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Fig. 7 | Molecular Cancer

Fig. 7

From: Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-κB p65 nuclear translocation

Fig. 7

SERPINE1 was responsible for the tumor-promoting effect of EVs secreted from STCs. (A) Cell viability of CRC cells cultured with EVs at the indicated time points. (B) Schematic illustration of the establishment of the in vivo tumor model. (C) The tumor growth curve. (D) Images of the excised xenograft tumors. (E) Measurement of tumor weight. (F) H&E and IHC staining of Ki-67. (G-I) CRC cells were cultured with EVs (15 µg/ml) for 48 h. (G) The migration and invasion abilities of recipient CRC cells were analyzed by transwell assay. (H) Quantification of migratory cells, invasive cells, and wound-healing rates. (I) SERPINE1, E-cadherin, Snail, Slug, and MMP9 protein levels. Data represented the mean ± standard deviation of at least 3 independent experiments. *p < 0.05, **p < 0.01, and ***p < 0.001

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Molecular Cancer

ISSN: 1476-4598