Outsmarting trogocytosis to boost CAR NK/T cell therapy

Table 2 The Role of Trogocytosis in T Cells Fate and Function

Trogocytic molecules/receptors	Direction	Effects on T cells fate and/or function	References
Costimulatory molecules	APCs to T cells	Controls T cell activation	[52, 56, 57, 61,62,63,64]
CD86	APCs to T cells	Modifies the function and phenotype of immune effector cells, resulting in the development of regulatory capabilities that inhibit the proliferation of other T cells	[71]
CD80/CD86	APCs to Treg cells	Promotes APCs and Tregs suppressive functions	[72]
CD1d	Target cells to γσ T cells	Promotes glycolipid antigen presentation to invariant natural killer T cells (iNKT)	[66]
MHC:peptide complexes	APCs to T cells	Reduce T cell effector functions and cytokine production by promoting activation-induced cell death or clonal exhaustion	[67]
CD137	Cancer cells to APCs	Reduces T cell costimulation capacity and proinflammatory cytokine release	[69, 70]
HLA-G	Cancer cells to T cells	Converts effector T cells into iTregs	[71]

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