein

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Molecular Cancer

ISSN: 1476-4598