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Table 2 Small molecule drugs targeting autophagy have entered clinical trials

From: Selective autophagy in cancer: mechanisms, therapeutic implications, and future perspectives

Drug name

Chemical structure

Phase

Cancer

Clinical trials identifier

Ref

CQ

I

glioblastoma

NCT02378532

[193]

HCQ

II

Non-Small Cell Lung Cancer

NCT04735068

[194]

ABTL0812

I

solid tumours

NCT02201823

[195]

Sirolimus

I

Lymphangioleiomyomatosis

NCT01687179

[196]

temsirolimus

I

melanoma

NCT00281957

[197]

Pantoprazole

II

Metastatic Castration-Resistant Prostate Cancer

NCT01748500

[198]

2-OHOA

I

glioma

NCT01792310

[199]

Neratinib

I

pancreatic cancer

NCT02349867

[200]

  1. a NA Not available
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Molecular Cancer

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