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Fig. 10 | Molecular Cancer

Fig. 10

From: Exosomal long non-coding RNA TRPM2-AS promotes angiogenesis in gallbladder cancer through interacting with PABPC1 to activate NOTCH1 signaling pathway

Fig. 10

Schematic of the role of the IGF2BP2-TRPM2-AS/PABPC1-NUMB-NOTCH1 axis in GBC angiogenesis. In GBC cells, IGF2BP2 increases the stability of TRPM2-AS in an m6A-dependent manner, and overexpressed TRPM2-AS in tumors can be transferred to endothelial cells via exosomes and promote endothelial cells angiogenesis by activating the NOTCH1 signaling pathway. Mechanistically, TRPM2-AS promotes the degradation of NUMB mRNA by enhancing the interaction of PABPC1 with NUMB mRNA. Further studies have shown that PABPC1 interacts with AGO2 and then inhibits the expression of NUMB by promoting miR-31-5p and miR-146a-5p-mediated NUMB degradation

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Molecular Cancer

ISSN: 1476-4598