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Fig. 3 | Molecular Cancer

Fig. 3

From: The Impact of FGFR3 Alterations on the Tumor Microenvironment and the Efficacy of Immune Checkpoint Inhibitors in Bladder Cancer

Fig. 3

Different Pathways Modified by aFGFR3 between NMIBC and MIBC. A Principal component analysis for whole transcriptome data in iFGFR3 and aFGFR3. B Gene set enrichment analysis plotting all human MSigDB collections (Hallmark, C1-8: 23,734 gene sets) by false discovery rate q-value (FDR-q) and normalized enrichment score (NES). The analysis was performed separately in NMIBC (left panel) and MIBC (right panel). C Top 10 gene sets upregulated in MIBC/aFGFR3 (n = 39) compared to MIBC/iFGFR3 (n = 226). D mRNA expression levels in putative basal markers (KRT5, 15, 6A, and 16) and luminal markers (FOXA1 and KRT19). The difference in the expression level was assessed by the Mann–Whitney U test

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Molecular Cancer

ISSN: 1476-4598