Experimental model of senescence | Cell type | SASP regulators | Pharmacological inhibition | Genetic inhibition | Reference |
---|---|---|---|---|---|
H-RAS V12 | Human fibrobasts (IMR90) | HMGB2 | Nd | shRNA | [184] |
4-OHT/H-RASV12 | Human fibrobasts (IMR90) | MLL1 | M-2-2 | shRNA | [185] |
H-RAS V12 | Human fibrobasts (IMR90; WI-38) | BRD4 | JQ1 | shRNA | [42] |
Pten−/− mice | Prostate tumors | JAK2/STAT3 | NVP-BSK805 | Stat3−/− mice | [187] |
Ionizing radiation | Pre-adipocytes; HUVEC | JAK1/2 | Ruxolitinib | nd | [188] |
Ionizing radiation | Human fibrobasts (IMR90 and WI-38) | G3BP1 | EGCG* | shRNA | [168] |
4-OHT/ ER:RAS | Human fibrobasts (IMR90; BJ;HFFF2) | mTORC1 | Rapamycin Torin1 NVP-BEZ235 | shRNA | [190] |
4-OHTor Etoposide/ H-RASV12; pancreatic cancer mouse model | Human fibrobasts (IMR90) | IL1R/IL-1α | Nd | shRNA; IL1R−/− mice | [192] |
4-OHT/ ER:RAS | Human fibrobasts (IMR90);MR90;MCF7 | PTBP1 | Nd | siRNA | [186] |