Fig. 3
From: Extracellular vesicles remodel tumor environment for cancer immunotherapy
Extracellular vesicular remodelling of the lymphatic vascular microenvironment. A Impaired DC antigen presentation due to poor internalization of TEVs carrying tumor antigens. B TEV impairs and depletes TAM function. C TEV induces apoptosis of CD8T cells. D TEV activates B-cell anti-tumour IgG responses. E TEV induces lymphatic vessel endothelial cell proliferation, lymphatic vessel dilation and gap enlargement. F Metastasis of tumour cells from the dilated lymphatic vessel gap