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Figure 4 | Molecular Cancer

Figure 4

From: BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study

Figure 4

BRAFV600E enhances the migrating and invasive capacity of colon adenocarcinoma cells through RhoA activation. (A) GST-pull down assay for RhoA activation and quantification (upper and middle panel) and western blot analysis of pSer445BRAF levels in a panel of cell lines (lower panel). (B) Western blot analysis p-Cofilin that is enhanced in Caco-BR13 and Caco-BR23 cells as compared to the parental Caco-2 cells (upper panel) and quantification (lower panel).

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