Table 1 Selected drugs or molecules associated with apoptosis in oncology research, their effects on apoptosis and targets of action
From: Crosstalk between metabolism and cell death in tumorigenesis
Cell death | Medicine | Inhibition or promotion | Target | References |
|---|---|---|---|---|
Apoptosis | Smac/Diablo | Promotion | IAP | |
Apoptosis | Sulforaphane | Promotion | Bax/Bak | [271] |
Apoptosis | Cisatracurium | Promotion | lncRNA-p21 | [272] |
Apoptosis | Obatoclax | Promotion | Bcl-2, Survivin, Wnt/β-catenin pathway | |
Apoptosis | NO.0449 − 0145 | Promotion | APE1 | [275] |
Apoptosis | Curcumin | Promotion | Caspase8/9/3 | |
Apoptosis | Diosmetin | Promotion | STAT3/c-Myc pathway | [278] |
Apoptosis | z-VDVAD-fmk, z-IETD-fmk | Inhibition | Caspase2/8 | [279] |
Apoptosis | Tauroursodeoxycholic acid | Inhibition | ER stress | [280] |