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Fig. 8 | Molecular Cancer

Fig. 8

From: Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p/STAT6 axis to promote gastric cancer progression

Fig. 8

Role of circATP8A1 and related exosomes in gastric cancer confirmed by in vivo experiments. A Schematic diagram of cell transplantation of control group and circATP8A1 knockdown group. B Gross image indicates subcutaneous xenograft tumor model (n = 6). C Tumor growth curves of indicated groups were measured every 3 days for a total of 31 days. D Tumor weights were measured on day 31. E H&E staining and IHC staining of Ki-67 of circATP8A1 know-down group and control group. F Schematic diagram of cell transplantation and exosome injection. G Gross images of tissue specimens from the subcutaneous xenograft tumor model in nude mice. H-I Tumor growth rate and tumor weight of the subcutaneous xenograft tumor model in nude mice. J H&E staining and IHC staining of Ki-67 of indicate groups. * P < 0.05, ** P < 0.01, *** P < 0.001. NS, not significant. shNC, the knockdown-control group; sh1-circATP8A, circATP8A1 knockdown group1. OC-exo, exsomes from overexpression control cells; OE-exo, exosomes from cells overexpressing circATP8A1

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Molecular Cancer

ISSN: 1476-4598