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Fig. 3 | Molecular Cancer

Fig. 3

From: Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors

Fig. 3

Local consequences of IE8 disruption. a. (top) Description of differentially accessible regions in MDA-MB-231 and MDA-MB-436 upon IE8 disruption and (bottom) representation of commonly modulated regions in both cell lines. b. (top) ATAC-seq peak intensity signals of all the TSS present in the whole genome, chr11 and 10 MB around IE8 (middle) Heatmap of active TSS in TNBC models and (bottom) variations on the accessibility of promoter regions of 5’ MMPs (purple) and 3’MMPs (green) regions in MDA-MB-231 and MDA-MB-436 before and after IE8 disruption. c. Illustrative examples of variation in accessibility upon IE8 disruption (IE8dis minus WT) in the IE8 region (grey), the 5’ MMP region (purple), and the 3’MMP region(green)

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Molecular Cancer

ISSN: 1476-4598