Fig. 4
From: Crosstalk between metabolism and cell death in tumorigenesis
Metabolites, metabolic pathways and related metabolic genes that play the roles in pyroptosis. NLRP3 plays an important role in the process of pyroptosis, which inhibition of NLRP3 will lead to the downregulation of pyroptosis. LDLR inhibits pyroptosis by mediating NLRP3. DHA promotes pyroptosis through affecting caspase1, and FABP4 exert the same effect through activating GSDMD. GPX4 inhibit pyroptosis by affecting the processing of GSDMD by caspase11, respectively. The red boxes represent negative regulators and the green boxes represent positive regulators