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Fig. 1 | Molecular Cancer

Fig. 1

From: Impact of metronomic trabectedin combined with low-dose cyclophosphamide on sarcoma microenvironment and correlation with clinical outcome: results from the TARMIC study

Fig. 1

Histogram of clinical benefit (objective response plus stable disease > 6 months) Waterfall plots of tumor response (A), Kaplan-Meier curves of progression-free (B), overall survival (C) and histological (D,E,G,H)/imaging assessment (F,I) according to immunological outcome. Only patients with accessible tumor material for immunological analysis are included (n = 28). Changes in tumor size were centrally assessed by blinded independent review according to Response Evaluation Criteria in Solid Tumors (RECIST) 1.1. Blue curve: no favorable immunological outcome, red curve: favorable immunological outcome. (D,G) Density of CD8 + T cells within the tumor on pre-treatment (D) and on-treatment (G) samples in a patient with undifferentiated pleomorphic sarcoma enrolled in the phase 2 part. (E,H) Density of CD68+(red)CD163+(green) macrophages within the tumor on pre-treatment (E) and on-treatment samples (H) in a patient with undifferentiated pleomorphic sarcoma. Long lasting partial response (F,I) in a patient with undifferentiated pleomorphic sarcoma

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Molecular Cancer

ISSN: 1476-4598