Articles

CircMEMO1 modulates the promoter methylation and expression of TCF21 to regulate hepatocellular carcinoma progression and sorafenib treatment sensitivity

Cirrhosis is a recognized risk factor for developing hepatocellular carcinoma (HCC). Few studies have reported the expression profile of circRNAs in HCC samples compared to paratumour dysplastic nodule (DN) sa...

Authors: Zhao-Ru Dong, Ai-Wu Ke, Tao Li, Jia-Bing Cai, Ya-fei Yang, Wei Zhou, Guo-Ming Shi and Jia Fan

Pals1 prevents Rac1-dependent colorectal cancer cell metastasis by inhibiting Arf6

Loss of apical-basal polarity and downregulation of cell-cell contacts is a critical step during the pathogenesis of cancer. Both processes are regulated by the scaffolding protein Pals1, however, it is unclea...

Authors: Simona Mareike Lüttgenau, Christin Emming, Thomas Wagner, Julia Harms, Justine Guske, Katrin Weber, Ute Neugebauer, Rita Schröter, Olga Panichkina, Zoltán Pethő, Florian Weber, Albrecht Schwab, Anja Kathrin Wege, Pavel Nedvetsky and Michael P. Krahn

Cancer-associated fibroblast-derived gene signatures determine prognosis in colon cancer patients

Authors: Mercedes Herrera, Alberto Berral-González, Igor López-Cade, Cristina Galindo-Pumariño, Santiago Bueno-Fortes, Manuel Martín-Merino, Alfredo Carrato, Alberto Ocaña, Carolina De La Pinta, Ana López-Alfonso, Cristina Peña, Vanesa García-Barberán and Javier De Las Rivas

Nonsense-mediated RNA decay and its bipolar function in cancer

Nonsense-mediated decay (NMD) was first described as a quality-control mechanism that targets and rapidly degrades aberrant mRNAs carrying premature termination codons (PTCs). However, it was found that NMD al...

Authors: Gonçalo Nogueira, Rafael Fernandes, Juan F. García-Moreno and Luísa Romão

The role and application of small extracellular vesicles in gastric cancer

Gastric cancer (GC) is a common tumour that affects humans worldwide, is highly malignant and has a poor prognosis. Small extracellular vesicles (sEVs), especially exosomes, are nanoscale vesicles released by ...

Authors: Hao Wu, Mengdi Fu, Jin Liu, Wei Chong, Zhen Fang, Fengying Du, Yang Liu, Liang Shang and Leping Li

CircLIFR synergizes with MSH2 to attenuate chemoresistance via MutSα/ATM-p73 axis in bladder cancer

Cisplatin (CDDP) has become a standard-of-care treatment for muscle-invasive bladder cancer (MIBC), while chemoresistance remains a major challenge. Accumulating evidence indicates that circular RNAs (circRNAs...

Authors: Hui Zhang, Xingyuan Xiao, Wenjie Wei, Chao Huang, Miao Wang, Liang Wang, Yuanqiao He, Jiayin Sun, Yangkai Jiang, Guosong Jiang and Xiaoping Zhang

mRNA therapeutics in cancer immunotherapy

Synthetic mRNA provides a template for the synthesis of any given protein, protein fragment or peptide and lends itself to a broad range of pharmaceutical applications, including different modalities of cancer...

Authors: Jan D. Beck, Daniel Reidenbach, Nadja Salomon, Ugur Sahin, Özlem Türeci, Mathias Vormehr and Lena M. Kranz

CircPTPRA blocks the recognition of RNA N⁶-methyladenosine through interacting with IGF2BP1 to suppress bladder cancer progression

Circular RNAs (circRNAs) have been found to have significant impacts on bladder cancer (BC) progression through various mechanisms. In this study, we aimed to identify novel circRNAs that regulate the function...

Authors: Fei Xie, Chao Huang, Feng Liu, Hui Zhang, Xingyuan Xiao, Jiayin Sun, Xiaoping Zhang and Guosong Jiang

Comprehensive analyses of m6A regulators and interactive coding and non-coding RNAs across 32 cancer types

N6-Methyladenosine (m6A) is an RNA modification that interacts with numerous coding and non-coding RNAs and plays important roles in the development of cancers. Nonetheless, the clinical impacts of m6A interac...

Authors: Sipeng Shen, Ruyang Zhang, Yue Jiang, Yi Li, Lijuan Lin, Zhonghua Liu, Yang Zhao, Hongbing Shen, Zhibin Hu, Yongyue Wei and Feng Chen

A novel protein encoded by circMAPK1 inhibits progression of gastric cancer by suppressing activation of MAPK signaling

A novel type of noncoding RNA, circRNA has been reported to participate in the occurrence and development of diseases through many mechanisms. The MAPK pathway is a common signal transduction pathway involved ...

Authors: Tianlu Jiang, Yiwen Xia, Jialun Lv, Bowen Li, Ying Li, Sen Wang, Zhe Xuan, Li Xie, Shengkui Qiu, Zhongyuan He, Linjun Wang and Zekuan Xu

Correction to: LMTK3 inhibition affects microtubule Stability

An amendment to this paper has been published and can be accessed via the original article.

Authors: Chiara Cilibrasi, Angeliki Ditsiou, Athanasios Papakyriakou, George Mavridis, Murat Eravci, Justin Stebbing, Teresa Gagliano and Georgios Giamas

Correction to: LncRNA PTAR promotes EMT and invasionmetastasis in serous ovarian cancer by competitively binding miR-101-3p to regulate ZEB1 expression

An amendment to this paper has been published and can be accessed via the original article.

Authors: Haihai Liang, Tong Yu, Yue Han, Hua Jiang, Chengyu Wang, Tianyi You, Xiaoguang Zhao, Huitong Shan, Rui Yang, Lida Yang, Hongli Shan and Yunyan Gu

An integrative functional genomics approach reveals EGLN1 as a novel therapeutic target in KRAS mutated lung adenocarcinoma

Authors: Francesca Reggiani, Elisabetta Sauta, Federica Torricelli, Eleonora Zanetti, Elena Tagliavini, Giacomo Santandrea, Giulia Gobbi, Giovanna Damia, Riccardo Bellazzi, Davide Ambrosetti, Alessia Ciarrocchi and Valentina Sancisi

Targeting CXCR2 inhibits the progression of lung cancer and promotes therapeutic effect of cisplatin

Drug-resistance and severe side effects of chemotherapeutic agents result in unsatisfied survival of patients with lung cancer. CXCLs/CXCR2 axis plays an important role in progression of cancer including lung ...

Authors: Yuan Cheng, Fei Mo, Qingfang Li, Xuejiao Han, Houhui Shi, Siyuan Chen, Yuquan Wei and Xiawei Wei

The m⁶A RNA methylation regulates oncogenic signaling pathways driving cell malignant transformation and carcinogenesis

The m⁶A RNA methylation is the most prevalent internal modification in mammalian mRNAs which plays critical biological roles by regulating vital cellular processes. Dysregulations of the m⁶A modification due to a...

Authors: Mohammad Burhan Uddin, Zhishan Wang and Chengfeng Yang

Correction to: CircLONP2 enhances colorectal carcinoma invasion and metastasis through modulating the maturation and exosomal dissemination of microRNA-17

An amendment to this paper has been published and can be accessed via the original article.

Authors: Kai Han, Feng-Wei Wang, Chen-Hui Cao, Han Ling, Jie-Wei Chen, Ri-Xin Chen, Zi-Hao Feng, Jie Luo, Xiao-Han Jin, Jin-Ling Duan, Shu-Man Li, Ning-Fang Ma, Jing-Ping Yun, Xin-Yuan Guan, Zhi-Zhong Pan, Ping Lan…

Platelets, immune cells and the coagulation cascade; friend or foe of the circulating tumour cell?

Cancer cells that transit from primary tumours into the circulatory system are known as circulating tumour cells (CTCs). These cancer cells have unique phenotypic and genotypic characteristics which allow them...

Authors: Mark P. Ward, Laura E. Kane, Lucy A. Norris, Bashir M. Mohamed, Tanya Kelly, Mark Bates, Andres Clarke, Nathan Brady, Cara M. Martin, Robert D. Brooks, Doug A. Brooks, Stavros Selemidis, Sean Hanniffy, Eric P. Dixon, Sharon A. O’Toole and John J. O’Leary

Circulating exosomal mRNA profiling identifies novel signatures for the detection of prostate cancer

The landscape and characteristics of circulating exosomal messenger RNAs (emRNAs) are poorly understood, which hampered the accurate detection of circulating emRNAs. Through comparing RNA sequencing data of ci...

Authors: Jin Ji, Rui Chen, Lin Zhao, Yalong Xu, Zhi Cao, Huan Xu, Xi Chen, Xiaolei Shi, Yasheng Zhu, Ji Lyu, Junfeng Jiang, Yue Wang, Tie Zhou, Jingyi He, Xuedong Wei, Jason Boyang Wu…

Plasma-derived exosomal miR-15a-5p as a promising diagnostic biomarker for early detection of endometrial carcinoma

Endometrial cancer (EC) is a major cause of death among gynecologic malignancies. To improve early detection of EC in patients, we carried out a large plasma-derived exosomal microRNA (miRNA) studies for diagn...

Authors: Lanyun Zhou, Wei Wang, Fenfen Wang, Siqi Yang, Jiaqi Hu, Bingjian Lu, Zimin Pan, Yu Ma, Mengyue Zheng, Liyuan Zhou, Shufeng Lei, Penghong Song, Pengyuan Liu, Weiguo Lu and Yan Lu

Correction to: LncRNA PVT1 up-regulation is a poor prognosticator and serves as a therapeutic target in esophageal adenocarcinoma

An amendment to this paper has been published and can be accessed via the original article.

Authors: Yan Xu, Yuan Li, Jiankang Jin, Guangchun Han, Chengcao Sun, Melissa Pool Pizzi, Longfei Huo, Ailing Scott, Ying Wang, Lang Ma, Jeffrey H. Lee, Manoop S. Bhutani, Brian Weston, Christopher Vellano, Liuqing Yang, Chunru Lin…

Delivery of cancer therapies by synthetic and bio-inspired nanovectors

As a complement to the clinical development of new anticancer molecules, innovations in therapeutic vectorization aim at solving issues related to tumor specificity and associated toxicities. Nanomedicine is a...

Authors: Tina Briolay, Tacien Petithomme, Morgane Fouet, Nelly Nguyen-Pham, Christophe Blanquart and Nicolas Boisgerault

RNA-based therapies: A cog in the wheel of lung cancer defense

Lung cancer (LC) is a heterogeneous disease consisting mainly of two subtypes, non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC), and remains the leading cause of death worldwide. Despite re...

Authors: Parvez Khan, Jawed Akhtar Siddiqui, Imayavaramban Lakshmanan, Apar Kishor Ganti, Ravi Salgia, Maneesh Jain, Surinder Kumar Batra and Mohd Wasim Nasser

LMTK3 inhibition affects microtubule stability

Authors: Chiara Cilibrasi, Angeliki Ditsiou, Athanasios Papakyriakou, George Mavridis, Murat Eravci, Justin Stebbing, Teresa Gagliano and Georgios Giamas

Clinical and immunological effects of mRNA vaccines in malignant diseases

In vitro-transcribed messenger RNA-based therapeutics represent a relatively novel and highly efficient class of drugs. Several recently published studies emphasize the potential efficacy of mRNA vaccines in trea...

Authors: Annkristin Heine, Stefan Juranek and Peter Brossart

CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing

A growing number of studies have focused on investigating circRNAs as crucial regulators in the progression of multiple cancer types. Nevertheless, the biological effects and underlying mechanisms of circRNAs ...

Authors: Peng Shen, Taoyue Yang, Qun Chen, Hao Yuan, Pengfei Wu, Baobao Cai, Lingdong Meng, Xumin Huang, Jiaye Liu, Yihan Zhang, Weikang Hu, Yi Miao, Zipeng Lu and Kuirong Jiang

Identification of tumor antigens and immune subtypes of cholangiocarcinoma for mRNA vaccine development

The mRNA-based cancer vaccine has been considered a promising strategy and the next hotspot in cancer immunotherapy. However, its application on cholangiocarcinoma remains largely uncharacterized. This study a...

Authors: Xing Huang, Tianyu Tang, Gang Zhang and Tingbo Liang

The role of mRNA in the development, diagnosis, treatment and prognosis of neural tumors

Neural tumors can generally be divided into central nervous system tumors and peripheral nervous tumors. Because this type of tumor is located in the nerve, even benign tumors are often difficult to remove by ...

Authors: Yiyang Zheng, Yanyan Luo, Xixi Chen, Huiting Li, Baojun Huang, Baofeng Zhou, Liqing Zhu, Xianhui Kang and Wujun Geng

mRNA in cancer immunotherapy: beyond a source of antigen

mRNA therapeutics have become the focus of molecular medicine research. Various mRNA applications have reached major milestones at high speed in the immuno-oncology field. This can be attributed to the knowled...

Authors: Lien Van Hoecke, Rein Verbeke, Heleen Dewitte, Ine Lentacker, Karim Vermaelen, Karine Breckpot and Sandra Van Lint

Correction to: Salinomycin effectively eliminates cancer stem-like cells and obviates hepatic metastasis in uveal melanoma

An amendment to this paper has been published and can be accessed via the original article.

Authors: Jingfeng Zhou, Shenglan Liu, Yun Wang, Wei Dai, Hailin Zou, Shubo Wang, Jing Zhang and Jingxuan Pan

Epigenetic silencing of miR-144/451a cluster contributes to HCC progression via paracrine HGF/MIF-mediated TAM remodeling

Hepatocellular carcinoma (HCC) is among the malignancies with the highest mortality. The key regulators and their interactive network in HCC pathogenesis remain unclear. Along with genetic mutations, aberrant ...

Authors: Junlong Zhao, Huichen Li, Shoujie Zhao, Enxin Wang, Jun Zhu, Dayun Feng, Yejing Zhu, Weijia Dou, Qingling Fan, Jie Hu, Lintao Jia and Lei Liu

FBW7 suppresses ovarian cancer development by targeting the N⁶-methyladenosine binding protein YTHDF2

The tumor suppressor FBW7 is the substrate recognition component of the SCF E3-ubiquitin ligase complex that mediates proteolytic degradation of various oncogenic proteins. However, the role of FBW7 in ovarian...

Authors: Fei Xu, Jiajia Li, Mengdong Ni, Jingyi Cheng, Haiyun Zhao, Shanshan Wang, Xiang Zhou and Xiaohua Wu

Identification of tumor antigens and immune subtypes of pancreatic adenocarcinoma for mRNA vaccine development

Although mRNA vaccines have been effective against multiple cancers, their efficacy against pancreatic adenocarcinoma (PAAD) remains undefined. Accumulating evidence suggests that immunotyping can indicate the...

Authors: Xing Huang, Gang Zhang, Tianyu Tang and Tingbo Liang

CircWAC induces chemotherapeutic resistance in triple-negative breast cancer by targeting miR-142, upregulating WWP1 and activating the PI3K/AKT pathway

Chemotherapeutic resistance is the main cause of clinical treatment failure and poor prognosis in triple-negative breast cancer (TNBC). There is no research on chemotherapeutic resistance in TNBC from the pers...

Authors: Lei Wang, Yehui Zhou, Liang Jiang, Linlin Lu, Tiantian Dai, Aoshuang Li, Yan Chen and Lifeng Zhang

Correction to: A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling

An amendment to this paper has been published and can be accessed via the original article.

Authors: Xiao Zheng, Lujun Chen, You Zhou, Qi Wang, Zhuojun Zheng, Bin Xu, Chen Wu, Qi Zhou, Wenwei Hu, Changping Wu and Jingting Jiang

mRNA vaccine for cancer immunotherapy

mRNA vaccines have become a promising platform for cancer immunotherapy. During vaccination, naked or vehicle loaded mRNA vaccines efficiently express tumor antigens in antigen-presenting cells (APCs), facilit...

Authors: Lei Miao, Yu Zhang and Leaf Huang

G-quadruplexes: a promising target for cancer therapy

DNA and RNA can fold into a variety of alternative conformations. In recent years, a particular nucleic acid structure was discussed to play a role in malignant transformation and cancer development. This stru...

Authors: Nils Kosiol, Stefan Juranek, Peter Brossart, Annkristin Heine and Katrin Paeschke

Liquid biopsy proteomics of uveal melanoma reveals biomarkers associated with metastatic risk

Authors: Gabriel Velez, Huy V. Nguyen, Teja Chemudupati, Cassie A. Ludwig, Marcus Toral, Sunil Reddy, Prithvi Mruthyunjaya and Vinit B. Mahajan

DDX3X: structure, physiologic functions and cancer

The DEAD-box helicase family member DDX3X (DBX, DDX3) functions in nearly all stages of RNA metabolism and participates in the progression of many diseases, including virus infection, inflammation, intellectua...

Authors: Jie Mo, Huifang Liang, Chen Su, Pengcheng Li, Jin Chen and Bixiang Zhang

Intratumoral heterogeneity as a predictive biomarker in anti-PD-(L)1 therapies for non-small cell lung cancer

Authors: Wenfeng Fang, Haoxuan Jin, Huaqiang Zhou, Shaodong Hong, Yuxiang Ma, Yaxiong Zhang, Xiaofan Su, Longyun Chen, Yunpeng Yang, Shengqiang Xu, Yuwei Liao, Yuming He, Hongyun Zhao, Yan Huang, Zhibo Gao and Li Zhang

Genome-wide cell-free DNA methylation analyses improve accuracy of non-invasive diagnostic imaging for early-stage breast cancer

Early detection is crucial to improve breast cancer (BC) patients’ outcomes and survival. Mammogram and ultrasound adopting the Breast Imaging Reporting and Data System (BI-RADS) categorization are widely used...

Authors: Jiaqi Liu, Hengqiang Zhao, Yukuan Huang, Shouping Xu, Yan Zhou, Wei Zhang, Jiaqi Li, Yue Ming, Xinyu Wang, Sen Zhao, Kai Li, Xiying Dong, Yunlong Ma, Tianyi Qian, Xinyi Chen, Zeyu Xing…

Correction to: Exosomes derived from gemcitabine resistant cells transfer malignant phenotypic traits via delivery of miRNA-222-3p

An amendment to this paper has been published and can be accessed via the original article.

Authors: Feng Wei, Chengyuan Ma, Tong Zhou, Xuechao Dong, Qinghua Luo, Li Geng, Lijuan Ding, Yandong Zhang, Li Zhang, Nan Li, Yang Li and Yan Liu

Coupled liquid biopsy and bioinformatics for pancreatic cancer early detection and precision prognostication

Early detection and diagnosis are the key to successful clinical management of pancreatic cancer and improve the patient outcome. However, due to the absence of early symptoms and the aggressiveness of pancrea...

Authors: Jun Hou, XueTao Li and Ke-Ping Xie

mRNA vaccine: a potential therapeutic strategy

mRNA vaccines have tremendous potential to fight against cancer and viral diseases due to superiorities in safety, efficacy and industrial production. In recent decades, we have witnessed the development of di...

Authors: Yang Wang, Ziqi Zhang, Jingwen Luo, Xuejiao Han, Yuquan Wei and Xiawei Wei

Nanopore sequencing from liquid biopsy: analysis of copy number variations from cell-free DNA of lung cancer patients

In the “precision oncology” era the characterization of tumor genetic features is a pivotal step in cancer patients’ management. Liquid biopsy approaches, such as analysis of cell-free DNA from plasma, represe...

Authors: Filippo Martignano, Uday Munagala, Stefania Crucitta, Alessandra Mingrino, Roberto Semeraro, Marzia Del Re, Iacopo Petrini, Alberto Magi and Silvestro G. Conticello

Pan-cancer characterization of expression and clinical relevance of m⁶A-related tissue-elevated long non-coding RNAs

Authors: Kang Xu, Yangyang Cai, Mengying Zhang, Haozhe Zou, Zhenghong Chang, Donghao Li, Jing Bai, Juan Xu and Yongsheng Li

Selective treatment pressure in colon cancer drives the molecular profile of resistant circulating tumor cell clones

The characterization of circulating tumor cells (CTCs) holds promises for precision medicine because these cells are an important clinical indicator of treatment efficacy. We established the first and still on...

Authors: Laure Cayrefourcq, Frédéric Thomas, Thibault Mazard, Eric Assenat, Said Assou and Catherine Alix-Panabières

Cross-talk of four types of RNA modification writers defines tumor microenvironment and pharmacogenomic landscape in colorectal cancer

The four major RNA adenosine modifications, i.e., m⁶A, m¹A, alternative polyadenylation, and adenosine-to-inosine RNA editing, are mediated mostly by the “writer” enzymes and constitute critical mechanisms of epi...

Authors: Huifang Chen, Jiameng Yao, Rujuan Bao, Yu Dong, Ting Zhang, Yanhua Du, Gaoyang Wang, Duan Ni, Zhenzhen Xun, Xiaoyin Niu, Youqiong Ye and Hua-Bing Li

The cancer metabolic reprogramming and immune response

The overlapping metabolic reprogramming of cancer and immune cells is a putative determinant of the antitumor immune response in cancer. Increased evidence suggests that cancer metabolism not only plays a cruc...

Authors: Longzheng Xia, Linda Oyang, Jinguan Lin, Shiming Tan, Yaqian Han, Nayiyuan Wu, Pin Yi, Lu Tang, Qing Pan, Shan Rao, Jiaxin Liang, Yanyan Tang, Min Su, Xia Luo, Yiqing Yang, Yingrui Shi…

Chemotherapeutic and targeted agents can modulate the tumor microenvironment and increase the efficacy of immune checkpoint blockades

The development of immune checkpoint blockade (ICB)-based immunotherapy has dramatically changed methods of cancer treatment. This approach triggers a durable treatment response and prolongs patients' survival...

Authors: Jun-Yan Li, Yu-Pei Chen, Ying-Qin Li, Na Liu and Jun Ma

Comprehensive landscape and future perspectives of circular RNAs in colorectal cancer

Colorectal cancer (CRC) is a common hereditary tumor that is often fatal. Its pathogenesis involves multiple genes, including circular RNAs (circRNAs). Notably, circRNAs constitute a new class of noncoding RNA...

Authors: Fei Long, Zhi Lin, Liang Li, Min Ma, Zhixing Lu, Liang Jing, Xiaorong Li and Changwei Lin