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Fig. 1 | Molecular Cancer

Fig. 1

From: Circulating cell-free DNA methylation patterns as non-invasive biomarkers to monitor colorectal cancer treatment efficacy without referencing primary site mutation profiles

Fig. 1

Summary of Methylation Profiles in EFEMP1, SFRP2, and UNC5C of TCGA-COADREAD Data and additional 949 CRC Samples. A Methylation Profiles in EFEMP1, SFRP2, and UNC5C of TCGA-COADREAD Data. The bar graphs above compare the average β values of probes in each gene between tumors and normal mucosa. The T-bars represent the standard deviations. The central heatmaps display the β values for each probe in 395 CRC samples and 45 normal mucosa samples. The lower schematics show the positions of CpG sites in the promoter regions of each gene, the probe locations, and the PCR products (black bars of Region 1 and Region 2) analyzed by COBRA and Hi-SA. Diamonds indicate the recognition sites of the HhaI restriction enzyme, and the circled numbers indicate the probe numbers for each gene. B Associations of methylation ratio between region 1 and region 2 of EFEMP1, SFRP2, and UNC5C in stages I, II, III, and IV. The red line represents the regression line, and the light red indicates the 95% confidence interval. The Wilcoxon rank-sum test was evaluated to estimate the P values. C Frequencies of extensive, partial methylation, and unmethylation in EFEMP1, SFRP2, and UNC5C. D Frequencies of methylation score 2 or more, 1 or more according to the UICC stage

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Molecular Cancer

ISSN: 1476-4598