Fig. 7

Genetic characterization of malignant peritoneal mesothelioma (MPM) organoids. A Somatic genomic landscape of 5 MPMOs (-O) and the corresponding parental tumors (-T). The types of genetic alterations are indicated in the legend. B Somatic variation types from MPM tumors and corresponding organoids. C The top 30 genes with the highest number of variations in MPM. D Proportion of genome mutation types in MPM and corresponding organoids. E Histogram illustrating the various contributions of point mutation types in MPMOs(-O) and their respective tumors(-T), the six types of point mutation types are represented. F CNVs landscape (red, gain; blue, loss) in MPMOs (-O) and tumor tissues (-T)