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Fig. 2 | Molecular Cancer

Fig. 2

From: Bladder-cancer-derived exosomal circRNA_0013936 promotes suppressive immunity by up-regulating fatty acid transporter protein 2 and down-regulating receptor-interacting protein kinase 3 in PMN-MDSCs

Fig. 2

BCa-derived exosomes up-regulated FATP2 and down-regulated RIPK3 in PMN-MDSCs. (A) Morphological characteristics of BCa-derived exosomes revealed by transmission electron microscopy (bar = 100 nm). (B) Immunofluorescence showed that the BCa-derived exosomes (green) were gradually taken up by PMN-MDSCs. (C and D) Detection of the expression of RIPK3 and FATP2 in PMN-MDSCs using Western blotting. (E) Detection of Prostaglandin E2 (PGE2), Arachidonic Acid (AA), and Triglycerides (TG) in PMN-MDSCs by LC/MS. (F) ELISA detected the levels of immunosuppressive molecules (IL-10, INOS, Arg-1) in PMN-MDSCs. (*P < 0.05)

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Molecular Cancer

ISSN: 1476-4598