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Fig. 8 | Molecular Cancer

Fig. 8

From: LINC01852 inhibits the tumorigenesis and chemoresistance in colorectal cancer by suppressing SRSF5-mediated alternative splicing of PKM

Fig. 8

SRSF5 and PKM2 expression is increased in CRC and negatively correlated with LINC01852 expression. (A) The protein levels of SRSF5 in CRC tissues (n = 139) and NCTs (n = 132) were measured via IHC. Representative images of SRSF5 IHC staining (left) and scores (right) are shown. (B) Changes in SRSF5 expression in paired samples (n = 107) are depicted in the pie chart. (C) Kaplan-Meier survival analyses based on the expression of SRSF5 in CRC tissues. (D) Violin plots were generated to visualize the distribution of LINC01852 expression in each group stratified based on the protein expression level of SRSF5/PKM2. (E) Kaplan-Meier survival curves generated based on the expression of LINC01852/SRSF5 or LINC01852/PKM2 in CRC patients. (F) Pearson correlation analyses of SRSF5 and PKM2 protein expression based on IHC staining scores. (G) Kaplan-Meier survival curves generated based on the expression of SRSF5 and PKM2 in CRC tissues. (H) Kaplan-Meier survival curves based on the expression of LINC01852, SRSF5 and PKM2 in CRC tissues. (I) A working model of the mechanism by which LINC01852 suppresses SRSF5-mediated alternative splicing of PKM to affect CRC progression

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Molecular Cancer

ISSN: 1476-4598