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Fig. 1 | Molecular Cancer

Fig. 1

From: Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-κB p65 nuclear translocation

Fig. 1

Therapy-induced cancer cell senescence was observed in human LARC tissues of cohort 1. (A) IHC staining of p16 and p21 in 22 matched LARC tissues. pre-NAT, colonoscopic biopsy specimens before NAT. post-NAT, surgical specimens after NAT. (B) The staining distribution of p16 and p21. (C) The intensity score of p16 and p21. (D and E) The IRS of p16 and p21. (F) Kaplan-Meier plots of DFS. The plot was generated according to the difference between pre-NAT IRS and post-NAT IRS of p16 (p16-diff) and p21 (p21-diff). *p < 0.05, **p < 0.01, and ***p < 0.001

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Molecular Cancer

ISSN: 1476-4598