Skip to main content
Fig. 2 | Molecular Cancer

Fig. 2

From: Role of a novel circRNA-CGNL1 in regulating pancreatic cancer progression via NUDT4–HDAC4–RUNX2–GAMT-mediated apoptosis

Fig. 2

circCGNL1 represses PC cell proliferation and promotes PC cell apoptosis. A, B CCK-8 assays were performed to detect the viability of PANC-1 and BxPC-3 cells transfected with either pcDNA3.1 or pcDNA3.1-circCGNL1. C EdU-incorporation assays showing that circCGNL1 overexpression significantly reduced the proliferation of PANC-1 and BxPC-3 cells. Scale bar = 100 μm. D, E DAPI staining assay was applied to measure PC cell apoptosis (D) and the cell nuclear chromatin morphological changes was observed via TEM (E). The red arrows showed the forming of apoptotic bodies. F TUNEL assays showing that apoptosis was significantly higher in PANC-1 and BxPC-3 cells transfected with pcDNA3.1-circCGNL1 than in those transfected with empty pcDNA3.1 vector. Scale bar = 100 μm. *p < 0.05, **p < 0.01

Back to article page

Molecular Cancer

ISSN: 1476-4598