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  1. Content type: Research

    Increasing evidence has revealed a close relationship between non-coding RNAs and cancer progression. Circular RNAs (circRNAs), a recently identified new member of non-coding RNAs, are demonstrated to particip...

    Authors: Liyan Wang, Haiyan Long, Qinghua Zheng, Xiaotong Bo, Xuhua Xiao and Bin Li

    Citation: Molecular Cancer 2019 18:119

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  2. Content type: Retraction Note

    The Editor-in-Chief has retracted this article [1] because Figure 6b overlaps with Figure 8 of [2] and Figure 4a overlaps with Figure 2b of [3]

    Authors: Wenqiao Zang, Yuanyuan Wang, Tao Wang, Yuwen Du, Xiaonan Chen, Min Li and Guoqiang Zhao

    Citation: Molecular Cancer 2019 18:118

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    The original article was published in Molecular Cancer 2015 14:37

  3. Content type: Correction

    After the publication of this work [1], a spelling error was found: the ID of the circRNA, termed circYAP1, in the original publication was misspelled as “has_circ_0002320”.

    Authors: Hui Liu, Yuan Liu, Zhaolian Bian, Jing Zhang, Rui Zhang, Xiaoyu Chen, Yanxia Huang, Yang Wang and Jinshui Zhu

    Citation: Molecular Cancer 2019 18:117

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    The original article was published in Molecular Cancer 2018 17:151

  4. Content type: Review

    Exosomes have emerged as critical mediators of intercellular communication, both locally and systemically, by regulating a diverse range of biological processes between cells. Circular RNA (circRNA) is a novel...

    Authors: Yangxia Wang, Jinbo Liu, Junfen Ma, Ting Sun, Quanbo Zhou, Weiwei Wang, Guixian Wang, Pingjun Wu, Haijiang Wang, Li Jiang, Weitang Yuan, Zhenqiang Sun and Liang Ming

    Citation: Molecular Cancer 2019 18:116

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  5. Content type: Research

    UCA1 is a long non-coding RNA which was found overexpressed in various human cancers including gastric cancer (GC). It is identified that UCA1 promotes GC cells proliferation, migration and invasion, however, ...

    Authors: Chao-Jie Wang, Chun-Chao Zhu, Jia Xu, Ming Wang, Wen-Yi Zhao, Qiang Liu, Gang Zhao and Zi-Zhen Zhang

    Citation: Molecular Cancer 2019 18:115

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  6. Content type: Research

    Virtually all patients with metastatic prostate cancer (PCa) will relapse and develop lethal castration-resistant prostate cancer (CRPC). Long noncoding RNAs (lncRNAs) are emerging as critical regulatory eleme...

    Authors: Huy Q. Ta, Hilary Whitworth, Yi Yin, Mark Conaway, Henry F. Frierson Jr, Moray J. Campbell, Ganesh V. Raj and Daniel Gioeli

    Citation: Molecular Cancer 2019 18:113

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  7. Content type: Research

    Colorectal carcinoma (CRC) is one of the most common malignant tumors, and its main cause of death is tumor metastasis. RNA N6-methyladenosine (m6A) is an emerging regulatory mechanism for gene expression and met...

    Authors: Ting Li, Pei-Shan Hu, Zhixiang Zuo, Jin-Fei Lin, Xingyang Li, Qi-Nian Wu, Zhan-Hong Chen, Zhao-Lei Zeng, Feng Wang, Jian Zheng, Demeng Chen, Bo Li, Tie-Bang Kang, Dan Xie, Dongxin Lin, Huai-Qiang Ju…

    Citation: Molecular Cancer 2019 18:112

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  8. Content type: Research

    Circular RNAs (circRNAs) are a novel class of endogenous noncoding RNAs formed by a covalently closed loop, and increasing evidence has revealed that circRNAs play crucial functions in regulating gene expressi...

    Authors: Qun Lu, Tianyao Liu, Huijin Feng, Rong Yang, Xiaozhi Zhao, Wei Chen, Bo Jiang, Haixiang Qin, Xu Guo, Minghui Liu, Limin Li and Hongqian Guo

    Citation: Molecular Cancer 2019 18:111

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  9. Content type: Research

    METTL3 is known to be involved in all stages in the life cycle of RNA. It affects the tumor formation by the regulation the m6A modification in the mRNAs of critical oncogenes or tumor suppressors. In bladder ...

    Authors: Jie Han, Jing-zi Wang, Xiao Yang, Hao Yu, Rui Zhou, Hong-Cheng Lu, Wen-Bo Yuan, Jian-chen Lu, Zi-jian Zhou, Qiang Lu, Ji-Fu Wei and Haiwei Yang

    Citation: Molecular Cancer 2019 18:110

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  10. Content type: Research

    Progression to a castration resistance state is the main cause of deaths in prostate cancer (PCa) patients. Androgen Receptor (AR) signaling plays the central role in progression of Castration Resistant Prosta...

    Authors: Peng Gu, Xu Chen, Ruihui Xie, Weibin Xie, Li Huang, Wen Dong, Jinli Han, Xiaodong Liu, Jihong Shen, Jian Huang and Tianxin Lin

    Citation: Molecular Cancer 2019 18:109

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  11. Content type: Research

    Changes in glycogen metabolism is an essential feature among the various metabolic adaptations used by cancer cells to adjust to the conditions imposed by the tumor microenvironment. Our previous study showed ...

    Authors: Lifeng Li, Li Yang, Shiqi Cheng, Zhirui Fan, Zhibo Shen, Wenhua Xue, Yujia Zheng, Feng Li, Dong Wang, Kai Zhang, Jingyao Lian, Dan Wang, Zijia Zhu, Jie Zhao and Yi Zhang

    Citation: Molecular Cancer 2019 18:108

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  12. Content type: Correction

    Following publication of the original article [1], the authors reported that name that appeared in published online version is incorrect. Aifeng Wang should be Aifen Wang. Corrected name is provided in the aut...

    Authors: Yu Yin, Lingfan Xu, Yan Chang, Tao Zeng, Xufeng Chen, Aifen Wang, Jeff Groth, Wen-Chi Foo, Chaozhao Liang, Hailiang Hu and Jiaoti Huang

    Citation: Molecular Cancer 2019 18:107

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    The original article was published in Molecular Cancer 2019 18:11

  13. Content type: Research

    Cancer cells become immortalized through telomere maintenance mechanisms, such as telomerase reverse transcriptase (TERT) activation. In addition to maintaining telomere length, TERT activates manifold cell su...

    Authors: Zhenhua Luo, Weixu Wang, Feng Li, Zhou Songyang, Xuyang Feng, Changchang Xin, Zhiming Dai and Yuanyan Xiong

    Citation: Molecular Cancer 2019 18:106

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  14. Content type: Research

    Recently, the dysregulation of circular RNA (circRNA) have been shown to have important regulatory roles in cancer development and progression, including hepatocellular carcinoma (HCC). However, the roles of m...

    Authors: Peng-Fei Zhang, Chuan-Yuan Wei, Xiao-Yong Huang, Rui Peng, Xuan Yang, Jia-Cheng Lu, Chi Zhang, Chao Gao, Jia-Bin Cai, Ping-Ting Gao, Dong-Mei Gao, Guo-Ming Shi, Ai-Wu Ke and Jia Fan

    Citation: Molecular Cancer 2019 18:105

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  15. Content type: Retraction Note

    The authors have retracted this article [1] because there are errors in Figures 4a and 4b

    Authors: Ze-you Wang, Min Hu, Min-hui Dai, Jing Xiong, Shuai Zhang, Han-jiang Wu, Shan-shan Zhang and Zhao-jian Gong

    Citation: Molecular Cancer 2019 18:104

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    The original article was published in Molecular Cancer 2018 17:3

  16. Content type: Review

    N6-methyladenosine (m6A) is identified as the most common, abundant and conserved internal transcriptional modification, especially within eukaryotic messenger RNAs (mRNAs). M6A modification is installed by the m

    Authors: Xiao-Yu Chen, Jing Zhang and Jin-Shui Zhu

    Citation: Molecular Cancer 2019 18:103

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  17. Content type: Review

    There is growing evidence that regions of the genome that cannot encode proteins play an important role in diseases. These regions are usually transcribed into long non-coding RNAs (lncRNAs). LncRNAs, little o...

    Authors: Lei Zhang, Xiang Meng, Xin-wei Zhu, Deng-cheng Yang, Ran Chen, Yong Jiang and Tao Xu

    Citation: Molecular Cancer 2019 18:102

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  18. Content type: Review

    Autophagy is a highly conserved catabolic process that mediates degradation of pernicious or dysfunctional cellular components, such as invasive pathogens, senescent proteins, and organelles. It can promote or...

    Authors: Hong-Tao Chen, Hao Liu, Min-Jie Mao, Yuan Tan, Xiang-Qiong Mo, Xiao-Jun Meng, Meng-Ting Cao, Chu-Yu Zhong, Yan Liu, Hong Shan and Guan-Min Jiang

    Citation: Molecular Cancer 2019 18:101

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  19. Content type: Review

    Apoptosis resistance is to a large extent a major obstacle leading to chemotherapy failure during cancer treatment. Bypassing the apoptotic pathway to induce cancer cell death is considered to be a promising a...

    Authors: Yitao Gong, Zhiyao Fan, Guopei Luo, Chao Yang, Qiuyi Huang, Kun Fan, He Cheng, Kaizhou Jin, Quanxing Ni, Xianjun Yu and Chen Liu

    Citation: Molecular Cancer 2019 18:100

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  20. Content type: Research

    Our previous report demonstrated that genetic ablation of miR-301a reduces Kras-driven lung tumorigenesis in mice. However, the impact of miR-301a on host anti-tumor immunity remains unexplored. Here we assessed ...

    Authors: Xun Li, Mingtian Zhong, Jiexuan Wang, Lei Wang, Zhanwen Lin, Zhi Cao, Zhujuan Huang, Fengxue Zhang, Yong Li, Ming Liu and Xiaodong Ma

    Citation: Molecular Cancer 2019 18:99

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  21. Content type: Letter to the Editor

    Cancer-associated chromosomal translocations are reported to generate oncogenic circular RNA (circRNA), contributing to tumorigenesis. The fusion gene SLC34A2-ROS1 (solute carrier family 34 member 2 and ROS proto...

    Authors: Ke Wu, Xun Liao, Youling Gong, Juan He, Jian-Kang Zhou, Shuangyan Tan, Wenchen Pu, Canhua Huang, Yu-Quan Wei and Yong Peng

    Citation: Molecular Cancer 2019 18:98

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  22. Content type: Review

    Microbiota is just beginning to be recognized as an important player in carcinogenesis and the interplay among microbes is greater than expected. Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal dise...

    Authors: Miao-Yan Wei, Si Shi, Chen Liang, Qing-Cai Meng, Jie Hua, Yi-Yin Zhang, Jiang Liu, Bo Zhang, Jin Xu and Xian-Jun Yu

    Citation: Molecular Cancer 2019 18:97

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  23. Content type: Research

    The TG-interacting factor 1 (TGIF1) gene, which encodes a nuclear transcriptional corepressor of the TGFβ1/Smad signaling pathway, has been implicated in the pathogenesis of various types of human cancer; howe...

    Authors: Ching-Chieh Weng, Mei-Jen Hsieh, Chia-Chen Wu, Yu-Chun Lin, Yan-Shen Shan, Wen-Chun Hung, Li-Tzong Chen and Kuang-Hung Cheng

    Citation: Molecular Cancer 2019 18:96

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  24. Content type: Research

    Circular RNAs (circRNAs) have been considered to mediate occurrence and development of human cancers, generally acting as microRNA (miRNA) sponges to regulate downstream genes expression. However, the aberrant...

    Authors: Wei Dong, Junming Bi, Hongwei Liu, Dong Yan, Qingqing He, Qianghua Zhou, Qiong Wang, Ruihui Xie, Yinjie Su, Meihua Yang, Tianxin Lin and Jian Huang

    Citation: Molecular Cancer 2019 18:95

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  25. Content type: Research

    Mediator complex subunit 12 (MED12) is an essential hub for transcriptional regulation, in which mutations and overexpression were reported to be associated with several kinds of malignancies. Nevertheless, th...

    Authors: Meng Xu, Fang Wang, Guibo Li, Xiaokun Wang, Xiaona Fang, Haoxuan Jin, Zhen Chen, Jianye Zhang and Liwu Fu

    Citation: Molecular Cancer 2019 18:93

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  26. Content type: Letter to the Editor

    The receptor for hyaluronic acid-mediated motility (RHAMM) is upregulated in various cancers. We previously screened genes upregulated in human hepatocellular carcinomas for their metastatic function in a mous...

    Authors: Soyoung Choi, Dunrui Wang, Xiang Chen, Laura H. Tang, Akanksha Verma, Zhengming Chen, Bu Jung Kim, Leigh Selesner, Kenneth Robzyk, George Zhang, Sharon Pang, Teng Han, Chang S. Chan, Thomas J. Fahey III, Olivier Elemento and Yi-Chieh Nancy Du

    Citation: Molecular Cancer 2019 18:92

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  27. Content type: Research

    Cancer associated fibroblasts (CAFs) are key stroma cells that play dominant roles in tumor progression. However, the CAFs-derived molecular determinants that regulate colorectal cancer (CRC) metastasis and ch...

    Authors: J. L. Hu, W. Wang, X. L. Lan, Z. C. Zeng, Y. S. Liang, Y. R. Yan, F. Y. Song, F. F. Wang, X. H. Zhu, W. J. Liao, W. T. Liao, Y. Q. Ding and L. Liang

    Citation: Molecular Cancer 2019 18:91

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  28. Content type: Review

    Circular RNAs (circRNAs) are a class of RNA molecules with closed loops and high stability. CircRNAs are abundantly expressed in eukaryotic organisms and exhibit both location- and step-specificity. In recent ...

    Authors: Min Su, Yuhang Xiao, Junliang Ma, Yanyan Tang, Bo Tian, Yuqin Zhang, Xu Li, Zhining Wu, Desong Yang, Yong Zhou, Hui Wang, Qianjin Liao and Wenxiang Wang

    Citation: Molecular Cancer 2019 18:90

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  29. Content type: Research

    The biology function of antisense intronic long noncoding RNA (Ai-lncRNA) is still unknown. Meanwhile, cancer patients with paclitaxel resistance have limited therapeutic options in the clinic. However, the po...

    Authors: Shouping Xu, Peiyuan Wang, Jian Zhang, Hao Wu, Shiyao Sui, Jinfeng Zhang, Qin Wang, Kun Qiao, Weiwei Yang, Hongbiao Xu and Da Pang

    Citation: Molecular Cancer 2019 18:89

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  30. Content type: Research

    Myeloid-derived suppressor cells (MDSCs) and cancer stem cells (CSCs) are two important cellular components in the tumor microenvironment, which may modify the cancer phenotype and affect patient survival. How...

    Authors: Lisha Ai, Shidai Mu, Chunyan Sun, Fengjuan Fan, Han Yan, You Qin, Guohui Cui, Yadan Wang, Tao Guo, Heng Mei, Huafang Wang and Yu Hu

    Citation: Molecular Cancer 2019 18:88

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  31. Content type: Research

    Long noncoding RNAs (lncRNAs) have emerged as critical players in cancer progression, but their functions in colorectal cancer (CRC) metastasis have not been systematically clarified.

    Authors: Yingmin Wu, Xiangling Yang, Zhuojia Chen, Lin Tian, Guanmin Jiang, Feng Chen, Jiexin Li, Panpan An, Linlin Lu, Nan Luo, Jun Du, Hong Shan, Huanliang Liu and Hongsheng Wang

    Citation: Molecular Cancer 2019 18:87

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  32. Content type: Research

    Clear cell renal cell carcinoma (CCRCC) is characterized by a highly metastatic potential. The stromal communication between stem cells and cancer cells critically influences metastatic dissemination of cancer...

    Authors: Lu Wang, Guang Yang, Danfeng Zhao, Jiaqi Wang, Yang Bai, Qiang Peng, Hongzhi Wang, Ruizhe Fang, Guang Chen, Zhichao Wang, Keliang Wang, Guangbin Li, Yinhui Yang, Ziqi Wang, Pengyu Guo, Li Peng…

    Citation: Molecular Cancer 2019 18:86

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  33. Content type: Research

    Lung cancer patients with KRAS mutation(s) have a poor prognosis due in part to the development of resistance to currently available therapeutic interventions. Development of a new class of anticancer agents t...

    Authors: Ke Xu, Dongkyoo Park, Andrew T. Magis, Jun Zhang, Wei Zhou, Gabriel L. Sica, Suresh S. Ramalingam, Walter J. Curran and Xingming Deng

    Citation: Molecular Cancer 2019 18:85

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  34. Content type: Research

    Long noncoding RNAs (lncRNAs), defined as the transcripts longer than 200 nt without protein-coding capacity, have been found to be aberrantly expressed in diverse human diseases including cancer. A reciprocal...

    Authors: Xuefei Wang, Jianling Yang, Guijie Guo, Riyue Feng, Ke Chen, Yuan Liao, Lianfeng Zhang, Liping Sun, Shile Huang and Ji-Long Chen

    Citation: Molecular Cancer 2019 18:84

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  35. Content type: Review

    The proliferation and metastasis ability of tumors are mediate by the "mutual dialogue" between cells in the tumor microenvironment (TME). Extracellular vesicles (EVs), mainly exosomes and microvesicles, play ...

    Authors: Changqing Xie, Ning Ji, Zhangui Tang, Jing Li and Qianming Chen

    Citation: Molecular Cancer 2019 18:83

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  36. Content type: Research

    Gallbladder cancer is the most common biliary tract malignancy and not sensitive to chemotherapy. Autophagy is an important factor prolonging the survival of cancer cells under chemotherapeutic stress. We aime...

    Authors: Qiang Cai, Shouhua Wang, Longyang Jin, Mingzhe Weng, Di Zhou, Jiandong Wang, Zhaohui Tang and Zhiwei Quan

    Citation: Molecular Cancer 2019 18:82

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  37. Content type: Research

    The aberrant expression of long noncoding RNAs (lncRNAs) has recently emerged as key molecules in human cancers; however, whether lncRNAs are implicated in the progression of clear cell renal cell carcinoma (c...

    Authors: Wei Zhai, Rujian Zhu, Junjie Ma, Dongkui Gong, Haimin Zhang, Jin Zhang, Yonghui Chen, Yiran Huang, Junhua Zheng and Wei Xue

    Citation: Molecular Cancer 2019 18:81

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  38. Content type: Research

    Accumulating evidence shows that, the dysregulation of circular RNAs (circRNAs) is associated with the progression of multiple malignancies. But, the underlying mechanisms by which has_circ_0032627 (circDLST) ...

    Authors: Jing Zhang, Lidan Hou, Rui Liang, Xiaoyu Chen, Rui Zhang, Wei Chen and Jinshui Zhu

    Citation: Molecular Cancer 2019 18:80

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  39. Content type: Research

    Emerging evidence indicates that tumor cells release a large amount of exosomes loaded with cargos during tumorigenesis. Exosome secretion is a multi-step process regulated by certain related molecules. Long n...

    Authors: Liang Yang, Xueqiang Peng, Yan Li, Xiaodong Zhang, Yingbo Ma, Chunli Wu, Qing Fan, Shibo Wei, Hangyu Li and Jingang Liu

    Citation: Molecular Cancer 2019 18:78

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  40. Content type: Review

    Neddylation, a post-translational modification that adds an ubiquitin-like protein NEDD8 to substrate proteins, modulates many important biological processes, including tumorigenesis. The process of protein ne...

    Authors: Lisha Zhou, Yanyu Jiang, Qin Luo, Lihui Li and Lijun Jia

    Citation: Molecular Cancer 2019 18:77

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  41. Content type: Letter to the Editor

    Cervical cancer screening through detection and treatment of high-grade cervical intraepithelial neoplasia (CIN) is most successful in cancer prevention. However, the accuracy of the current cervical cancer sc...

    Authors: Mengyue Zheng, Ling Hou, Yu Ma, Lanyun Zhou, Fenfen Wang, Bei Cheng, Wei Wang, Bingjian Lu, Pengyuan Liu, Weiguo Lu and Yan Lu

    Citation: Molecular Cancer 2019 18:76

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  42. Content type: Review

    Tumor-derived exosomes (TDEs) participate in formation and progression of different cancer processes, including tumor microenvironment (TME) remodeling, angiogenesis, invasion, metastasis and drug-resistance. ...

    Authors: Ladan Mashouri, Hassan Yousefi, Amir Reza Aref, Ali mohammad Ahadi, Fatemeh Molaei and Suresh K. Alahari

    Citation: Molecular Cancer 2019 18:75

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  43. Content type: Letter to the Editor

    tRNA-derived small RNA (tsRNA) is a novel regulatory small non-coding RNA and participates in diverse physiological and pathological processes. However, the presence of tsRNAs in exosome and their diagnostic p...

    Authors: Lei Zhu, Jiao Li, Youling Gong, Qingbin Wu, Shuangyan Tan, Dan Sun, Xiaomin Xu, Yuanli Zuo, Yun Zhao, Yu-Quan Wei, Xia-Wei Wei and Yong Peng

    Citation: Molecular Cancer 2019 18:74

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  44. Content type: Research

    As a subclass of noncoding RNAs, circular RNAs (circRNAs) have been demonstrated to play a critical role in regulating gene expression in eukaryotes. Recent studies have revealed the pivotal functions of circR...

    Authors: Yizheng Wu, Ziang Xie, Junxin Chen, Jiaxin Chen, Weiyu Ni, Yan Ma, Kangmao Huang, Gangliang Wang, Jiying Wang, Jianjun Ma, Shuying Shen and Shunwu Fan

    Citation: Molecular Cancer 2019 18:73

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  45. Content type: Correction

    Following publication of the original article [1], the authors reported an error in affiliation 5.

    Authors: Yu-Shui Ma, Tao Huang, Xiao-Ming Zhong, Hong-Wei Zhang, Xian-Ling Cong, Hong Xu, Gai-Xia Lu, Fei Yu, Shao-Bo Xue, Zhong-Wei Lv and Da Fu

    Citation: Molecular Cancer 2019 18:72

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    The original article was published in Molecular Cancer 2018 17:139

  46. Content type: Research

    MicroRNAs (miRs) are involved in lymphoma progression by regulating tumor cell interaction with microenvironment. MiR155 is overexpressed in diffuse large B-cell lymphoma (DLBCL) and its biological effect on t...

    Authors: Zhong Zheng, Rui Sun, Hui-Jin Zhao, Di Fu, Hui-Juan Zhong, Xiang-Qin Weng, Bin Qu, Yan Zhao, Li Wang and Wei-Li Zhao

    Citation: Molecular Cancer 2019 18:54

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