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  1. Neural tumors can generally be divided into central nervous system tumors and peripheral nervous tumors. Because this type of tumor is located in the nerve, even benign tumors are often difficult to remove by ...

    Authors: Yiyang Zheng, Yanyan Luo, Xixi Chen, Huiting Li, Baojun Huang, Baofeng Zhou, Liqing Zhu, Xianhui Kang and Wujun Geng

    Citation: Molecular Cancer 2021 20:49

    Content type: Review

    Published on:

  2. mRNA therapeutics have become the focus of molecular medicine research. Various mRNA applications have reached major milestones at high speed in the immuno-oncology field. This can be attributed to the knowled...

    Authors: Lien Van Hoecke, Rein Verbeke, Heleen Dewitte, Ine Lentacker, Karim Vermaelen, Karine Breckpot and Sandra Van Lint

    Citation: Molecular Cancer 2021 20:48

    Content type: Review

    Published on:

  3. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jingfeng Zhou, Shenglan Liu, Yun Wang, Wei Dai, Hailin Zou, Shubo Wang, Jing Zhang and Jingxuan Pan

    Citation: Molecular Cancer 2021 20:47

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2019 18:159

  4. Hepatocellular carcinoma (HCC) is among the malignancies with the highest mortality. The key regulators and their interactive network in HCC pathogenesis remain unclear. Along with genetic mutations, aberrant ...

    Authors: Junlong Zhao, Huichen Li, Shoujie Zhao, Enxin Wang, Jun Zhu, Dayun Feng, Yejing Zhu, Weijia Dou, Qingling Fan, Jie Hu, Lintao Jia and Lei Liu

    Citation: Molecular Cancer 2021 20:46

    Content type: Research

    Published on:

  5. The tumor suppressor FBW7 is the substrate recognition component of the SCF E3-ubiquitin ligase complex that mediates proteolytic degradation of various oncogenic proteins. However, the role of FBW7 in ovarian...

    Authors: Fei Xu, Jiajia Li, Mengdong Ni, Jingyi Cheng, Haiyun Zhao, Shanshan Wang, Xiang Zhou and Xiaohua Wu

    Citation: Molecular Cancer 2021 20:45

    Content type: Research

    Published on:

  6. Chemotherapeutic resistance is the main cause of clinical treatment failure and poor prognosis in triple-negative breast cancer (TNBC). There is no research on chemotherapeutic resistance in TNBC from the pers...

    Authors: Lei Wang, Yehui Zhou, Liang Jiang, Linlin Lu, Tiantian Dai, Aoshuang Li, Yan Chen and Lifeng Zhang

    Citation: Molecular Cancer 2021 20:43

    Content type: Research

    Published on:

  7. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Xiao Zheng, Lujun Chen, You Zhou, Qi Wang, Zhuojun Zheng, Bin Xu, Chen Wu, Qi Zhou, Wenwei Hu, Changping Wu and Jingting Jiang

    Citation: Molecular Cancer 2021 20:42

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2019 18:47

  8. mRNA vaccines have become a promising platform for cancer immunotherapy. During vaccination, naked or vehicle loaded mRNA vaccines efficiently express tumor antigens in antigen-presenting cells (APCs), facilit...

    Authors: Lei Miao, Yu Zhang and Leaf Huang

    Citation: Molecular Cancer 2021 20:41

    Content type: Review

    Published on:

  9. DNA and RNA can fold into a variety of alternative conformations. In recent years, a particular nucleic acid structure was discussed to play a role in malignant transformation and cancer development. This stru...

    Authors: Nils Kosiol, Stefan Juranek, Peter Brossart, Annkristin Heine and Katrin Paeschke

    Citation: Molecular Cancer 2021 20:40

    Content type: Review

    Published on:

  10. The DEAD-box helicase family member DDX3X (DBX, DDX3) functions in nearly all stages of RNA metabolism and participates in the progression of many diseases, including virus infection, inflammation, intellectua...

    Authors: Jie Mo, Huifang Liang, Chen Su, Pengcheng Li, Jin Chen and Bixiang Zhang

    Citation: Molecular Cancer 2021 20:38

    Content type: Review

    Published on:

  11. Early detection is crucial to improve breast cancer (BC) patients’ outcomes and survival. Mammogram and ultrasound adopting the Breast Imaging Reporting and Data System (BI-RADS) categorization are widely used...

    Authors: Jiaqi Liu, Hengqiang Zhao, Yukuan Huang, Shouping Xu, Yan Zhou, Wei Zhang, Jiaqi Li, Yue Ming, Xinyu Wang, Sen Zhao, Kai Li, Xiying Dong, Yunlong Ma, Tianyi Qian, Xinyi Chen, Zeyu Xing…

    Citation: Molecular Cancer 2021 20:36

    Content type: Letter to the Editor

    Published on:

  12. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Feng Wei, Chengyuan Ma, Tong Zhou, Xuechao Dong, Qinghua Luo, Li Geng, Lijuan Ding, Yandong Zhang, Li Zhang, Nan Li, Yang Li and Yan Liu

    Citation: Molecular Cancer 2021 20:35

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2017 16:132

  13. mRNA vaccines have tremendous potential to fight against cancer and viral diseases due to superiorities in safety, efficacy and industrial production. In recent decades, we have witnessed the development of di...

    Authors: Yang Wang, Ziqi Zhang, Jingwen Luo, Xuejiao Han, Yuquan Wei and Xiawei Wei

    Citation: Molecular Cancer 2021 20:33

    Content type: Review

    Published on:

  14. In the “precision oncology” era the characterization of tumor genetic features is a pivotal step in cancer patients’ management. Liquid biopsy approaches, such as analysis of cell-free DNA from plasma, represe...

    Authors: Filippo Martignano, Uday Munagala, Stefania Crucitta, Alessandra Mingrino, Roberto Semeraro, Marzia Del Re, Iacopo Petrini, Alberto Magi and Silvestro G. Conticello

    Citation: Molecular Cancer 2021 20:32

    Content type: Letter to the Editor

    Published on:

  15. The characterization of circulating tumor cells (CTCs) holds promises for precision medicine because these cells are an important clinical indicator of treatment efficacy. We established the first and still on...

    Authors: Laure Cayrefourcq, Frédéric Thomas, Thibault Mazard, Eric Assenat, Said Assou and Catherine Alix-Panabières

    Citation: Molecular Cancer 2021 20:30

    Content type: Letter to the Editor

    Published on:

  16. The four major RNA adenosine modifications, i.e., m6A, m1A, alternative polyadenylation, and adenosine-to-inosine RNA editing, are mediated mostly by the “writer” enzymes and constitute critical mechanisms of epi...

    Authors: Huifang Chen, Jiameng Yao, Rujuan Bao, Yu Dong, Ting Zhang, Yanhua Du, Gaoyang Wang, Duan Ni, Zhenzhen Xun, Xiaoyin Niu, Youqiong Ye and Hua-Bing Li

    Citation: Molecular Cancer 2021 20:29

    Content type: Research

    Published on:

  17. The overlapping metabolic reprogramming of cancer and immune cells is a putative determinant of the antitumor immune response in cancer. Increased evidence suggests that cancer metabolism not only plays a cruc...

    Authors: Longzheng Xia, Linda Oyang, Jinguan Lin, Shiming Tan, Yaqian Han, Nayiyuan Wu, Pin Yi, Lu Tang, Qing Pan, Shan Rao, Jiaxin Liang, Yanyan Tang, Min Su, Xia Luo, Yiqing Yang, Yingrui Shi…

    Citation: Molecular Cancer 2021 20:28

    Content type: Review

    Published on:

  18. The development of immune checkpoint blockade (ICB)-based immunotherapy has dramatically changed methods of cancer treatment. This approach triggers a durable treatment response and prolongs patients' survival...

    Authors: Jun-Yan Li, Yu-Pei Chen, Ying-Qin Li, Na Liu and Jun Ma

    Citation: Molecular Cancer 2021 20:27

    Content type: Review

    Published on:

  19. Colorectal cancer (CRC) is a common hereditary tumor that is often fatal. Its pathogenesis involves multiple genes, including circular RNAs (circRNAs). Notably, circRNAs constitute a new class of noncoding RNA...

    Authors: Fei Long, Zhi Lin, Liang Li, Min Ma, Zhixing Lu, Liang Jing, Xiaorong Li and Changwei Lin

    Citation: Molecular Cancer 2021 20:26

    Content type: Review

    Published on:

  20. E3 ubiquitin ligase HRD1 (HMG-CoA reductase degradation protein 1, alias synoviolin with SYVN1 as the official gene symbol) was found downregulated and acting as a tumor suppressor in breast cancer, while the ...

    Authors: Ya Fan, Jia Wang, Wen Jin, Yifei Sun, Yuemei Xu, Yipin Wang, Xiubin Liang and Dongming Su

    Citation: Molecular Cancer 2021 20:25

    Content type: Research

    Published on:

  21. Noncoding RNA (ncRNA) transcripts that did not code proteins but regulate their functions were extensively studied for the last two decades and the plethora of discoveries have instigated scientists to investi...

    Authors: Swati Mohapatra, Carlotta Pioppini, Bulent Ozpolat and George A. Calin

    Citation: Molecular Cancer 2021 20:24

    Content type: Review

    Published on:

  22. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yann Cheli, Meri K. Tulic, Najla El Hachem, Nicolas Nottet, Arnaud Jacquel, Maeva Gesson, Thomas Strub, Karine Bille, Alexandra Picard-Gauci, Henri Montaudié, Guillaume E. Beranger, Thierry Passeron, Pierre Close, Corine Bertolotto and Robert Ballotti

    Citation: Molecular Cancer 2021 20:21

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2021 20:12

  23. Hepatocellular carcinoma (HCC) is one of the most common human malignancies worldwide with very poor prognosis. Resistance to targeted therapeutic drugs such as sorafenib remains one of the major challenges in...

    Authors: Xiao-Dong Yang, Fan-En Kong, Ling Qi, Jia-Xin Lin, Qian Yan, Jane Ho Chun Loong, Shao-Yan Xi, Yue Zhao, Yan Zhang, Yun-Fei Yuan, Ning-Fang Ma, Stephanie Ma, Xin-Yuan Guan and Ming Liu

    Citation: Molecular Cancer 2021 20:20

    Content type: Letter to the Editor

    Published on:

  24. There is increasing evidence that circular RNAs (circRNAs) have significant regulatory roles in cancer development and progression; however, the expression patterns and biological functions of circRNAs in rena...

    Authors: Junjie Cen, Yanping Liang, Yong Huang, Yihui Pan, Guannan Shu, Zhousan Zheng, Xiaozhong Liao, Mi Zhou, Danlei Chen, Yong Fang, Wei Chen, Junhang Luo and Jiaxing Zhang

    Citation: Molecular Cancer 2021 20:19

    Content type: Research

    Published on:

  25. Epidermal growth factor receptor (EGFR)-mutated lung cancer constitutes a major subgroup of non-small cell lung cancer (NSCLC) and osimertinib is administrated as first-line treatment. However, most patients w...

    Authors: Shaocong Wu, Min Luo, Kenneth K. W. To, Jianye Zhang, Chaoyue Su, Hong Zhang, Sainan An, Fang Wang, Da Chen and Liwu Fu

    Citation: Molecular Cancer 2021 20:17

    Content type: Research

    Published on:

  26. The IκB kinase (IKK) complex, comprising the two enzymes IKKα and IKKβ, is the main activator of the inflammatory transcription factor NF-κB, which is constitutively active in many cancers. While several conne...

    Authors: Bernhard Moser, Bernhard Hochreiter, José Basílio, Viola Gleitsmann, Anja Panhuber, Alan Pardo-Garcia, Bastian Hoesel, Manuel Salzmann, Ulrike Resch, Mamoona Noreen and Johannes A. Schmid

    Citation: Molecular Cancer 2021 20:16

    Content type: Research

    Published on:

  27. Currently, there is no strong evidence of the well-established biomarkers for immune checkpoint inhibitors (ICIs) in nasopharyngeal carcinoma (NPC). Here, we aimed to reveal the heterogeneity of tumour microen...

    Authors: Yu-Pei Chen, Jia-Wei Lv, Yan-Ping Mao, Xiao-Min Li, Jun-Yan Li, Ya-Qin Wang, Cheng Xu, Ying-Qin Li, Qing-Mei He, Xiao-Jing Yang, Yuan Lei, Jia-Yi Shen, Ling-Long Tang, Lei Chen, Guan-Qun Zhou, Wen-Fei Li…

    Citation: Molecular Cancer 2021 20:14

    Content type: Letter

    Published on:

  28. Cancer is a leading cause of death worldwide, particularly because of its high mortality rate in patients who are diagnosed at late stages. Conventional biomarkers originating from blood are widely used for ca...

    Authors: Sumeng Wang, Ke Zhang, Shanyue Tan, Junyi Xin, Qianyu Yuan, Huanhuan Xu, Xian Xu, Qi Liang, David C. Christiani, Meilin Wang, Lingxiang Liu and Mulong Du

    Citation: Molecular Cancer 2021 20:13

    Content type: Review

    Published on:

  29. Resistances to immunotherapies remains a major hurdle towards a cure for melanoma in numerous patients. An increase in the mesenchymal phenotype and a loss of differentiation have been clearly associated with ...

    Authors: Yann Cheli, Meri K. Tulic, Najla El Hachem, Nicolas Nottet, Arnaud Jacquel, Maeva Gesson, Thomas Strub, Karine Bille, Alexandra Picard-Gauci, Henri Montaudié, Guillaume E. Beranger, Thierry Passeron, Pierre Close, Corine Bertolotto and Robert Ballotti

    Citation: Molecular Cancer 2021 20:12

    Content type: Letter to the Editor

    Published on:

    The Correction to this article has been published in Molecular Cancer 2021 20:21

  30. Emerging evidence has revealed that the removal of N-linked glycosylation could enhance PD-L1 detection. However, whether PD-L1 antibodies against different epitopes of PD-L1 antigens responding to deglycosyla...

    Authors: Jie Mei, Junying Xu, Xuejing Yang, Dingyi Gu, Weijian Zhou, Huiyu Wang and Chaoying Liu

    Citation: Molecular Cancer 2021 20:11

    Content type: Letter to the Editor

    Published on:

  31. FOLFOX is a combinational regimen of folinic acid (FnA, FOL), fluorouracil (5-Fu, F) and oxaliplatin (OxP, OX), and has been long considered as the standard treatment of colorectal cancer (CRC) and hepatocellular...

    Authors: Jianfeng Guo, Zhuo Yu, Dandan Sun, Yifang Zou, Yun Liu and Leaf Huang

    Citation: Molecular Cancer 2021 20:10

    Content type: Research

    Published on:

  32. MicroRNAs (miRNAs) show considerable promise as therapeutic agents to improve tumor treatment, as they have been revealed as crucial modulators in tumor progression. However, our understanding of their roles i...

    Authors: Shan Xing, Zhi Tian, Wenying Zheng, Wenjuan Yang, Nan Du, Yixue Gu, Jiang Yin, Hao Liu, Xiaoting Jia, Donglan Huang, Wanli Liu and Min Deng

    Citation: Molecular Cancer 2021 20:9

    Content type: Research

    Published on:

  33. Acute myeloid leukemia (AML) is still incurable due to its heterogeneity and complexity of tumor microenvironment. It is imperative therefore to understand the molecular pathogenesis of AML and identify leukem...

    Authors: Yu-Jun Dai, Si-Yuan He, Fang Hu, Xue-Ping Li, Jian-Ming Zhang, Si-Liang Chen, Wei-Na Zhang, Hai-Min Sun and Da-Wei Wang

    Citation: Molecular Cancer 2021 20:8

    Content type: Letter to the Editor

    Published on:

  34. Vasculogenic mimicry (VM) is a recently discovered angiogenetic process found in many malignant tumors, and is different from the traditional angiogenetic process involving vascular endothelium. It involves th...

    Authors: Xiaoxu Wei, Yunhua Chen, Xianjie Jiang, Miao Peng, Yiduo Liu, Yongzhen Mo, Daixi Ren, Yuze Hua, Boyao Yu, Yujuan Zhou, Qianjin Liao, Hui Wang, Bo Xiang, Ming Zhou, Xiaoling Li, Guiyuan Li…

    Citation: Molecular Cancer 2021 20:7

    Content type: Review

    Published on:

  35. De novo and acquired resistance, which are mainly mediated by genetic alterations, are barriers to effective routine chemotherapy. However, the mechanisms underlying gastric cancer (GC) resistance to chemother...

    Authors: Feifei Zhang, Hui Wang, Jiang Yu, Xueqing Yao, Shibin Yang, Weidong Li, Lijun Xu and Liang Zhao

    Citation: Molecular Cancer 2021 20:6

    Content type: Letter to the Editor

    Published on:

  36. Cytokine release syndrome (CRS) is a systemic inflammatory response characterized by the overexpression of inflammatory genes. Controlling CRS is essential for improving the therapeutic effects of chimeric ant...

    Authors: Ye Wei, Chong Li, Huifang Bian, Wei Qian, Kairui Jin, Tingting Xu, Xiaomao Guo, Xueguan Lu and Fengtao Su

    Citation: Molecular Cancer 2021 20:5

    Content type: Research

    Published on:

  37. Circular RNAs (circRNAs), which are single-stranded closed-loop RNA molecules lacking terminal 5′ caps and 3′ poly(A) tails, are attracting increasing scientific attention for their crucial regulatory roles in...

    Authors: Xiaoqi Yang, Tao Ye, Haoran Liu, Peng Lv, Chen Duan, Xiaoliang Wu, Kehua Jiang, Hongyan Lu, Ding Xia, Ejun Peng, Zhiqiang Chen, Kun Tang and Zhangqun Ye

    Citation: Molecular Cancer 2021 20:4

    Content type: Review

    Published on:

  38. c-Myc is a transcription factor that is constitutively and aberrantly expressed in over 70% of human cancers. Its direct inhibition has been shown to trigger rapid tumor regression in mice with only mild and f...

    Authors: Sarah K. Madden, Aline Dantas de Araujo, Mara Gerhardt, David P. Fairlie and Jody M. Mason

    Citation: Molecular Cancer 2021 20:3

    Content type: Review

    Published on:

  39. Esophageal cancer (EC) is a disease often marked by aggressive growth and poor prognosis. Lack of targeted therapies, resistance to chemoradiation therapy, and distant metastases among patients with advanced d...

    Authors: Ajaz A. Bhat, Sabah Nisar, Selma Maacha, Tatiana Correa Carneiro-Lobo, Sabah Akhtar, Kodappully Sivaraman Siveen, Nissar A. Wani, Arshi Rizwan, Puneet Bagga, Mayank Singh, Ravinder Reddy, Shahab Uddin, Jean-Charles Grivel, Gyan Chand, Michael P. Frenneaux, Mushtaq A. Siddiqi…

    Citation: Molecular Cancer 2021 20:2

    Content type: Review

    Published on:

  40. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Ajaz A. Bhat, Salma N. Younes, Syed Shadab Raza, Lubna Zarif, Sabah Nisar, Ikhlak Ahmed, Rashid Mir, Sachin Kumar, Surender K. Sharawat, Sheema Hashem, Imadeldin Elfaki, Michal Kulinski, Shilpa Kuttikrishnan, Kirti S. Prabhu, Abdul Q. Khan, Santosh K. Yadav…

    Citation: Molecular Cancer 2020 19:174

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2020 19:57

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