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Fig. 7 | Molecular Cancer

Fig. 7

From: Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p/STAT6 axis to promote gastric cancer progression

Fig. 7

Co-culture of macrophages treated with extracellular vesicles and gastric cancer cells. A-C CXCL1, IL-10, and TGF-β levels in the supernatant of macrophages treated with exosomes from SGC-7901 cells overexpressing circATP8A1 were measured by ELISA. D Co-culture of macrophages treated with exosomes overexpressing circATP8A1 and SGC-7901 cells. E–F Cell migration assay of SGC-7901 after cocultured with macrophages treated with exosomes overexpressing circATP8A1. Scare bars = 100 mm. G Model of the exosome circATP8A1-mediated ontogenetic effect in gastric cancer. * P < 0.05, ** P < 0.01, *** P < 0.001. NS, not significant. OC-exo, exsomes from overexpression control cells; OE-exo, exosomes from cells overexpressing circATP8A1

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Molecular Cancer

ISSN: 1476-4598