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Fig. 4 | Molecular Cancer

Fig. 4

From: Drug resistance mechanisms and treatment strategies mediated by Ubiquitin-Specific Proteases (USPs) in cancers: new directions and therapeutic options

Fig. 4

USPs regulate molecular targeted drug resistance. A USPs deubiquitinate key nuclear proteins, enhancing DNA damage repair and leading to resistance to PARP inhibitors. Inhibitors targeting USP7 improve the therapeutic efficacy of PARP inhibitors in treating cancer. B USPs are involved in imatinib (IM) resistance in chronic myeloid leukemia (CML) and gastrointestinal stromal tumors

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Molecular Cancer

ISSN: 1476-4598