JAK/STAT in leukemia: a clinical update

Table 2 JAK/STAT mutations in leukemia

JAK/STAT mutations and resulting disorders
JAK/STAT	Mutation	Disease	Reference
JAK1	S703I	ALL	[59]
	T478S	AML	[60]
	V623A	AML	[60]
JAK2	JAK2/REED	AML	[61]
	V617F	AML	[62]
	K607N	AML	[63]
	T875N	AML	[64]
JAK3	A572VV722IP132T	AMKL	[62]
	M511I	PLL	[65]
	V722I	AMKL	[66]
	A572V	AMKL	[66]
	P132T	AMKL	[66]
STAT3	Y640F	LGLL	[67]
	D661Y	LGLL	[67]
	D661V	LGLL	[67]
	N647I	LGLL	[67]
		ATL	[68]
		T-LGLL	[69]
		AML	[70, 71]
STAT5		CML	[72, 73]
		AML	[74, 75]
		Ph + ALL	[76]
		B-ALL	[77]
STAT5a		TCL	[78]
STAT5b		T-PLL	[79]
	Y665F	LGLL	[80]
	N642H	LGLL、TCL	[81]
	N642H	T-ALL	[82]

ISSN: 1476-4598