Fig. 1
From: Selective autophagy in cancer: mechanisms, therapeutic implications, and future perspectives
PINK1/Parkin-induced mitophagy. As the mitochondria depolarize, PINK1 steadies and moves to the outer membrane of the mitochondria, where it attracts and phosphorylates parkin. This phosphorylation of ubiquitin molecules causes Parkin to become activated enzymatically. Numerous proteins on the outer membrane of the mitochondria are ubiquitinated by Parkin, which causes autophagy receptors to relocate to the mitochondria where they are selectively recognized by the phagocyte membrane