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Molecular Cancer

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  1. Content type: Research

    Colorectal cancer (CRC) is a severe health problem worldwide. Clarifying the mechanisms for the deregulation of oncogenes and tumour suppressors in CRC is vital for its diagnosis, treatment, prognosis and prev...

    Authors: Yanqing Liu, Xiaorui Chen, Rongjie Cheng, Fei Yang, Mengchao Yu, Chen Wang, Shufang Cui, Yeting Hong, Hongwei Liang, Minghui Liu, Chihao Zhao, Meng Ding, Wu Sun, Zhijian Liu, Feng Sun, Chenyu Zhang…

    Citation: Molecular Cancer 2018 17:11

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  2. Content type: Research

    Cholangiocarcinoma (CCA) has an abundance of tumor stroma which plays an important role in cancer progression via tumor-promoting signals. This study aims to explore the microRNA (miRNA) profile of CCA-associa...

    Authors: Penkhae Utaijaratrasmi, Kulthida Vaeteewoottacharn, Takaaki Tsunematsu, Pranisa Jamjantra, Sopit Wongkham, Chawalit Pairojkul, Narong Khuntikeo, Naozumi Ishimaru, Yongyut Sirivatanauksorn, Ananya Pongpaibul, Peti Thuwajit, Chanitra Thuwajit and Yasusei Kudo

    Citation: Molecular Cancer 2018 17:10

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  3. Content type: Review

    A vast array of tumor-derived genetic, proteomic and cellular components are constantly released into the circulation of cancer patients. These molecules including circulating tumor DNA and RNA, proteins, tumo...

    Authors: Su Yin Lim, Jenny H. Lee, Russell J. Diefenbach, Richard F. Kefford and Helen Rizos

    Citation: Molecular Cancer 2018 17:8

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  4. Content type: Research

    Most patients with breast cancer in advanced stages of the disease suffer from bone metastases which lead to fractures and nerve compression syndromes. microRNA dysregulation is an important event in the metas...

    Authors: Wei-Luo Cai, Wen-Ding Huang, Bo Li, Tian-Rui Chen, Zhen-Xi Li, Cheng-Long Zhao, Heng-Yu Li, Yan-Mei Wu, Wang-Jun Yan and Jian-Ru Xiao

    Citation: Molecular Cancer 2018 17:9

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  5. Content type: Research

    Long noncoding RNAs (lncRNAs) are an important class of functional regulators involved in human cancers development, including gastric cancer (GC). Studying aberrantly expressed lncRNAs may provide us with new...

    Authors: Jin-Fei Chen, Peng Wu, Rui Xia, Jian Yang, Xin-Ying Huo, Dong-Ying Gu, Cui-Ju Tang, Wei De and Fen Yang

    Citation: Molecular Cancer 2018 17:6

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  6. Content type: Research

    The communication between carcinoma associated fibroblasts (CAFs) and cancer cells facilitate tumor metastasis. In this study, we further underlying the epigenetic mechanisms of CAFs feed the cancer cells and ...

    Authors: Yu Ren, Huan-huan Jia, Yi-qi Xu, Xuan Zhou, Xiao-hui Zhao, Yun-fei Wang, Xin Song, Zhi-yan Zhu, Ting Sun, Yan Dou, Wei-ping Tian, Xiu-lan Zhao, Chun-sheng Kang and Mei Mei

    Citation: Molecular Cancer 2018 17:5

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  7. Content type: Research

    Long non-coding RNA (lncRNA) actin filament associated protein 1 antisense RNA1 (AFAP1-AS1) is oriented in an antisense direction to the protein-coding gene AFAP1 in the opposite strand. Previous studies showed t...

    Authors: Ze-you Wang, Min Hu, Min-hui Dai, Jing Xiong, Shuai Zhang, Han-jiang Wu, Shan-shan Zhang and Zhao-jian Gong

    Citation: Molecular Cancer 2018 17:3

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  8. Content type: Research

    Aberrant activation of the Wnt/β-catenin signaling pathway is frequently observed in colorectal cancer (CRC). β-catenin is the major Wnt signaling pathway effector and inactivation of adenomatous polyposis col...

    Authors: Ying Zhang, Lu Guo, Yuhuan Li, Gui-Hai Feng, Fei Teng, Wei Li and Qi Zhou

    Citation: Molecular Cancer 2018 17:1

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  9. Content type: Review

    Pancreatic cancer is one of the most lethal cancers worldwide due to its insidious symptoms, early metastasis, and chemoresistance. Hence, the underlying mechanisms contributing to pancreatic cancer progressio...

    Authors: Jiangdong Qiu, Gang Yang, Mengyu Feng, Suli Zheng, Zhe Cao, Lei You, Lianfang Zheng, Taiping Zhang and Yupei Zhao

    Citation: Molecular Cancer 2018 17:2

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  10. Content type: Research

    FHIT is a genome caretaker/tumor suppressor that is silenced in >50% of cancers. Although it was identified more than 20 years ago, questions remain as to how FHIT loss contributes to ...

    Authors: Daniel L. Kiss, William Baez, Kay Huebner, Ralf Bundschuh and Daniel R. Schoenberg

    Citation: Molecular Cancer 2017 16:179

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  11. Content type: Research

    Heat shock protein 90 (HSP90) functions as a well-known onco-protein to regulate protein conformation, stability and degradation. Pyruvate kinase M2 (PKM2), a critical regulator of the metabolism, growth and m...

    Authors: Qiuran Xu, Jianfeng Tu, Changwei Dou, Jun Zhang, Liu Yang, Xin Liu, Kefeng Lei, Zhikui Liu, Yufeng Wang, Lijie Li, Hangxing Bao, Jiahui Wang and Kangsheng Tu

    Citation: Molecular Cancer 2017 16:178

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  12. Content type: Letter to the Editor

    Efforts to develop effective cancer therapeutics have been hindered by a lack of clinically predictive preclinical models which recapitulate this complex disease. Patient derived xenograft (PDX) models have em...

    Authors: Alexandra Borodovsky, Travis J. McQuiston, Daniel Stetson, Ambar Ahmed, David Whitston, Jingwen Zhang, Michael Grondine, Deborah Lawson, Sharon S. Challberg, Michael Zinda, Brian A. Pollok, Brian A. Dougherty and Celina M. D’Cruz

    Citation: Molecular Cancer 2017 16:177

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  13. Content type: Review

    Metastasis has intrigued researchers for more than 100 years. Despite the development of technologies and therapeutic strategies, metastasis is still the major cause of cancer-related death until today. The fa...

    Authors: Qiang Liu, Hongfei Zhang, Xiaoli Jiang, Caiyun Qian, Zhuoqi Liu and Daya Luo

    Citation: Molecular Cancer 2017 16:176

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  14. Content type: Research

    Melanoma, originated from melanocytes located on the basal membrane of the epithelial tissue, is the most aggressive form of skin cancer that accounts for 75% of skin cancer-related death. Although it is belie...

    Authors: Xujun Liu, Wenzhe Si, Xinhua Liu, Lin He, Jie Ren, Ziran Yang, Jianguo Yang, Wanjin Li, Shumeng Liu, Fei Pei, Xiaohan Yang and Luyang Sun

    Citation: Molecular Cancer 2017 16:175

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  15. Content type: Research

    Chemoresistance has long been recognized as a major obstacle in cancer therapy. Clarifying the underlying mechanism of chemoresistance would result in novel strategies to improve patient’s response to chemothe...

    Authors: Hu YiRen, Yu YingCong, You Sunwu, Li Keqin, Tong Xiaochun, Chen Senrui, Chen Ende, Lin XiZhou and Chen Yanfan

    Citation: Molecular Cancer 2017 16:174

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  16. Content type: Review

    Exploring gene function is critical for understanding the complexity of life. DNA sequences and the three-dimensional organization of chromatin (chromosomal interactions) are considered enigmatic factors under...

    Authors: Ruobing Jia, Peiwei Chai, He Zhang and Xianqun Fan

    Citation: Molecular Cancer 2017 16:173

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  17. Content type: Research

    Our understanding of the multiple roles exosomes play during tumor progression is still very poor and the contribution of the normal tissue derived exosomes in distant seeding and tumor outgrowth has also not ...

    Authors: Nikolina Dioufa, Amanda M. Clark, Bo Ma, Colin H. Beckwitt and Alan Wells

    Citation: Molecular Cancer 2017 16:172

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  18. Content type: Research

    Accumulating evidence has highlighted the potential role of long non-coding RNAs (lncRNAs) in the biological behaviors of glioblastoma stem cells (GSCs). Here, we elucidated the function and possible molecular...

    Authors: Rui Su, Shuo Cao, Jun Ma, Yunhui Liu, Xiaobai Liu, Jian Zheng, Jiajia Chen, Libo Liu, Heng Cai, Zhen Li, Lini Zhao, Qianru He and Yixue Xue

    Citation: Molecular Cancer 2017 16:171

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  19. Content type: Research

    Lung cancer is the leading cause of cancer death worldwide. However, the molecular mechanisms underlying lung cancer development have not been fully understood. The functions of histone deacetylases (HDACs), a...

    Authors: Yubin Lei, Lingling Liu, Shujing Zhang, Shicheng Guo, Xiaoqing Li, Jiucun Wang, Bo Su, Yuchao Fang, Xiaofeng Chen, Hengning Ke and Wufan Tao

    Citation: Molecular Cancer 2017 16:170

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  20. Content type: Research

    Pancreatic cancer, one of the top two most fatal cancers, is characterized by a desmoplastic reaction that creates a dense microenvironment, promoting hypoxia and inducing the epithelial-to-mesenchymal transit...

    Authors: Hongzhe Li, Xinjing Wang, Chenlei Wen, Zhen Huo, Weishen Wang, Qian Zhan, Dongfeng Cheng, Hao Chen, Xiaxing Deng, Chenghong Peng and Baiyong Shen

    Citation: Molecular Cancer 2017 16:169

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  21. Content type: Letter to the Editor

    Four molecular classifications of pancreatic ductal adenocarcinoma (PDAC), biologically and clinically relevant and based on gene expression profiles, were established in the recent years, including the Collis...

    Authors: David J. Birnbaum, Pascal Finetti, Daniel Birnbaum, Emilie Mamessier and François Bertucci

    Citation: Molecular Cancer 2017 16:168

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  22. Content type: Research

    MicroRNAs (miRNAs) can act as oncogenes or tumor suppressors by controlling cell proliferation, differentiation, metastasis and apoptosis, and miRNA dysregulation is involved in the development of pancreatic c...

    Authors: Manmei Long, Ming Zhan, Sunwang Xu, Ruimeng Yang, Wei Chen, Shilei Zhang, Yongheng Shi, Qiao He, Man Mohan, Qiang Liu and Jian Wang

    Citation: Molecular Cancer 2017 16:167

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  23. Content type: Research

    Accumulating evidence indicates that long non-coding RNAs (lncRNAs) play a crucial role in tumorigenesis. Here, we report a novel lncRNA, RP11-436H11.5, that regulates renal cell carcinoma (RCC) cell prolifera...

    Authors: Kefeng Wang, Wei Jin, Yan Song and Xiang Fei

    Citation: Molecular Cancer 2017 16:166

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