Fig. 2
From: Loss of lncRNA LINC01056 leads to sorafenib resistance in HCC
Linc01056 was required for sorafenib response in HCC. (a) Knockdown of Linc01056 in MHCC97L and PLC/PRF/5 cells by shRNA interference. (b) Knockdown of Linc01056 increased cell viability in sorafenib-treated HCC cells. (c) Rescue of Linc01056 potentiated the resistant HCC cells to sorafenib treatment. (d) Knockdown of Linc01056 improved colonic formation of HCC cells in the presence of sorafenib. (e) Knockdown of Linc01056 reduced sorafenib-induced apoptosis in HCC cells. Stable knockdown of Linc01056 (f) accelerated in vivo tumour growth and (g) end-point tumour size, (h) reduced expression of cell apoptosis marker cleaved caspase-3 and (i) promoted the cell proliferation marker Ki67. *pā<ā0.05, **pā<ā0.01, ***pā<ā0.001