Fig. 2

STAT structure. The STAT protein family is composed of six distinct members: STAT1, which possesses two splicing variants (STAT1α and STAT1β), STAT2 and STAT3, which also include two splicing variants (STAT3α and STAT3β), and STAT4, STAT5a, STAT5b, and STAT6. The length of STAT proteins is approximately between 750 and 900 amino acids. Their structural components consist of the following domains: N-terminal domain, coiled-coil domain, DNA-binding domain, junction domain, SH2 domain, and transcription activation domain (TAD), starting with the N-terminus and extending to the C-terminus [9,10,11]