Fig. 7

Suppression of IL-6 effectively restrains the tumor progression in vivo. A Schematic diagram illustrating that A549 cells were subcutaneously co-injected with NFs stably transfected with vector or circNOX4 into nude mice, and IL-6 antibody was locally injected twice a week. B Images of nude mice and xenograft tumors of each group (n = 8). C Tumor growth curves were shown in different treatment groups. D Tumor weights were measured in different treatment groups. E Representative images of IHC for FAP, CD31, N-cadherin, Vimentin, MMP2, and MMP9 in xenograft tumors. Scale bar = 100 μm. *P < 0.05, **P < 0.01, ***P < 0.001