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Review
Circular RNAs, a novel class of endogenous noncoding RNAs, are characterized by their covalently closed loop structures without a 5′ cap or a 3′ Poly A tail. Although the mechanisms of circular RNAs’ generatio...
Molecular Cancer 2017 16:94
Published on: 23 May 2017
Research
The MET receptor tyrosine kinase represents a promising target in cancer. PIK3CA activating mutations are common in several tumor types and can potentially confer resistance to anti-receptor tyrosine kinase th...
Molecular Cancer 2017 16:93
Published on: 22 May 2017
Review
Ovarian cancer (OC) is one of the three types of malignant tumors in the female reproductive system, and epithelial ovarian cancer (EOC) is its most typical form. Due to the asymptomatic nature of the early st...
Molecular Cancer 2017 16:92
Published on: 15 May 2017
Research
Nutrient deprivation, hypoxia, radiotherapy and chemotherapy induce endoplasmic reticulum (ER) stress, which activates the so-called unfolded protein response (UPR). Extensive and acute ER stress directs the U...
Molecular Cancer 2017 16:91
Published on: 12 May 2017
Research
Hematological and neurological expressed 1 (HN1) is upregulated in many tumors, but the role of HN1 in breast cancer progression and its regulatory mechanism have not been well understood.
Molecular Cancer 2017 16:90
Published on: 11 May 2017
Research
The inhibitor of growth (ING) gene family of tumor suppressors is involved in multiple cellular functions such as cell cycle regulation, apoptosis, and chromatin remodeling. ING5 is a new member of the ING fam...
Molecular Cancer 2017 16:89
Published on: 10 May 2017
Research
Thymoma and thymic carcinoma are the most frequent subtypes of thymic epithelial tumors (TETs). A relevant advance in TET management could derive from a deeper molecular characterization of these neoplasms. We...
Molecular Cancer 2017 16:88
Published on: 10 May 2017
Research
Estrogenic signals are suggested to have protection roles in the development of colorectal cancer (CRC). The G protein-coupled estrogen receptor (GPER) has been reported to mediate non-genomic effects of estro...
Molecular Cancer 2017 16:87
Published on: 5 May 2017
Research
The BRAF protein kinase is widely studied as a cancer driver and therapeutic target. However, the regulation of its expression is not completely understood.
Molecular Cancer 2017 16:85
Published on: 28 April 2017
Research
Enhancing the antitumor activity of the DNA-damaging drugs is an attractive strategy to improve current treatment options. Trabectedin is an isoquinoline alkylating agent with a peculiar mechanism of action. I...
Molecular Cancer 2017 16:86
Published on: 28 April 2017
Research
Long noncoding RNAs (lncRNAs) have emerged as critical regulators in a variety of human cancers, including gastric cancer (GC). However, the function and mechanisms responsible for these molecules in GC are no...
Molecular Cancer 2017 16:82
Published on: 26 April 2017
Research
Cancer/testis (CT) genes have expression normally restricted to the testis, but become activated during oncogenesis, so they have excellent potential as cancer-specific biomarkers. Evidence is starting to emer...
Molecular Cancer 2017 16:84
Published on: 26 April 2017
Research
Both mTOR and Skp2 play critical roles in gastric cancer (GC) tumorigenesis. However, potential mechanisms for the association between these two proteins remains unidentified.
Molecular Cancer 2017 16:83
Published on: 26 April 2017
Research
Esophageal squamous cell carcinoma (ESCC) is highly malignant with highly invasive and metastatic capabilities and poor prognosis. It is believed that the ESCC cancer stem-like cells (ECSLCs) are critical for ...
Molecular Cancer 2017 16:81
Published on: 21 April 2017
Review
There is a growing trend towards exploring the use of a minimally invasive “liquid biopsy” to identify biomarkers in a number of cancers, including urologic malignancies. Multiple aspects can be assessed in ci...
Molecular Cancer 2017 16:80
Published on: 14 April 2017
Review
Cancer cells are frequently confronted with metabolic stress in tumor microenvironments due to their rapid growth and limited nutrient supply. Metabolic stress induces cell death through ROS-induced apoptosis....
Molecular Cancer 2017 16:79
Published on: 13 April 2017
Research
Profiling evidences of selectin demonstrate that they play an crucial role in cancer progression and metastasis. However, DC-SIGNR as a family member of selectin participates in gastric cancer liver metastasis...
Molecular Cancer 2017 16:78
Published on: 13 April 2017
Review
Cancer cells frequently display fundamentally altered cellular metabolism, which provides the biochemical foundation and directly contributes to tumorigenicity and malignancy. Rewiring of metabolic programmes,...
Molecular Cancer 2017 16:76
Published on: 11 April 2017
Research
Gastric cancer (GC) is one of the frequent causes of cancer-related death in eastern Asian population. IGF2BP2 lists in the top rank up-regulated genes in GC, but its functional role is unclear.
Molecular Cancer 2017 16:77
Published on: 11 April 2017
Short communication
Early diagnosis of esophageal squamous cell carcinoma (ESCC) is an important issue to improve the prognosis. HOX transcript antisense RNA (HOTAIR), a long noncoding RNA (lncRNA) expressed from the HOXC locus, ...
Molecular Cancer 2017 16:75
Published on: 4 April 2017
Research
The telomerase/telomere interacting protein PinX1 has been suggested as a tumor suppressor. However, the clinical and biological significance of PinX1 in human non-small cell lung cancer (NSCLC) is unclear.
Molecular Cancer 2017 16:74
Published on: 4 April 2017
Research
The role of cancer-associated fibroblasts (CAFs) during tumour progression is obscured by the inherently complex, heterotypic nature of fibroblast cells and behaviours in various subtypes of malignancies. Ther...
Molecular Cancer 2017 16:73
Published on: 3 April 2017
Research
Vascular endothelial growth factor receptors (VEGFRs) are the major receptors involved in endothelial cell-dependent tumor angiogenesis. There are studies account for the effects of Hsp90 on angiogenesis, but ...
Molecular Cancer 2017 16:72
Published on: 31 March 2017
Research
Although chemotherapy represents a predominant anti-cancer therapeutic modality, drug treatment efficacy is often limited due to the development of resistant tumor cells. The pregnane X receptor (PXR) affects ...
Molecular Cancer 2017 16:71
Published on: 29 March 2017
Research
Metastasis is a major cause of death in human colorectal cancer patients. However, the contribution of chemokines in the tumor microenvironment to tumor metastasis is not fully understood.
Molecular Cancer 2017 16:70
Published on: 29 March 2017
