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Fig. 3 | Molecular Cancer

Fig. 3

From: Small cells – big issues: biological implications and preclinical advancements in small cell lung cancer

Fig. 3

Intratumoral heterogeneity of SCLC based on endogenous or exogeneous influences. a Intratumoral subtype switching is facilitated by enriched MYC expressions and/or increased Notch activity. This endogenous transition is assumed to proceed from NE high tumors to non-NE phenotypes. Hence, ASCL1-driven SCLCs transform into NEUROD1 and, ultimately, into YAP1-high tumors. b Exogeneous subtype transition is caused by systemic therapy, leading to selection of subclones showing intrinsic or acquired resistance. Disease recurrence accompanied by chemoresistance represents a hallmark of SCLC. Created with BioRender.com. NE - Neuroendocrine; ASCL1 - Achaete-scute homologue 1; NEUROD1 - Neurogenic differentiation factor 1; MYC - MYC proto-oncogene

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Molecular Cancer

ISSN: 1476-4598