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Fig. 5 | Molecular Cancer

Fig. 5

From: Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p/STAT6 axis to promote gastric cancer progression

Fig. 5

MiR-1-3p is a target of circATP8A1 in gastric cancer. A Three miRNAs were gained by the intersection of the predicted potential targets of circATP8A1 and STAT6 in the ENCORI database. B, C, D Relative expressions of miR-206, miR-613, and miR-1-3p of macrophages after treatment with exosomes overexpressing circATP8A1. E The binding sites between circATP8A1 and miR-1-3p, miR-1-3p, and STAT6 were predicted by the ENCORI database. F CircATP8A1 was mainly localized to the cytoplasm detected by FISH. Nuclear was labeled with a DAPI stain. G Colocalization of miR-1-3p (FAM) and circATP8A1 (Cy3) detected by FISH. * P < 0.05, ** P < 0.01, *** P < 0.001. NS, not significant

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Molecular Cancer

ISSN: 1476-4598