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Table 2 Genes changed basally with RIP140 siRNA

From: Selective repression of retinoic acid target genes by RIP140 during induced tumor cell differentiation of pluripotent human embryonal carcinoma cells

Gene symbol

Gene description

Fold change RIP140 siRNA/ctrl siRNA

p-value

FOLR1

Folate receptor 1 (adult)

-4.65

0.000730

RAB3B

RAB3B, member RAS oncogene family

-4.33

0.005952

SMAD5

SMAD family member 5

-3.28

0.003862

MALAT1

Metastasis associated lung adenocarcinoma 1 (non-coding RNA)

-3.20

0.000468

DCX

Doublecortex; lissencephaly, X-linked (doublecortin)

+2.82

0.000682

B3GAT3

Beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)

-2.63

0.005142

C14orf111

Chromosome 14 open reading frame 111

-2.62

0.003088

SMAD5

SMAD family member 5

-2.60

0.006314

CUTL1

Cut-like 1, CCAAT displacement protein (Drosophila)

-2.52

0.001457

C18orf54

Chromosome 18 open reading frame 54

-2.51

0.003054

PTBP2

Polypyrimidine tract binding protein 2

-2.48

0.004811

NRIP1

Nuclear receptor interacting protein 1

-2.42

0.011665

RSN

Restin (Reed-Steinberg expressed intermediate filament-associated)

-2.36

0.007189

UHMK1

U2AF homology motif (UHM) kinase 1

-2.34

0.009057

FNIP1

Folliculin interacting protein 1

-2.34

0.003628

PCBP2

Poly(rC) binding protein 2

-2.28

0.001479

BAT2D1

BAT2 domain containing 1

-2.28

0.001042

FAM80B

Family with sequence similarity 80, member B

-2.26

0.008836

UHMK1

U2AF homology motif (UHM) kinase 1

-2.26

0.002063

XKR6

XK, Kell blood group complex subunit-related family, member 6

-2.23

0.001595

BACH1

BTB and CNC homology 1, basic leucine zip transcription factor 1

-2.22

0.006338

LOC158863

Hypothetical protein LOC158863

-2.22

0.001177

GPD2

Glycerol-3-phosphate dehydrogenase 2 (mitochondrial)

-2.22

0.004723

LOC552889

Hypothetical LOC552889

-2.18

0.014483

RBAK

RB-associated KRAB zinc finger

-2.17

0.001749

ZFR

Zinc finger RNA binding protein

-2.14

0.001579

SLC39A14

Solute carrier family 39 (zinc transporter), member 14

-2.14

0.000483

UHMK1

U2AF homology motif (UHM) kinase 1

-2.12

0.000315

HNRPU

Heterogen nuclear ribonucleoprotein U (scaffold attach factor A)

-2.12

0.000802

PGGT1B

Protein geranylgeranyltransferase type I, beta subunit

-2.10

0.002873

ZNF660

Zinc finger protein 660

-2.09

0.001916

ZNF655

Zinc finger protein 655

-2.09

0.011026

CDC42

Cell division cycle 42 (GTP binding protein, 25 kDa)

-2.08

0.001266

ESCO1

Establishment of cohesion 1 homolog 1 (S. cerevisiae)

-2.08

0.002092

UBE2W

Ubiquitin-conjugating enzyme E2W (putative)

-2.07

0.010394

HECTD1

HECT domain containing 1

-2.06

0.012537

UFM1

Ubiquitin-fold modifier 1

-2.05

0.003571

LOC641298

PI-3-kinase-related kinase SMG-1 – like locus

+2.03

0.000555

GCNT2

Glucosaminyl (N-acetyl) transferase 2, (I blood group)

-2.03

0.001021

EDG7

Endothelial differentiation, lysophosphatidic acid G-coupled recept

-2.03

0.013785

  1. Gene list represents genes in scatter plot of Figure 3E; Group 3 (siRNA RIP140 vehicle) vs. Group 1 (control siRNA vehicle). Genes with p-value < 0.05 are ranked by fold-change. In bold is DCX the one gene changed basally in siRNA RIP140 cells that is not also changed by RA in control siRNA cells. Also in bold is RIP140 (NRIP1). For genes with multiple probe sets, the probe set with the greatest differential expression was chosen.