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Fig. 7 | Molecular Cancer

Fig. 7

From: CircPPAP2B controls metastasis of clear cell renal cell carcinoma via HNRNPC-dependent alternative splicing and targeting the miR-182-5p/CYP1B1 axis

Fig. 7

Schematic representation of the possible mechanism of circPPAP2B in ccRCC metastasis CircPPAP2B is derived from exons 3 to 5 of the PPAP2B gene through backsplicing in the nucleus. CircPPAP2B not only interacts with HNRNPC in an m6A-dependent manner to facilitate HNRNPC nuclear translocation via stabilizing HNRNPC/Vimentin/Importin α7 ternary complex, but also functions as a miRNA sponge to directly bind to miR-182-5p and modulate CYP1B1 expression, thereby promoting cancer metastasis in ccRCC

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Molecular Cancer

ISSN: 1476-4598