Fig. 2

Correlations between HSP90B1 expression and genetic alterations, immune-related genes and TME. A, B Radar charts illustrating relationship between HSP90B1 expression and MSI, TMB in pan-cancer. There are radial axes emanating from a common center, point in each axis corresponds to correlation coefficient(Spearman correlation). C-F Heat maps of association between HSP90B1 expression with the immune stimulating genes, immunosuppressive genes, chemokines and chemokine receptors. Symbols “*”, “**”, and “***” denote statistical significance with p < 0.05, p < 0.01, and p < 0.001, respectively (Pearson correlation). G, H tSEN plot revealing the landscape of distinct cell types within the single-cell transcriptomic atlas, distinct clusters and HSP90B1 expression in KIRC. J Comparison of HSP90B1 expression across diverse tumor-infiltrating lymphocyte within the TME of KIRC. K A conceptual framework outlining the role of HSP90B1 in both cancer development and therapeutic interventions