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Fig. 8 | Molecular Cancer

Fig. 8

From: Aberrant R-loop–mediated immune evasion, cellular communication, and metabolic reprogramming affect cancer progression: a single-cell analysis

Fig. 8

FANCI knockdown limited cell proliferation, colony formation, migration, invasion, and tumor-forming ability and promoted cell apoptosis. A shRNAs induced gene silencing, reducing FANCI mRNA and protein levels in A549. (B-E) FANCI knockdown clearly inhibited the proliferation (B), colony formation (C), scratch healing (D), migration, and invasion (E) abilities of PC-9 and A549. F FANCI silencing promoted apoptosis of PC-9 and A549. G FANCI silencing suppressed the tumor-forming ability of PC-9. (Student’s t-test; *p < 0.05; **p < 0.01; ***p < 0.001)

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Molecular Cancer

ISSN: 1476-4598