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Fig. 2 | Molecular Cancer

Fig. 2

From: The m6A modification mediated-lncRNA POU6F2-AS1 reprograms fatty acid metabolism and facilitates the growth of colorectal cancer via upregulation of FASN

Fig. 2

POU6F2-AS1 promotes the growth of CRC cells and PDO in vitro. (A, D) The viability curves of CRC cells with knockdown or overexpression of POU6F2-AS1 were detected by CCK–8 assays at the indicated time points. (B, E) EdU assays were performed to assess the proliferation ability of CRC cells with POU6F2-AS1 knockdown or overexpression. (C, F) Colony formation assays were conducted to determine the proliferation of CRC cells transfected with POU6F2-AS1 knockdown or overexpression. (G, H) CRC patient-derived organoid was infected with POU6F2-AS1 overexpression or knockdown or a control lentivirus, and representative bright-field images are exhibited. The data are presented as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001

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Molecular Cancer

ISSN: 1476-4598