Table 1 The Role of Trogocytosis in NK Cells Fate and Function

NKG2DLs

Cancer cells to NK cells

Downregulates NKG2D and increases NK cell fratricide

[23, 27]

m157

Cancer cells to NK cells

Reduces cytotoxic function and decreases IFN-γ production

[32,33,34]

PD-1

Cancer cells to NK cells

Reduces NK cell-mediated antitumor immunity

[35]

HLA-G1

Cancer cells to NK cells

Promotes acquisition of suppressive function by NK cells that prevents cytotoxic function of other NK cells.

[39]

MHC II and/or CD80/CD86

Dendritic cells to NK cells

Suppress T cell-mediated immune response through the lack of functional levels of costimulatory molecules in DC-dressed NK cells

[40]

CCR7

Dendritic cells (DCs) and T-cell blasts to NK cells

Promotes migration to lymph nodes

[44] [45]

CD9

Cancer cells to NK cells

Facilitates immune escape of intratumoral CD9-dressed NK cells, particularly through reduced antitumor cytokine production and increased pro-angiogenic IL-8

[46,47,48,49]