Fig. 1
From: The role of extracellular vesicles in circulating tumor cell-mediated distant metastasis
The composition of EVs and their role in tumor metastasis. The main substances of EVs are proteins, nucleic acids and lipids, which are the structural and functional basis of EVs. EVs play a role in key processes of tumor metastasis, such as promoting epithelial-mesenchymal transition (EMT), remodeling the extracellular matrix (ECM), promoting angiogenesis, activating platelets, immunosuppression, determining organotropism and promoting pre-metastatic niche (PMN) formation (Figure was created with BioRender.com).