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  1. Laryngeal squamous cell carcinoma (LSCC) is the second most common malignant tumor in head and neck. Autophagy and circular RNAs (circRNAs) play critical roles in cancer progression and chemoresistance. Howeve...

    Authors: Wei Gao, Huina Guo, Min Niu, Xiwang Zheng, Yuliang Zhang, Xuting Xue, Yunfeng Bo, Xiaoya Guan, Zhongxun Li, Yujia Guo, Long He, Yu Zhang, Li Li, Jimin Cao and Yongyan Wu

    Citation: Molecular Cancer 2020 19:166

    Content type: Research

    Published on:

  2. Circular RNA (circRNAs) and hypoxia have been found to play the key roles in the pathogenesis and progression of cancer including colorectal cancer (CRC). However, the expressions and functions of the specific...

    Authors: Liang-Yan Chen, Lian Wang, Yue-Xiang Ren, Zheng Pang, Yao Liu, Xiao-Dong Sun, Jian Tu, Zheng Zhi, Yan Qin, Li-Na Sun and Jian-Ming Li

    Citation: Molecular Cancer 2020 19:164

    Content type: Research

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  3. Accumulating evidence suggests that the primary and acquired resistance of hepatocellular carcinoma (HCC) to sorafenib is mediated by multiple molecular, cellular, and microenvironmental mechanisms. Understand...

    Authors: Junjie Xu, Zhe Wan, Minyue Tang, Zhongjie Lin, Shi Jiang, Lin Ji, Kirill Gorshkov, Qijiang Mao, Shunjie Xia, Dong Cen, Junhao Zheng, Xiao Liang and Xiujun Cai

    Citation: Molecular Cancer 2020 19:163

    Content type: Research

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  4. Targeting T cell receptor β-chain constant region 1 (TRBC1) CAR-T could specifically kill TRBC1+ T-cell malignancies. However, over-expressed CARs on anti-TRBC1 CAR transduced TRBC1+ T cells (CAR-C1) bound to ...

    Authors: Chaoting Zhang, Heyilimu Palashati, Zhuona Rong, Ningjing Lin, Luyan Shen, Ying Liu, Shance Li, Bentong Yu, Wenjun Yang and Zheming Lu

    Citation: Molecular Cancer 2020 19:162

    Content type: Letter to the Editor

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  5. Trastuzumab resistance in HER2-positive breast cancer is associated with a poorer prognosis. HSP90 is thought to play a major role in such resistance, but N-terminal inhibitors of this target have had little s...

    Authors: Jung Min Park, Yoon-Jae Kim, Soeun Park, Minsu Park, Lee Farrand, Cong-Truong Nguyen, Jihyae Ann, Gibeom Nam, Hyun-Ju Park, Jeewoo Lee, Ji Young Kim and Jae Hong Seo

    Citation: Molecular Cancer 2020 19:161

    Content type: Letter to the Editor

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  6. One unmet challenge in lung cancer diagnosis is to accurately differentiate lung cancer from other lung diseases with similar clinical symptoms and radiological features, such as pulmonary tuberculosis (TB). T...

    Authors: Wanjun Gu, Junchao Shi, Hui Liu, Xudong Zhang, Jin J. Zhou, Musheng Li, Dandan Zhou, Rui Li, Jingzhu Lv, Guoxia Wen, Shanshan Zhu, Ting Qi, Wei Li, Xiaojing Wang, Zhaohua Wang, Hua Zhu…

    Citation: Molecular Cancer 2020 19:159

    Content type: Letter to the Editor

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  7. Emerging evidence has shown that circular RNAs (circRNAs) play a crucial regulatory role in the occurrence and development of cancer. Exploring the roles and mechanisms of circRNAs in tumorigenesis and progres...

    Authors: Cunying Ma, Xiaoying Wang, Fenghua Yang, Yichen Zang, Jiansong Liu, Xinyi Wang, Xia Xu, Wenjuan Li, Jihui Jia and Zhifang Liu

    Citation: Molecular Cancer 2020 19:157

    Content type: Research

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  8. Circular RNAs (circRNAs) are a class of noncoding RNAs (ncRNAs) and can modulate gene expression by binding to miRNAs; further, circRNAs have been shown to participate in several pathological processes. Howeve...

    Authors: Lei Peng, Huaiming Sang, Shuchun Wei, Yuanyuan Li, Duochen Jin, Xudong Zhu, Xuan Li, Yini Dang and Guoxin Zhang

    Citation: Molecular Cancer 2020 19:156

    Content type: Research

    Published on:

  9. Accumulating evidence suggests that dysregulation of transcriptional enhancers plays a significant role in cancer pathogenesis. Herein, we performed a genome-wide discovery of enhancer elements in colorectal c...

    Authors: Kunitoshi Shigeyasu, Shusuke Toden, Tsuyoshi Ozawa, Takatoshi Matsuyama, Takeshi Nagasaka, Toshiaki Ishikawa, Debashis Sahoo, Pradipta Ghosh, Hiroyuki Uetake, Toshiyoshi Fujiwara and Ajay Goel

    Citation: Molecular Cancer 2020 19:155

    Content type: Letter to the Editor

    Published on:

  10. A more common and noninvasive predicting biomarker for programmed cell death 1 (PD-1) antibody remains to be explored. We assessed 46 patients with advanced gastric cancer who received PD-1 antibody immunother...

    Authors: Ying Jin, Dong-Liang Chen, Feng Wang, Chao-pin Yang, Xu-Xian Chen, Jin-qi You, Jin-Sheng Huang, Yang Shao, Dong-Qin Zhu, Yu-Ming Ouyang, Hui-Yan Luo, Zhi-Qiang Wang, Feng-Hua Wang, Yu-Hong Li, Rui-Hua Xu and Dong-Sheng Zhang

    Citation: Molecular Cancer 2020 19:154

    Content type: Letter to the Editor

    Published on:

  11. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Renjie Wang, Sai Zhang, Xuyi Chen, Nan Li, Jianwei Li, Ruichao Jia, Yuanqing Pan and Haiqian Liang

    Citation: Molecular Cancer 2020 19:153

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2018 17:166

  12. N6-methyladenosine (m6A) is the most abundant modification in mRNA of humans. Emerging evidence has supported the fact that m6A is comprehensively involved in various diseases especially cancers. As a crucial rea...

    Authors: Jiangfeng Li, Haiyun Xie, Yufan Ying, Hong Chen, Huaqing Yan, Liujia He, Mingjie Xu, Xin Xu, Zhen Liang, Ben Liu, Xiao Wang, Xiangyi Zheng and Liping Xie

    Citation: Molecular Cancer 2020 19:152

    Content type: Research

    Published on:

  13. Circulating cell-free DNA (cfDNA) analysis is an important tool for cancer monitoring. The patient-specific mutations identified in colorectal cancer (CRC) tissues are usually used to design the cfDNA analysis...

    Authors: Yu-Min Yeh, Peng-Chan Lin, Chung-Ta Lee, Shang-Hung Chen, Bo-Wen Lin, Shao-Chieh Lin, Po-Chuan Chen, Ren-Hao Chan and Meng-Ru Shen

    Citation: Molecular Cancer 2020 19:150

    Content type: Letter to the Editor

    Published on:

  14. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Junming Bi, Hongwei Liu, Wei Dong, Weibin Xie, Qingqing He, Zijian Cai, Jian Huang and Tianxin Lin

    Citation: Molecular Cancer 2020 19:148

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2019 18:133

  15. The highly intra-tumoral heterogeneity and complex cell origination of prostate cancer greatly limits the utility of traditional bulk RNA sequencing in finding better biomarker for disease diagnosis and strati...

    Authors: Xiaoshi Ma, Jinan Guo, Kaisheng Liu, Lipeng Chen, Dale Liu, Shaowei Dong, Jinquan Xia, Qiaoyun Long, Yongjian Yue, Pan Zhao, Fengyan Hu, Zhangang Xiao, Xinghua Pan, Kefeng Xiao, Zhiqiang Cheng, Zunfu Ke…

    Citation: Molecular Cancer 2020 19:147

    Content type: Research

    Published on:

  16. As a point of convergence for numerous oncogenic signaling pathways, signal transducer and activator of transcription 3 (STAT3) is central in regulating the anti-tumor immune response. STAT3 is broadly hyperac...

    Authors: Sailan Zou, Qiyu Tong, Bowen Liu, Wei Huang, Yan Tian and Xianghui Fu

    Citation: Molecular Cancer 2020 19:145

    Content type: Review

    Published on:

  17. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Lu Wang, Guang Yang, Danfeng Zhao, Jiaqi Wang, Yang Bai, Qiang Peng, Hongzhi Wang, Ruizhe Fang, Guang Chen, Zhichao Wang, Keliang Wang, Guangbin Li, Yinhui Yang, Ziqi Wang, Pengyu Guo, Li Peng…

    Citation: Molecular Cancer 2020 19:144

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2019 18:86

  18. Very few proteins encoded by the presumed non-coding RNA transcripts have been identified. Their cellular functions remain largely unknown. This study identifies the tumor-suppressor function of a novel microp...

    Authors: Min Kang, Bo Tang, Jixi Li, Ziyan Zhou, Kang Liu, Rensheng Wang, Ziyan Jiang, Fangfang Bi, David Patrick, Dongin Kim, Anirban K. Mitra and Yang Yang-Hartwich

    Citation: Molecular Cancer 2020 19:143

    Content type: Research

    Published on:

  19. Triple negative breast cancer (TNBC) remains the most challenging breast cancer subtype so far. Specific therapeutic approaches have rarely achieved clinical improvements in treatment of TNBC patients and effe...

    Authors: Jie Li, Maoguang Ma, Xuesong Yang, Maolei Zhang, Jingyan Luo, Huangkai Zhou, Nunu Huang, Feizhe Xiao, Bingquan Lai, Weiming Lv and Nu Zhang

    Citation: Molecular Cancer 2020 19:142

    Content type: Research

    Published on:

  20. Immunotherapy (IO) has revolutionized the therapy landscape of non-small cell lung cancer (NSCLC), significantly prolonging the overall survival (OS) of advanced stage patients. Over the recent years IO therap...

    Authors: Lena Horvath, Bernard Thienpont, Liyun Zhao, Dominik Wolf and Andreas Pircher

    Citation: Molecular Cancer 2020 19:141

    Content type: Review

    Published on:

  21. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Dawei Rong, Chen Lu, Betty Zhang, Kai Fu, Shuli Zhao, Weiwei Tang and Hongyong Cao

    Citation: Molecular Cancer 2020 19:140

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2019 18:25

  22. Human T cell leukemia virus type 1 (HTLV-1)-associated adult T cell leukemia (ATL) has a very poor prognosis with a median survival of 8 months and a 4-year overall survival of 11% for acute ATL. Present treat...

    Authors: Chien-Hung Yeh, Marcia Bellon, Fang Wang, Hong Zhang, Liwu Fu and Christophe Nicot

    Citation: Molecular Cancer 2020 19:139

    Content type: Research

    Published on:

  23. Inactivation of the tumor suppressor p53 is critical for pathogenesis of glioma, in particular glioblastoma multiforme (GBM). MDM2, the main negative regulator of p53, binds to and forms a stable complex with ...

    Authors: Jiacheng Lou, Yuchao Hao, Kefeng Lin, Yizhu Lyu, Meiwei Chen, Han Wang, Deyu Zou, Xuewen Jiang, Renchun Wang, Di Jin, Eric W.-F. Lam, Shujuan Shao, Quentin Liu, Jinsong Yan, Xiang Wang, Puxiang Chen…

    Citation: Molecular Cancer 2020 19:138

    Content type: Research

    Published on:

  24. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jiajie Hou, He Zhang, Jun Liu, Zhenjun Zhao, Jianye Wang, Zhike Lu, Bian Hu, Jiankui Zhou, Zhicong Zhao, Mingxuan Feng, Haiyan Zhang, Bin Shen, Xingxu Huang, Beicheng Sun, Mark J. Smyth, Chuan He…

    Citation: Molecular Cancer 2020 19:137

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2019 18:163

  25. The activation of the cGAS-STING pathway has tremendous potential to improve anti-tumor immunity by generating type I interferons. In recent decades, we have witnessed that producing dsDNA upon various stimuli...

    Authors: Yang Wang, Jingwen Luo, Aqu Alu, Xuejiao Han, Yuquan Wei and Xiawei Wei

    Citation: Molecular Cancer 2020 19:136

    Content type: Review

    Published on:

  26. Cisplatin is a first-line drug for the treatment of human non-small cell lung cancer (NSCLC); however, the majority of patients will develop drug resistance after treatment. In order to overcome cisplatin resi...

    Authors: Wenjing Wang, Mengyue Zhao, Lijuan Cui, Yong Ren, Jingyuan Zhang, Junli Chen, Lina Jia, Jiayu Zhang, Jingyu Yang, Guoliang Chen, Charles R. Ashby Jr, Chunfu Wu, Zhe-Sheng Chen and Lihui Wang

    Citation: Molecular Cancer 2020 19:134

    Content type: Research

    Published on:

  27. Cellular recognition of microbial DNA is an evolutionarily conserved mechanism by which the innate immune system detects pathogens. Cyclic GMP-AMP synthase (cGAS) and its downstream effector, stimulator of int...

    Authors: Juyan Zheng, Junluan Mo, Tao Zhu, Wei Zhuo, Yueneng Yi, Shuo Hu, Jiye Yin, Wei Zhang, Honghao Zhou and Zhaoqian Liu

    Citation: Molecular Cancer 2020 19:133

    Content type: Review

    Published on:

  28. At the moment, pancreatic cancer is among the deadliest gastrointestinal diseases, and pancreatic cancer growth is a complex biological process that is based on different kinds of genes. Exosomes are extracell...

    Authors: Abakundana Nsenga Ariston Gabriel, Fang Wang, Qinlian Jiao, Umwali Yvette, Xuemei Yang, Samed Ahmed Al-Ameri, Lutao Du, Yun-shan Wang and Chuanxin Wang

    Citation: Molecular Cancer 2020 19:132

    Content type: Review

    Published on:

  29. Controlling metastasis is essential for improving the prognosis of patients with gastric cancer (GC). Here, we aimed to identify a molecule required for GC metastasis and to investigate its potential utility a...

    Authors: Mitsuro Kanda, Dai Shimizu, Koichi Sawaki, Shunsuke Nakamura, Shinichi Umeda, Takashi Miwa, Haruyoshi Tanaka, Chie Tanaka, Masamichi Hayashi, Yohei Iguchi, Suguru Yamada, Masahisa Katsuno and Yasuhiro Kodera

    Citation: Molecular Cancer 2020 19:131

    Content type: Research

    Published on:

  30. Pancreatic cancer is one of the most lethal human cancers. N6-methyladenosine (m6A), a common eukaryotic mRNA modification, plays critical roles in both physiological and pathological processes. However, its role...

    Authors: Min Wang, Jun Liu, Yan Zhao, Ruizhi He, Xiaodong Xu, Xingjun Guo, Xu Li, Simiao Xu, Ji Miao, Jianpin Guo, Hang Zhang, Jun Gong, Feng Zhu, Rui Tian, Chengjian Shi, Feng Peng…

    Citation: Molecular Cancer 2020 19:130

    Content type: Research

    Published on:

  31. Heat shock transcription factor1 (HSF1) was overexpressed to promote glutaminolysis and activate mTOR in colorectal cancer (CRC). Here, we investigated the mechanism for cancer-specific overexpression of HSF1.

    Authors: Ping Song, Lifeng Feng, Jiaqiu Li, Dongjun Dai, Liyuan Zhu, Chaoqun Wang, Jingyi Li, Ling Li, Qiyin Zhou, Rongkai Shi, Xian Wang and Hongchuan Jin

    Citation: Molecular Cancer 2020 19:129

    Content type: Research

    Published on:

  32. Deregulated circular RNAs (circRNAs) are associated with the development of cancer and therapy resistance. However, functional research of circRNAs mostly focus on potential miRNA or protein binding and more p...

    Authors: Xiaolong Xu, Jingwei Zhang, Yihao Tian, Yang Gao, Xin Dong, Wenbo Chen, Xiaoning Yuan, Weinan Yin, Jinjing Xu, Ke Chen, Chunjiang He and Lei Wei

    Citation: Molecular Cancer 2020 19:128

    Content type: Research

    Published on:

  33. CircRNAs are a novel class of RNA molecules with a unique closed continuous loop structure. CircRNAs are abundant in eukaryotic cells, have unique stability and tissue specificity, and can play a biological re...

    Authors: Tianwei Xu, Mengwei Wang, Lihua Jiang, Li Ma, Li Wan, Qinnan Chen, Chenchen Wei and Zhaoxia Wang

    Citation: Molecular Cancer 2020 19:127

    Content type: Review

    Published on:

  34. This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.1186/s12943-015-0389-y

    Authors: Paola Bendinelli, Paola Maroni, Emanuela Matteucci and Maria Alfonsina Desiderio

    Citation: Molecular Cancer 2020 19:126

    Content type: Retraction Note

    Published on:

    The original article was published in Molecular Cancer 2015 14:112

  35. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jing Zhang, Lidan Hou, Rui Liang, Xiaoyu Chen, Rui Zhang, Wei Chen and Jinshui Zhu

    Citation: Molecular Cancer 2020 19:125

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2019 18:80

  36. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Hongwei Liu, Junming Bi, Wei Dong, Meihua Yang, Juanyi Shi, Ning Jiang, Tianxin Lin and Jian Huang

    Citation: Molecular Cancer 2020 19:124

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2018 17:161

  37. N6-methyladenosine (m6A) modification is an emerging layer of epigenetic regulation which is widely implicated in the tumorigenicity of hepatocellular carcinoma (HCC), offering a novel perspective for investigati...

    Authors: Yunhao Chen, Yanchun Zhao, Junru Chen, Chuanhui Peng, Yanpeng Zhang, Rongliang Tong, Qiyang Cheng, Beng Yang, Xiaode Feng, Yuejie Lu, Haiyang Xie, Lin Zhou, Jian Wu and Shusen Zheng

    Citation: Molecular Cancer 2020 19:123

    Content type: Research

    Published on:

  38. Super-enhancers (SEs) play a crucial role in cancer, which is often associate with activated oncogenes. However, little is known about how SEs facilitate tumour suppression. Individuals with Down syndrome exhi...

    Authors: Rong Deng, Jun-Hao Huang, Yan Wang, Li-Huan Zhou, Zi-Feng Wang, Bing-Xin Hu, Yu-Hong Chen, Dong Yang, Jia Mai, Zhi-Ling Li, Hai-Liang Zhang, Yun Huang, Xiao-Dan Peng, Gong-Kan Feng, Xiao-Feng Zhu and Jun Tang

    Citation: Molecular Cancer 2020 19:122

    Content type: Research

    Published on:

  39. The tumor microenvironment is highly complex, and immune escape is currently considered an important hallmark of cancer, largely contributing to tumor progression and metastasis. Named for their capability of ...

    Authors: Song-Yang Wu, Tong Fu, Yi-Zhou Jiang and Zhi-Ming Shao

    Citation: Molecular Cancer 2020 19:120

    Content type: Review

    Published on:

  40. Pancreatic cancer is one of the most lethal malignancies and has an extremely poor diagnosis and prognosis. The development of resistance to gemcitabine is still a major challenge. The long noncoding RNA PVT1 ...

    Authors: Cefan Zhou, Changhua Yi, Yongxiang Yi, Wenying Qin, Yanan Yan, Xueying Dong, Xuewen Zhang, Yuan Huang, Rui Zhang, Jie Wei, Declan William Ali, Marek Michalak, Xing-Zhen Chen and Jingfeng Tang

    Citation: Molecular Cancer 2020 19:118

    Content type: Research

    Published on:

  41. Colorectal cancer (CRC) is the leading cause of cancer-related death worldwide. Exosome shave emerged as crucial regulators of intercellular communication and that abundant Circular RNAs (circRNAs) are enriche...

    Authors: Anquan Shang, Chenzheng Gu, Weiwei Wang, Xuan Wang, Junjun Sun, Bingjie Zeng, Chen Chen, Wenjing Chang, Yili Ping, Ping Ji, Junlu Wu, Wenqiang Quan, Yiwen Yao, Yongxin Zhou, Zujun Sun and Dong Li

    Citation: Molecular Cancer 2020 19:117

    Content type: Research

    Published on:

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