CDK5: an oncogene or an anti-oncogene: location location location

Nikhil, Kumar; Shah, Kavita

doi:10.1186/s12943-023-01895-8

Molecular Cancer

Table 2 Direct CDK5 substrates in various cancer types

From: CDK5: an oncogene or an anti-oncogene: location location location

No	Substrate	Cancer Types	Phosphorylation sites	Protein type	Function	References
1	FAK	Breast cancer	S732	Kinase	Chemotaxis and invasion	[42]
2	PPARγ	Breast cancer	S273	Transcription factor	Metastasis and stemness	[43]
3	ADD1	Breast cancer	T724	Actin-binding protein	Cell migration and invasion	[44]
4	Talin	Breast cancer	S425	Cytoskeletal protein	Migration	[45]
5	PIPKIγ90	Breast cancer	S453	Kinase	Chemotaxis and invasion	[46]
6	FOXO1	Breast cancer	S249	Transcription factor	Inhibits apoptosis	[49]
7	AR	Prostate cancer	S81	Transcription factor	Proliferation	[50]
8	AR	Prostate cancer	S308	Transcription factor	Unknown	[54]
9	STAT3	Prostate cancer	S727	Transcription factor	Proliferation	[55]
10	p21CIP	Prostate cancer	S130	CDK inhibitor	Proliferation	[56]
11	Talin 1 (Talin)	Prostate cancer	S425	Cytoskeletal protein	Invasion	[57]
12	Rb	Prostate cancer	S807, S811	Tumor suppressor	Neuroendocrine Differentiation	[58]
13	EZH2	Pancreatic Cancer	T261	Histone-lysine N-methyltransferase	Inhibits migration and invasion	[61]
14	Rb	MTC	S807, S811	Tumor suppressor	Proliferation	[34]
15	STAT3	MTC	S727	Transcription factor	Proliferation and Tumorigenesis	[62, 63]
16	ERK5	Colorectal cancer	T732	Kinase	Proliferation	[66]
17	CRMP-2	Glioblastoma	S522	Axonal growth and guidance protein	Proliferation	[70]
18	PIKE-A	Glioblastoma	S249, S279	GTPase	Proliferation and migration	[71]
19	TRIM59	Glioblastoma	S308	E3 ubiquitin ligase	Tumorigenesis	[72]
20	Cortactin	Glioblastoma	T145, T219	F-actin-binding protein	Migration	[73]
21	ACSS2	Glioblastoma	S267	Metabolic enzyme	Tumorigenesis	[74]
22	DRP1	Glioblastoma	S616	GTPase	Mitochondrial fission	[76]
23	TPX2	HCC	S486	Spindle assembly factors	Protein stability and metastasis	[80]
23	HIF-1α	HCC	S687	Hypoxia inducible factors	Angiogenesis	[83]
24	PRMT1	HCC	S307	Arginine methyltransferase	Tumorigenesis	[84]
25	VEGFR2	Pituitary Adenoma	S229	Tyrosine kinase receptor	Invasion and metastasis	[86]
26	CAP1	Lung cancer	S308 and S310	Actin-binding protein	Proliferation, migration and invasion	[91, 92]
27	DLC-1	Lung cancer	S120, S205, S422, S509	Tumor suppressor	Inhibits tumorigenesis	[96]
28	Vimentin	Melanoma	S56	Cytoskeletal protein	Invasion and metastasis	[101]
29	NOXA	Leukemia	S13	Pro-apoptotic factor	Proliferation and survival	[112]

Talin is known to be phosphorylated by CDK5 in both breast and prostate cancer. STAT3 and Rb are phosphorylated by CDK5 in prostate cancer and MTC

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ISSN: 1476-4598

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