Crosstalk between metabolism and cell death in tumorigenesis

Table 5 Selected drugs or molecules associated with pyroptosis in oncology research, their effects on pyroptosis and targets of action

Cell death	Medicine	Inhibition or promotion	Target	References
Pyroptosis	NO.0449 − 0145	Promotion	APE1A	[275]
Pyroptosis	Metformin	Promotion	AMPK/SIRT1/NF-κB	[305]
Pyroptosis	Paclitaxel, Cisplatin, Miltirone, Tetraarsenic hexoxide	Promotion	GSDME	[306,307,308]
Pyroptosis	α-KG	Promotion	DR6	[137]
Pyroptosis	Val-boroPro	Promotion	CARD8	[309]
Pyroptosis	Benzimidazoles	Promotion	NF-κB/NLRP3/GSDMD	[310]
Pyroptosis	Dihydroartemisinin	Promotion	AIM2/Caspase-3/ DFNA5	[311]
Pyroptosis	Metformin	Promotion	FOXO3	[312]
Pyroptosis	Disulfiram, Cucurbitacin B	Inhibition	GSDMD	[313, 314]

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