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Fig. 5 | Molecular Cancer

Fig. 5

From: Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-κB p65 nuclear translocation

Fig. 5

EVs secreted from STCs further enhanced the malignant biological behaviors of recipient cancer cells. (A) CRC cells were incubated with or without EVs (15 µg/ml) and then analyzed for cell viability via CCK-8 assay. (B-E) CRC cells were cultured with or without EVs (15 µg/ml) for 48 h. Ctrl-EVs, EVs derived from untreated CRC cells. Sen-EVs, EVs from senescent CRC cells. (B) Cell migration and invasion abilities were analyzed by transwell assay. (C) Quantification of migratory cells, invasive cells, and wound-healing rates. (D) Representative wound-healing images of CRC cells. (E) E-cadherin, Snail, Slug, and MMP9 protein levels. Data represented the mean ± standard deviation of at least 3 independent experiments. *p < 0.05, **p < 0.01, and ***p < 0.001

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Molecular Cancer

ISSN: 1476-4598