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Fig. 6 | Molecular Cancer

Fig. 6

From: LINC01852 inhibits the tumorigenesis and chemoresistance in colorectal cancer by suppressing SRSF5-mediated alternative splicing of PKM

Fig. 6

LINC01852 increases the chemosensitivity of CRC cells by inhibiting aerobic glycolysis in an SRSF5/PKM2-dependent manner. (A) The relative protein expression levels of SRSF5 and PKM2 in CRC cells transfected with the indicated plasmids were detected by WB. LINC: LINC01852, Ctrl: control vector. (B, C) The proliferation (B) and colony formation (C) abilities of HCT116 and HCT8 cells were measured by CCK-8 and colony formation assays, respectively. Cells were transfected with the indicated plasmids as shown in (A). (D) Glucose uptake and lactate production were measured in HCT116 and HCT8 cells transfected with the indicated plasmids as shown in (A). (E) The sensitivities of CRC cells to 5-FU and L-OHP were assessed by a CCK-8 assay

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Molecular Cancer

ISSN: 1476-4598