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  1. Emerging studies have revealed the potent functions of circRNAs in breast cancer tumorigenesis. However, the biogenesis, biofunction and mechanism of circRNAs in triple-negative breast cancer (TNBC) are largel...

    Authors: Jie Li, Xinya Gao, Zhanqiang Zhang, Yuanhui Lai, Xunxun Lin, Bo Lin, Maoguang Ma, Xiaoli Liang, Xixi Li, Weiming Lv, Ying Lin and Nu Zhang

    Citation: Molecular Cancer 2021 20:138

    Content type: Research

    Published on:

  2. Authors: Mathias Dahlmann, Guido Gambara, Bernadette Brzezicha, Oliver Popp, Eva Pachmayr, Lena Wedeken, Alina Pflaume, Margarita Mokritzkij, Safak Gül-Klein, Andreas Brandl, Caroline Schweiger-Eisbacher, Philipp Mertins, Jens Hoffmann, Ulrich Keilholz, Wolfgang Walther, Christian Regenbrecht…

    Citation: Molecular Cancer 2021 20:129

    Content type: Letter to the Editor

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  3. Renal Cell Carcinoma (RCC) is difficult to treat with 5-year survival rate of 10% in metastatic patients. Main reasons of therapy failure are lack of validated biomarkers and scarce knowledge of the biological...

    Authors: Lindsay S. Cooley, Justine Rudewicz, Wilfried Souleyreau, Andrea Emanuelli, Arturo Alvarez-Arenas, Kim Clarke, Francesco Falciani, Maeva Dufies, Diether Lambrechts, Elodie Modave, Domitille Chalopin-Fillot, Raphael Pineau, Damien Ambrosetti, Jean-Christophe Bernhard, Alain Ravaud, Sylvie Négrier…

    Citation: Molecular Cancer 2021 20:136

    Content type: Research

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  4. Authors: Atish Kizhakeyil, Nurmahirah Binte Mohammed Zaini, Zhi Sheng Poh, Brandon Han Siang Wong, Xinpeng Loh, Aik Seng Ng, Zun Siong Low, Praseetha Prasannan, Chun Gong, Michelle Guet Khim Tan, Chandramouli Nagarajan, Dachuan Huang, Pang Wan Lu, Jing Quan Lim, Sharon Barrans, Choon Kiat Ong…

    Citation: Molecular Cancer 2021 20:134

    Content type: Letter to the Editor

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  5. AMP-activated protein kinase (AMPK) is a metabolic sensor that maintains energy homeostasis. AMPK functions as a tumor suppressor in different cancers; however, its role in regulating antitumor immunity, parti...

    Authors: Ram Hari Pokhrel, Suman Acharya, Jae-Hee Ahn, Ye Gu, Mahesh Pandit, Jong-Oh Kim, Yun-Yong Park, Ben Kang, Hyun-Jeong Ko and Jae-Hoon Chang

    Citation: Molecular Cancer 2021 20:133

    Content type: Research

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  6. Hepatocellular carcinoma (HCC) is one of the most intractable tumors in the world due to its high rate of recurrence and heterogeneity. Liver cancer initiating cells also called cancer stem cells (CSCs) play a...

    Authors: Yang Gu, Yanying Wang, Luyun He, Jiahang Zhang, Xiaoxiao Zhu, Nian Liu, Jianyi Wang, Tiankun Lu, Lei He, Yong Tian and Zusen Fan

    Citation: Molecular Cancer 2021 20:132

    Content type: Research

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  7. Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin, phenotypic and functional heterogeneity, are the most essential components of the tumor microenvironment (TME). Through mult...

    Authors: Xiaoqi Mao, Jin Xu, Wei Wang, Chen Liang, Jie Hua, Jiang Liu, Bo Zhang, Qingcai Meng, Xianjun Yu and Si Shi

    Citation: Molecular Cancer 2021 20:131

    Content type: Review

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  8. Authors: Odile Berthier-Vergnes, Laetitia Barbollat-Boutrand, Roxane M. Pommier, Arnaud de la Fouchardière, Patrick Combemale, Maxime Grimont, Noémie Lopez-Ramirez, Julie Caramel, Stéphane Dalle, Jean-Luc Perrot, Caroline Gaudy-Marqueste, Nicolas Macagno, Sandrine Mansard, Fanny Bouquet and Ingrid Masse

    Citation: Molecular Cancer 2021 20:127

    Content type: Letter to the Editor

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  9. The 2020 Nobel Prize in Chemistry was awarded to Emmanuelle Charpentier and Jennifer Doudna for the development of the Clustered regularly interspaced short palindromic repeats/CRISPR-associated nuclease9 (CRI...

    Authors: Huimin Zhang, Chunhong Qin, Changming An, Xiwang Zheng, Shuxin Wen, Wenjie Chen, Xianfang Liu, Zhenghua Lv, Pingchang Yang, Wei Xu, Wei Gao and Yongyan Wu

    Citation: Molecular Cancer 2021 20:126

    Content type: Review

    Published on:

  10. In early-stage mycosis fungoides (MF), the most common primary cutaneous T-cell lymphoma, limited skin involvement with patches and plaques is associated with a favorable prognosis. Nevertheless, approximately...

    Authors: Katharina Rindler, Constanze Jonak, Natalia Alkon, Felix M. Thaler, Harald Kurz, Lisa E. Shaw, Georg Stingl, Wolfgang Weninger, Florian Halbritter, Wolfgang M. Bauer, Matthias Farlik and Patrick M. Brunner

    Citation: Molecular Cancer 2021 20:124

    Content type: Research

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  11. Metabolic reprogramming sustains tumorigenesis and aggressiveness of neuroblastoma (NB), the most common extracranial malignancy in childhood, while underlying mechanisms and therapeutic approaches still remai...

    Authors: Feng Yang, Anpei Hu, Yanhua Guo, Jianqun Wang, Dan Li, Xiaojing Wang, Shikai Jin, Boling Yuan, Shuang Cai, Yi Zhou, Qilan Li, Guo Chen, Haiyang Gao, Liduan Zheng and Qiangsong Tong

    Citation: Molecular Cancer 2021 20:123

    Content type: Research

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  12. N6-methyladenosine (m6A) is a prevalent internal modification in eukaryotic RNAs regulated by the so-called “writers”, “erasers”, and “readers”. m6A has been demonstrated to exert critical molecular functions in ...

    Authors: Xin Wang, Rui Ma, Xilin Zhang, Lian Cui, Yangfeng Ding, Weimin Shi, Chunyuan Guo and Yuling Shi

    Citation: Molecular Cancer 2021 20:121

    Content type: Review

    Published on:

  13. Cancer cells develop resistance to chemotherapeutic intervention by excessive formation of stress granules (SGs), which are modulated by an oncogenic protein G3BP2. Selective control of G3BP2/SG signaling is a...

    Authors: Haichang Li, Pei-Hui Lin, Pranav Gupta, Xiangguang Li, Serena Li Zhao, Xinyu Zhou, Zhongguang Li, Shengcai Wei, Li Xu, Renzhi Han, Jing Lu, Tao Tan, Dong-Hua Yang, Zhe-Sheng Chen, Timothy M. Pawlik, Robert E. Merritt…

    Citation: Molecular Cancer 2021 20:118

    Content type: Research

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  14. Adenosine deaminases acting on RNA (ADARs) modify many cellular RNAs by catalyzing the conversion of adenosine to inosine (A-to-I), and their deregulation is associated with several cancers. We recently showed...

    Authors: Julia Ramírez-Moya, Christos Miliotis, Allison R. Baker, Richard I. Gregory, Frank J. Slack and Pilar Santisteban

    Citation: Molecular Cancer 2021 20:115

    Content type: Research

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  15. Circular RNAs (circRNAs) play important roles in cancer progression and metabolism regulation. Serine/glycine metabolism supports the growth of cancer cells by contributing to their anabolic demands and epigen...

    Authors: Xin Liu, Yunze Liu, Zhao Liu, Changwei Lin, Fanchao Meng, Lei Xu, Xiuzhong Zhang, Chong Zhang, Penbo Zhang, Shuai Gong, Nai Wu, Zeqiang Ren, Jun Song and Yi Zhang

    Citation: Molecular Cancer 2021 20:114

    Content type: Research

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  16. Extrachromosomal circular DNA (eccDNA) refers to a type of circular DNA that originate from but are likely independent of chromosomes. Due to technological advancements, eccDNAs have recently emerged as multif...

    Authors: Xiaoxuan Ling, Yali Han, Jinxue Meng, Bohuan Zhong, Jialong Chen, He Zhang, Jiheng Qin, Jing Pang and Linhua Liu

    Citation: Molecular Cancer 2021 20:113

    Content type: Review

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  17. Circular RNAs (circRNAs) are widely expressed in human cells and are closely associated with cancer development. However, they have rarely been investigated in the context of nasopharyngeal carcinoma (NPC).

    Authors: Yongzhen Mo, Yumin Wang, Shuai Zhang, Fang Xiong, Qijia Yan, Xianjie Jiang, Xiangying Deng, Yian Wang, Chunmei Fan, Le Tang, Shanshan Zhang, Zhaojian Gong, Fuyan Wang, Qianjin Liao, Can Guo, Yong Li…

    Citation: Molecular Cancer 2021 20:112

    Content type: Research

    Published on:

  18. Synthetic lethality describes a genetic interaction between two perturbations, leading to cell death, whereas neither event alone has a significant effect on cell viability. This concept can be exploited to sp...

    Authors: Salvatore Benfatto, Özdemirhan Serçin, Francesca R. Dejure, Amir Abdollahi, Frank T. Zenke and Balca R. Mardin

    Citation: Molecular Cancer 2021 20:111

    Content type: Research

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  19. Authors: Yun-ping Hu, Yun-peng Jin, Xiang-song Wu, Yang Yang, Yong-sheng Li, Huai-feng Li, Shan-shan Xiang, Xiao-ling Song, Lin Jiang, Yi-jian Zhang, Wen Huang, Shi-li Chen, Fa-tao Liu, Chen Chen, Qin Zhu, Hong-zhuan Chen…

    Citation: Molecular Cancer 2021 20:110

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2019 18:167

  20. Early recurrence is a major obstacle to prolonged postoperative survival in squamous cell lung carcinoma (SqCLC). The molecular mechanisms underlying early SqCLC recurrence remain unclear, and effective progno...

    Authors: Qingqing Wu, Xiaoyang Luo, Mikkel G. Terp, Qingrun Li, Yuan Li, Lei Shen, Ying Chen, Kirstine Jacobsen, Trever G. Bivona, Haiquan Chen, Rong Zeng and Henrik J. Ditzel

    Citation: Molecular Cancer 2021 20:108

    Content type: Research

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  21. Necroptosis is emerging as a new target for cancer immunotherapy as it is now recognized as a form of cell death that increases tumor immunogenicity, which would be especially helpful in treating immune-desert...

    Authors: Han-Hee Park, Hwa-Ryeon Kim, Sang-Yeong Park, Sung-Min Hwang, Sun Mi Hong, Sangwook Park, Ho Chul Kang, Michael J. Morgan, Jong-Ho Cha, Dakeun Lee, Jae-Seok Roe and You-Sun Kim

    Citation: Molecular Cancer 2021 20:107

    Content type: Research

    Published on:

  22. Extensive studies have demonstrated the pivotal roles of circular RNAs (circRNAs) in the occurrence and development of different human cancers. However, the expression and regulatory roles of circRNAs in pancr...

    Authors: Zeyin Rong, Si Shi, Zhen Tan, Jin Xu, Qingcai Meng, Jie Hua, Jiang Liu, Bo Zhang, Wei Wang, Xianjun Yu and Chen Liang

    Citation: Molecular Cancer 2021 20:106

    Content type: Research

    Published on:

  23. An in-depth understanding of immune evasion mechanisms in tumors is crucial to overcome resistance and enable innovative advances in immunotherapy. Circular RNAs (circRNAs) have been implicated in cancer progr...

    Authors: Zhenchuan Liu, Tingting Wang, Yunlang She, Kaiqing Wu, Shaorui Gu, Lei Li, Chenglai Dong, Chang Chen and Yongxin Zhou

    Citation: Molecular Cancer 2021 20:105

    Content type: Research

    Published on:

  24. Constitutive activation of nuclear factor-κB (NF-κB) signaling plays a key role in the development and progression of colorectal carcinoma (CRC). However, the underlying mechanisms of excessive activation of N...

    Authors: Zhen-xing Liang, Hua-shan Liu, Li Xiong, Xin Yang, Feng-wei Wang, Zi-wei Zeng, Xiao-wen He, Xian-rui Wu and Ping Lan

    Citation: Molecular Cancer 2021 20:103

    Content type: Research

    Published on:

  25. Authors: Tao Zhang, Rong Qu, Shingpan Chan, Mengzhen Lai, Linjiang Tong, Fang Feng, Hongyu Chen, Tingting Song, Peiran Song, Gang Bai, Yingqiang Liu, Yanan Wang, Yan Li, Yi Su, Yanyan Shen, Yiming Sun…

    Citation: Molecular Cancer 2021 20:102

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2020 19:90

  26. Circular RNAs (circRNAs) play important roles in cancer development and progression. The purpose of this study is to identify aberrantly expressed circRNAs in gastric cancer (GC), unravel their roles in GC pro...

    Authors: Yu Zhang, Jiajia Jiang, Jiayin Zhang, Han Shen, Maoye Wang, Zhen Guo, Xueyan Zang, Hui Shi, Jiayan Gao, Hui Cai, Xinjian Fang, Hui Qian, Wenrong Xu and Xu Zhang

    Citation: Molecular Cancer 2021 20:101

    Content type: Research

    Published on:

  27. 3-phosphoinositide-dependent protein kinase-1 (PDK1) acts as a master kinase of protein kinase A, G, and C family (AGC) kinase to predominantly govern cell survival, proliferation, and metabolic homeostasis. A...

    Authors: Qiwei Jiang, Nana Zheng, Lang Bu, Xiaomei Zhang, Xiaoling Zhang, Yuanzhong Wu, Yaqing Su, Lei Wang, Xiaomin Zhang, Shancheng Ren, Xiangpeng Dai, Depei Wu, Wei Xie, Wenyi Wei, Yasheng Zhu and Jianping Guo

    Citation: Molecular Cancer 2021 20:100

    Content type: Research

    Published on:

  28. Exosomes are a subpopulation of the tumour microenvironment (TME) that transmit various biological molecules to promote intercellular communication. Exosomes are derived from nearly all types of cells and exis...

    Authors: Xiao-Huan Tang, Ting Guo, Xiang-Yu Gao, Xiao-Long Wu, Xiao-Fang Xing, Jia-Fu Ji and Zi-Yu Li

    Citation: Molecular Cancer 2021 20:99

    Content type: Review

    Published on:

  29. Breast cancer (BC) has a marked tendency to spread to the bone, resulting in significant skeletal complications and mortality. Recently, circular RNAs (circRNAs) have been reported to contribute to cancer init...

    Authors: Yingru Xu, Shuxia Zhang, Xinyi Liao, Man Li, Suwen Chen, Xincheng Li, Xingui Wu, Meisongzhu Yang, Miaoling Tang, Yameng Hu, Ziwen Li, Ruyuan Yu, Mudan Huang, Libing Song and Jun Li

    Citation: Molecular Cancer 2021 20:98

    Content type: Research

    Published on:

  30. Authors: Shunya Ohmura, Aruna Marchetto, Martin F. Orth, Jing Li, Susanne Jabar, Andreas Ranft, Endrit Vinca, Katharina Ceranski, Martha J. Carreño-Gonzalez, Laura Romero-Pérez, Fabienne S. Wehweck, Julian Musa, Felix Bestvater, Maximilian M. L. Knott, Tilman L. B. Hölting, Wolfgang Hartmann…

    Citation: Molecular Cancer 2021 20:97

    Content type: Letter to the Editor

    Published on:

  31. The aim of this study was to identify a urine extracellular vesicle circular RNA (circRNA) classifier that could detect high-grade prostate cancer (PCa) of Grade Group (GG) 2 or greater. For this purpose, we u...

    Authors: Ya-Di He, Wen Tao, Tao He, Bang-Yu Wang, Xiu-Mei Tang, Liang-Ming Zhang, Zhen-Quan Wu, Wei-Ming Deng, Ling-Xiao Zhang, Chun-Kui Shao, Jing Zhou, Li-Min Rong, Xin Gao and Liao-Yuan Li

    Citation: Molecular Cancer 2021 20:96

    Content type: Letter to the Editor

    Published on:

  32. Colorectal cancer (CRC) is one of the most common malignant tumours. The recurrence and metastasis of CRC seriously affect the survival rate of patients. Angiogenesis is an extremely important cause of tumour ...

    Authors: Yaxin Guo, Yuying Guo, Chen Chen, Dandan Fan, Xiaoke Wu, Luyang Zhao, Bo Shao, Zhenqiang Sun and Zhenyu Ji

    Citation: Molecular Cancer 2021 20:93

    Content type: Research

    Published on:

  33. Cancer metastases are the main cause of lethality. The five-year survival rate for patients diagnosed with advanced stage oral cancer is 30%. Hence, the identification of novel therapeutic targets is an urgent...

    Authors: Jonas Weiße, Julia Rosemann, Lisa Müller, Matthias Kappler, Alexander W. Eckert, Markus Glaß, Danny Misiak, Stefan Hüttelmaier, Wolfgang G. Ballhausen, Mechthild Hatzfeld, Monika Haemmerle and Tony Gutschner

    Citation: Molecular Cancer 2021 20:88

    Content type: Research

    Published on:

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