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Fig. 3 | Molecular Cancer

Fig. 3

From: Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p/STAT6 axis to promote gastric cancer progression

Fig. 3

Exosome circATP8A1 promotes the polarization of M0 macrophages towards M2. A IF staining was performed with PKH67 and DAPI at 2 h and 6 h following exosome treatment as indicated. B & C M1-phenotype polarization markers CD80 and CD86 were detected by qPCR. D & E M2-phenotype polarization markers CD163 and CD206 were detected by qPCR. F–H CircATP8A1, STAT6, and STAT3 were detected by qPCR. I CircATP8A1 express was positively correlative with STAT6 in our patient cohort (n = 32). P value is determined by the t-test for B-H. * P < 0.05, ** P < 0.01, *** P < 0.001. NS, not significant. OC-exo, exsomes from overexpression control cells OE-exo, exosomes from circATP8A1 overexpression cells

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Molecular Cancer

ISSN: 1476-4598