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Fig. 5 | Molecular Cancer

Fig. 5

From: Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors

Fig. 5

Functional impact of changes in MMP protein expression and activity after IE8 disruption. Evaluation of MMP8 (a) and MMP1 (b) levels released to the extracellular space after IE8 disruption in MDA-MB-231 and MDA-MB-436. c. Time-course of MMP-1 activity in MDA-MB-231 and MDA-MB-436 upon IE8 disruption. d. (left) An illustrative example of anchorage-independent spheroid growth of MDA-MB-231 and MDA-MB-436 cell models and (right) volume quantification. e. Colorimetric quantification of cell invasion MDA-MB-231 and MDA-MB-436 cell invasion. Student’s T-test. ns: no significant, *P < 0.05, **P < 0.01, ***P < 0.001. O.D. Optical density

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Molecular Cancer

ISSN: 1476-4598