Fig. 6

Human derived MPM organoids orthotopic xenotransplantation model (MPM-PDOX). A Body weight changes of nude mice after intraperitoneal injection three different MPM organoids. B The subarea and scoring of the Experimental Peritoneal Cancer index (ePCI) scoring system [16]. C ePCi score of three different PDOX. D - O The gross pathology of PDOX. (D, F, liver; E, diaphragm; G, pancreas, stomach; H, the images show that the tumor invaded the peritoneal peritoneum and multiple organs of nude mice; I, spleen; J, mesentery; K, retroperitoneal vascular tissue; L, kidney; M,O, peritoneum; N, pelvic cavity.) The images shown are from MPM-C6-O as a representative sample. Data were showed as mean ± SD,Each organoid line was transplanted into three mice