Table 4 Selected drugs or molecules associated with ferroptosis in oncology research, their effects on ferroptosis and targets of action
From: Crosstalk between metabolism and cell death in tumorigenesis
Cell death | Medicine | Inhibition or promotion | Target | References | |
|---|---|---|---|---|---|
Ferroptosis | Erastin | Promotion | System Xc- | [98] | Â |
Ferroptosis | Brequinar | Promotion | DHODH | [289] | Â |
Ferroptosis | Nortriptyline hydrochloride | Promotion | RBMS1 | [290] | Â |
Ferroptosis | Erianin | Promotion | Ca2+/CaM | [291] | Â |
Ferroptosis | RSL3 | Promotion | GPX4, NF-κB |  | |
Ferroptosis | Tagitinin C | Promotion | PERK-Nrf2-HO-1 | [294] | Â |
Ferroptosis | Metformin | Promotion | SLC7A11 | [295] | Â |
Ferroptosis | Dihydroartemisinin | Promotion | AMPK/mTOR/p70S6k | [296] | Â |
Ferroptosis | Elesclomol, copper | Promotion | ATP7A | [297] | Â |
Ferroptosis | Cetuximab | Promotion | NRF2/HO-1 | [298] | Â |
Ferroptosis | EF24 | Promotion | HMOX1 | [299] | Â |
Ferroptosis | Flubendazole | Promotion | P53 | [300] | Â |
Ferroptosis | Simvastatin | Promotion | HMGCR | [301] | Â |
Ferroptosis | Apatinib | Promotion | SREBP-1α, GSH | [302] |  |
Ferroptosis | Ferrostatin-1, Liproxstatin‑1 | Inhibition | lipid peroxidation |  | |
Ferroptosis | Dihydroartemisinin | Inhibition | PERK/ATF4/HSPA5 | [304] | Â |