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  1. Content type: Research

    Life of patients with uveal melanoma (UM) is largely threatened by liver metastasis. Little is known about the drivers of liver organotropic metastasis in UM. The elevated activity of transcription of oncogene...

    Authors: Jing Zhang, Shenglan Liu, Qianyun Ye and Jingxuan Pan

    Citation: Molecular Cancer 2019 18:140

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  2. Content type: Review

    Immunotherapy has been incorporated into the first- and second-line treatment strategies for non-small cell lung cancer (NSCLC), profoundly ushering in a new treatment landscape. However, both adaptive signali...

    Authors: Anqi Lin, Ting Wei, Hui Meng, Peng Luo and Jian Zhang

    Citation: Molecular Cancer 2019 18:139

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  3. Content type: Review

    Cancer has become a major health issue worldwide, contributing to a high mortality rate. Tumor metastasis is attributed to the death of most patients. Epithelial-to-mesenchymal transition (EMT) plays a vital r...

    Authors: Bing-Qing Shang, Min-Le Li, Hao-yu Quan, Ping-Fu Hou, Zhong-Wei Li, Su-Fang Chu, Jun-Nian Zheng and Jin Bai

    Citation: Molecular Cancer 2019 18:138

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  4. Content type: Letter to the Editor

    The methylation of N6 adenosine (m6A) plays a critical role in diverse biological processes. However, knowledge regarding the reconstitution of m6A across cancer types is still lacking. Here, we systematically an...

    Authors: Yongsheng Li, Jun Xiao, Jing Bai, Yi Tian, Yinwei Qu, Xiang Chen, Qi Wang, Xinhui Li, Yunpeng Zhang and Juan Xu

    Citation: Molecular Cancer 2019 18:137

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  5. Content type: Research

    Emerging studies suggest that long non-coding RNAs (lncRNAs) play crucial roles in colorectal cancer (CRC). Here, we report a lncRNA, SATB2-AS1, which is specifically expressed in colorectal tissue and is sign...

    Authors: Mu Xu, Xueni Xu, Bei Pan, Xiaoxiang Chen, Kang Lin, Kaixuan Zeng, Xiangxiang Liu, Tao Xu, Li Sun, Jian Qin, Bangshun He, Yuqin Pan, Huiling Sun and Shukui Wang

    Citation: Molecular Cancer 2019 18:135

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  6. Content type: Letter to the Editor

    Emerging evidences demonstrate that circular RNAs (circRNAs) are abnormally expressed in tumors and could serve as prognostic markers for cancers. However, the expression patterns and clinical implications of ...

    Authors: Chengdi Wang, Shuangyan Tan, Wen-Rong Liu, Qian Lei, Wenliang Qiao, Yangping Wu, Xiaoqi Liu, Wei Cheng, Yu-Quan Wei, Yong Peng and Weimin Li

    Citation: Molecular Cancer 2019 18:134

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  7. Content type: Research

    Circular RNAs (circRNAs) represent a subclass of regulatory RNAs that have been shown to have significant regulatory roles in cancer progression. However, the biological functions of circRNAs in bladder cancer...

    Authors: Junming Bi, Hongwei Liu, Wei Dong, Weibin Xie, Qingqing He, Zijian Cai, Jian Huang and Tianxin Lin

    Citation: Molecular Cancer 2019 18:133

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  8. Content type: Review

    Surgical resection is an important avenue for cancer treatment, which, in most cases, can effectively alleviate the patient symptoms. However, accumulating evidence has documented that surgical resection poten...

    Authors: Zhiwei Chen, Peidong Zhang, Ya Xu, Jiahui Yan, Zixuan Liu, Wayne Bond Lau, Bonnie Lau, Ying Li, Xia Zhao, Yuquan Wei and Shengtao Zhou

    Citation: Molecular Cancer 2019 18:132

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  9. Content type: Research

    The RTK/PI3K/AKT pathway plays key roles in the development and progression of many cancers, including GBM. As a regulatory molecule and a potential drug target, the oncogenic role of AKT has been substantiall...

    Authors: Xin Xia, Xixi Li, Fanying Li, Xujia Wu, Maolei Zhang, Huangkai Zhou, Nunu Huang, Xuesong Yang, Feizhe Xiao, Dawei Liu, Lixuan Yang and Nu Zhang

    Citation: Molecular Cancer 2019 18:131

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  10. Content type: Review

    Incidence of hepatocellular carcinoma (HCC) is on the rise due to the prevalence of chronic hepatitis and cirrhosis. Although there are surgical and chemotherapy treatment avenues the mortality rate of HCC rem...

    Authors: Chen Lu, Dawei Rong, Betty Zhang, Wubin Zheng, Xuehao Wang, Ziyi Chen and Weiwei Tang

    Citation: Molecular Cancer 2019 18:130

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  11. Content type: Correction

    Following publication of the original article [1], authors reported Pro. Gang Zhao has to be considered as another corresponding author, according to his important contribution.

    Authors: Chao-Jie Wang, Chun-Chao Zhu, Jia Xu, Ming Wang, Wen-Yi Zhao, Qiang Liu, Gang Zhao and Zi-Zhen Zhang

    Citation: Molecular Cancer 2019 18:129

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    The original article was published in Molecular Cancer 2019 18:115

  12. Content type: Review

    Genetic instability of tumor cells often leads to the occurrence of a large number of mutations, and expression of non-synonymous mutations can produce tumor-specific antigens called neoantigens. Neoantigens a...

    Authors: Miao Peng, Yongzhen Mo, Yian Wang, Pan Wu, Yijie Zhang, Fang Xiong, Can Guo, Xu Wu, Yong Li, Xiaoling Li, Guiyuan Li, Wei Xiong and Zhaoyang Zeng

    Citation: Molecular Cancer 2019 18:128

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  13. Content type: Research

    N6-methyladenosine (m6A) methylation, a well-known modification with new epigenetic functions, has been reported to participate in the tumorigenesis of hepatocellular carcinoma (HCC), providing novel insights ...

    Authors: Yunhao Chen, Chuanhui Peng, Junru Chen, Diyu Chen, Beng Yang, Bin He, Wendi Hu, Yanpeng Zhang, Hua Liu, Longfei Dai, Haiyang Xie, Lin Zhou, Jian Wu and Shusen Zheng

    Citation: Molecular Cancer 2019 18:127

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  14. Content type: Research

    Mounting evidences indicate that circular RNAs (circRNAs) play vital roles in the development and progression of various cancers. However, the detail functions and underlying mechanisms of circRNAs in gastric ...

    Authors: Zhonglin Zhu, Zeyin Rong, Zai Luo, Zhilong Yu, Jing Zhang, Zhengjun Qiu and Chen Huang

    Citation: Molecular Cancer 2019 18:126

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  15. Content type: Review

    Ovarian cancer is one of the most common gynecological malignancies. Upon initial diagnosis, the majority of patients present with widespread metastatic growth within the peritoneal cavity. This metastatic gro...

    Authors: Wenlong Feng, Dylan C. Dean, Francis J. Hornicek, Huirong Shi and Zhenfeng Duan

    Citation: Molecular Cancer 2019 18:124

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  16. Content type: Review

    Piwi interacting RNAs (piRNAs) constitute novel small non-coding RNA molecules of approximately 24–31 nucleotides in length that often bind to members of the piwi protein family to play regulatory roles. Recen...

    Authors: Yongmei Liu, Mei Dou, Xuxia Song, Yanhan Dong, Si Liu, Haoran Liu, Jiaping Tao, Wenjing Li, Xunhua Yin and Wenhua Xu

    Citation: Molecular Cancer 2019 18:123

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  17. Content type: Correction

    After publication of the article [1], the author reported that this article contained some errors.

    Authors: Zhuo-yuan Lin, Guo Chen, Yan-qiong Zhang, Hui-chan He, Yu-xiang Liang, Jian-heng Ye, Ying-ke Liang, Ru-jun Mo, Jian-ming Lu, Yang-jia Zhuo, Yu Zheng, Fu-neng Jiang, Zhao-dong Han, Shu-lin Wu, Wei-de Zhong and Chin-Lee Wu

    Citation: Molecular Cancer 2019 18:122

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    The original article was published in Molecular Cancer 2017 16:48

  18. Content type: Correction

    After publication of the article [1], the author reported that this article contained error. In Funding section, the funding number provided 2016YFC0105100 should have been 2016YFC0105106.

    Authors: Liyuan Fan, Qiang Cao, Jia Liu, Junpeng Zhang and Baosheng Li

    Citation: Molecular Cancer 2019 18:121

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    The original article was published in Molecular Cancer 2019 18:16

  19. Content type: Research

    Bone metastasis (BM) has long been recognized as a major threat to the quality of life of hepatocellular cancer (HCC) patients. While LncRNA34a (Lnc34a) has been shown to regulate colon cancer stem cell asymme...

    Authors: Li Zhang, Hao Niu, Jie Ma, Bao-Ying Yuan, Yu-Han Chen, Yuan Zhuang, Gen-Wen Chen, Zhao-Chong Zeng and Zuo-Lin Xiang

    Citation: Molecular Cancer 2019 18:120

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  20. Content type: Research

    Increasing evidence has revealed a close relationship between non-coding RNAs and cancer progression. Circular RNAs (circRNAs), a recently identified new member of non-coding RNAs, are demonstrated to particip...

    Authors: Liyan Wang, Haiyan Long, Qinghua Zheng, Xiaotong Bo, Xuhua Xiao and Bin Li

    Citation: Molecular Cancer 2019 18:119

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  21. Content type: Retraction Note

    The Editor-in-Chief has retracted this article [1] because Figure 6b overlaps with Figure 8 of [2] and Figure 4a overlaps with Figure 2b of [3]

    Authors: Wenqiao Zang, Yuanyuan Wang, Tao Wang, Yuwen Du, Xiaonan Chen, Min Li and Guoqiang Zhao

    Citation: Molecular Cancer 2019 18:118

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    The original article was published in Molecular Cancer 2015 14:37

  22. Content type: Correction

    After the publication of this work [1], a spelling error was found: the ID of the circRNA, termed circYAP1, in the original publication was misspelled as “has_circ_0002320”.

    Authors: Hui Liu, Yuan Liu, Zhaolian Bian, Jing Zhang, Rui Zhang, Xiaoyu Chen, Yanxia Huang, Yang Wang and Jinshui Zhu

    Citation: Molecular Cancer 2019 18:117

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    The original article was published in Molecular Cancer 2018 17:151

  23. Content type: Review

    Exosomes have emerged as critical mediators of intercellular communication, both locally and systemically, by regulating a diverse range of biological processes between cells. Circular RNA (circRNA) is a novel...

    Authors: Yangxia Wang, Jinbo Liu, Junfen Ma, Ting Sun, Quanbo Zhou, Weiwei Wang, Guixian Wang, Pingjun Wu, Haijiang Wang, Li Jiang, Weitang Yuan, Zhenqiang Sun and Liang Ming

    Citation: Molecular Cancer 2019 18:116

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  24. Content type: Research

    UCA1 is a long non-coding RNA which was found overexpressed in various human cancers including gastric cancer (GC). It is identified that UCA1 promotes GC cells proliferation, migration and invasion, however, ...

    Authors: Chao-Jie Wang, Chun-Chao Zhu, Jia Xu, Ming Wang, Wen-Yi Zhao, Qiang Liu, Gang Zhao and Zi-Zhen Zhang

    Citation: Molecular Cancer 2019 18:115

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    The Correction to this article has been published in Molecular Cancer 2019 18:129

  25. Content type: Research

    Virtually all patients with metastatic prostate cancer (PCa) will relapse and develop lethal castration-resistant prostate cancer (CRPC). Long noncoding RNAs (lncRNAs) are emerging as critical regulatory eleme...

    Authors: Huy Q. Ta, Hilary Whitworth, Yi Yin, Mark Conaway, Henry F. Frierson Jr, Moray J. Campbell, Ganesh V. Raj and Daniel Gioeli

    Citation: Molecular Cancer 2019 18:113

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  26. Content type: Research

    Colorectal carcinoma (CRC) is one of the most common malignant tumors, and its main cause of death is tumor metastasis. RNA N6-methyladenosine (m6A) is an emerging regulatory mechanism for gene expression and met...

    Authors: Ting Li, Pei-Shan Hu, Zhixiang Zuo, Jin-Fei Lin, Xingyang Li, Qi-Nian Wu, Zhan-Hong Chen, Zhao-Lei Zeng, Feng Wang, Jian Zheng, Demeng Chen, Bo Li, Tie-Bang Kang, Dan Xie, Dongxin Lin, Huai-Qiang Ju…

    Citation: Molecular Cancer 2019 18:112

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  27. Content type: Research

    Circular RNAs (circRNAs) are a novel class of endogenous noncoding RNAs formed by a covalently closed loop, and increasing evidence has revealed that circRNAs play crucial functions in regulating gene expressi...

    Authors: Qun Lu, Tianyao Liu, Huijin Feng, Rong Yang, Xiaozhi Zhao, Wei Chen, Bo Jiang, Haixiang Qin, Xu Guo, Minghui Liu, Limin Li and Hongqian Guo

    Citation: Molecular Cancer 2019 18:111

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  28. Content type: Research

    METTL3 is known to be involved in all stages in the life cycle of RNA. It affects the tumor formation by the regulation the m6A modification in the mRNAs of critical oncogenes or tumor suppressors. In bladder ...

    Authors: Jie Han, Jing-zi Wang, Xiao Yang, Hao Yu, Rui Zhou, Hong-Cheng Lu, Wen-Bo Yuan, Jian-chen Lu, Zi-jian Zhou, Qiang Lu, Ji-Fu Wei and Haiwei Yang

    Citation: Molecular Cancer 2019 18:110

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  29. Content type: Research

    Progression to a castration resistance state is the main cause of deaths in prostate cancer (PCa) patients. Androgen Receptor (AR) signaling plays the central role in progression of Castration Resistant Prosta...

    Authors: Peng Gu, Xu Chen, Ruihui Xie, Weibin Xie, Li Huang, Wen Dong, Jinli Han, Xiaodong Liu, Jihong Shen, Jian Huang and Tianxin Lin

    Citation: Molecular Cancer 2019 18:109

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  30. Content type: Research

    Changes in glycogen metabolism is an essential feature among the various metabolic adaptations used by cancer cells to adjust to the conditions imposed by the tumor microenvironment. Our previous study showed ...

    Authors: Lifeng Li, Li Yang, Shiqi Cheng, Zhirui Fan, Zhibo Shen, Wenhua Xue, Yujia Zheng, Feng Li, Dong Wang, Kai Zhang, Jingyao Lian, Dan Wang, Zijia Zhu, Jie Zhao and Yi Zhang

    Citation: Molecular Cancer 2019 18:108

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  31. Content type: Correction

    Following publication of the original article [1], the authors reported that name that appeared in published online version is incorrect. Aifeng Wang should be Aifen Wang. Corrected name is provided in the aut...

    Authors: Yu Yin, Lingfan Xu, Yan Chang, Tao Zeng, Xufeng Chen, Aifen Wang, Jeff Groth, Wen-Chi Foo, Chaozhao Liang, Hailiang Hu and Jiaoti Huang

    Citation: Molecular Cancer 2019 18:107

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    The original article was published in Molecular Cancer 2019 18:11

  32. Content type: Research

    Cancer cells become immortalized through telomere maintenance mechanisms, such as telomerase reverse transcriptase (TERT) activation. In addition to maintaining telomere length, TERT activates manifold cell su...

    Authors: Zhenhua Luo, Weixu Wang, Feng Li, Zhou Songyang, Xuyang Feng, Changchang Xin, Zhiming Dai and Yuanyan Xiong

    Citation: Molecular Cancer 2019 18:106

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  33. Content type: Research

    Recently, the dysregulation of circular RNA (circRNA) have been shown to have important regulatory roles in cancer development and progression, including hepatocellular carcinoma (HCC). However, the roles of m...

    Authors: Peng-Fei Zhang, Chuan-Yuan Wei, Xiao-Yong Huang, Rui Peng, Xuan Yang, Jia-Cheng Lu, Chi Zhang, Chao Gao, Jia-Bin Cai, Ping-Ting Gao, Dong-Mei Gao, Guo-Ming Shi, Ai-Wu Ke and Jia Fan

    Citation: Molecular Cancer 2019 18:105

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  34. Content type: Retraction Note

    The authors have retracted this article [1] because there are errors in Figures 4a and 4b

    Authors: Ze-you Wang, Min Hu, Min-hui Dai, Jing Xiong, Shuai Zhang, Han-jiang Wu, Shan-shan Zhang and Zhao-jian Gong

    Citation: Molecular Cancer 2019 18:104

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    The original article was published in Molecular Cancer 2018 17:3

  35. Content type: Review

    N6-methyladenosine (m6A) is identified as the most common, abundant and conserved internal transcriptional modification, especially within eukaryotic messenger RNAs (mRNAs). M6A modification is installed by the m

    Authors: Xiao-Yu Chen, Jing Zhang and Jin-Shui Zhu

    Citation: Molecular Cancer 2019 18:103

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  36. Content type: Review

    There is growing evidence that regions of the genome that cannot encode proteins play an important role in diseases. These regions are usually transcribed into long non-coding RNAs (lncRNAs). LncRNAs, little o...

    Authors: Lei Zhang, Xiang Meng, Xin-wei Zhu, Deng-cheng Yang, Ran Chen, Yong Jiang and Tao Xu

    Citation: Molecular Cancer 2019 18:102

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  37. Content type: Review

    Autophagy is a highly conserved catabolic process that mediates degradation of pernicious or dysfunctional cellular components, such as invasive pathogens, senescent proteins, and organelles. It can promote or...

    Authors: Hong-Tao Chen, Hao Liu, Min-Jie Mao, Yuan Tan, Xiang-Qiong Mo, Xiao-Jun Meng, Meng-Ting Cao, Chu-Yu Zhong, Yan Liu, Hong Shan and Guan-Min Jiang

    Citation: Molecular Cancer 2019 18:101

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  38. Content type: Review

    Apoptosis resistance is to a large extent a major obstacle leading to chemotherapy failure during cancer treatment. Bypassing the apoptotic pathway to induce cancer cell death is considered to be a promising a...

    Authors: Yitao Gong, Zhiyao Fan, Guopei Luo, Chao Yang, Qiuyi Huang, Kun Fan, He Cheng, Kaizhou Jin, Quanxing Ni, Xianjun Yu and Chen Liu

    Citation: Molecular Cancer 2019 18:100

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  39. Content type: Research

    Our previous report demonstrated that genetic ablation of miR-301a reduces Kras-driven lung tumorigenesis in mice. However, the impact of miR-301a on host anti-tumor immunity remains unexplored. Here we assessed ...

    Authors: Xun Li, Mingtian Zhong, Jiexuan Wang, Lei Wang, Zhanwen Lin, Zhi Cao, Zhujuan Huang, Fengxue Zhang, Yong Li, Ming Liu and Xiaodong Ma

    Citation: Molecular Cancer 2019 18:99

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  40. Content type: Letter to the Editor

    Cancer-associated chromosomal translocations are reported to generate oncogenic circular RNA (circRNA), contributing to tumorigenesis. The fusion gene SLC34A2-ROS1 (solute carrier family 34 member 2 and ROS proto...

    Authors: Ke Wu, Xun Liao, Youling Gong, Juan He, Jian-Kang Zhou, Shuangyan Tan, Wenchen Pu, Canhua Huang, Yu-Quan Wei and Yong Peng

    Citation: Molecular Cancer 2019 18:98

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  41. Content type: Review

    Microbiota is just beginning to be recognized as an important player in carcinogenesis and the interplay among microbes is greater than expected. Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal dise...

    Authors: Miao-Yan Wei, Si Shi, Chen Liang, Qing-Cai Meng, Jie Hua, Yi-Yin Zhang, Jiang Liu, Bo Zhang, Jin Xu and Xian-Jun Yu

    Citation: Molecular Cancer 2019 18:97

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  42. Content type: Research

    The TG-interacting factor 1 (TGIF1) gene, which encodes a nuclear transcriptional corepressor of the TGFβ1/Smad signaling pathway, has been implicated in the pathogenesis of various types of human cancer; howe...

    Authors: Ching-Chieh Weng, Mei-Jen Hsieh, Chia-Chen Wu, Yu-Chun Lin, Yan-Shen Shan, Wen-Chun Hung, Li-Tzong Chen and Kuang-Hung Cheng

    Citation: Molecular Cancer 2019 18:96

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  43. Content type: Research

    Circular RNAs (circRNAs) have been considered to mediate occurrence and development of human cancers, generally acting as microRNA (miRNA) sponges to regulate downstream genes expression. However, the aberrant...

    Authors: Wei Dong, Junming Bi, Hongwei Liu, Dong Yan, Qingqing He, Qianghua Zhou, Qiong Wang, Ruihui Xie, Yinjie Su, Meihua Yang, Tianxin Lin and Jian Huang

    Citation: Molecular Cancer 2019 18:95

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  44. Content type: Research

    Mediator complex subunit 12 (MED12) is an essential hub for transcriptional regulation, in which mutations and overexpression were reported to be associated with several kinds of malignancies. Nevertheless, th...

    Authors: Meng Xu, Fang Wang, Guibo Li, Xiaokun Wang, Xiaona Fang, Haoxuan Jin, Zhen Chen, Jianye Zhang and Liwu Fu

    Citation: Molecular Cancer 2019 18:93

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  45. Content type: Letter to the Editor

    The receptor for hyaluronic acid-mediated motility (RHAMM) is upregulated in various cancers. We previously screened genes upregulated in human hepatocellular carcinomas for their metastatic function in a mous...

    Authors: Soyoung Choi, Dunrui Wang, Xiang Chen, Laura H. Tang, Akanksha Verma, Zhengming Chen, Bu Jung Kim, Leigh Selesner, Kenneth Robzyk, George Zhang, Sharon Pang, Teng Han, Chang S. Chan, Thomas J. Fahey III, Olivier Elemento and Yi-Chieh Nancy Du

    Citation: Molecular Cancer 2019 18:92

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  46. Content type: Research

    Cancer associated fibroblasts (CAFs) are key stroma cells that play dominant roles in tumor progression. However, the CAFs-derived molecular determinants that regulate colorectal cancer (CRC) metastasis and ch...

    Authors: J. L. Hu, W. Wang, X. L. Lan, Z. C. Zeng, Y. S. Liang, Y. R. Yan, F. Y. Song, F. F. Wang, X. H. Zhu, W. J. Liao, W. T. Liao, Y. Q. Ding and L. Liang

    Citation: Molecular Cancer 2019 18:91

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