Skip to main content

Articles

Page 1 of 57

  1. Cancer is a type of malignant affliction threatening human health worldwide; however, the molecular mechanism of cancer pathogenesis remains to be elusive. The oncogenic hedgehog (Hh) pathway is a highly evolu...

    Authors: Jia Song, Yuexin Ge, Xiaoyu Sun, Qiutong Guan, Shiqiang Gong, Minjie Wei, Jumin Niu and Lin Zhao
    Citation: Molecular Cancer 2022 21:115
  2. Ovarian cancer (OC) is the most lethal gynecologic malignancy worldwide. One of the main challenges in the management of OC is the late clinical presentation of disease that results in poor survival. Conventio...

    Authors: Jie Wei Zhu, Parsa Charkhchi and Mohammad R. Akbari
    Citation: Molecular Cancer 2022 21:114
  3. Brain metastasis (BrM) is a major problem associated with cancer-related mortality, and currently, no specific biomarkers are available in clinical settings for early detection. Liquid biopsy is widely accepte...

    Authors: Asad Ur Rehman, Parvez Khan, Shailendra Kumar Maurya, Jawed A. Siddiqui, Juan A. Santamaria-Barria, Surinder K. Batra and Mohd Wasim Nasser
    Citation: Molecular Cancer 2022 21:113
  4. Although gemcitabine has been considered as the first-line drug for advanced pancreatic cancer (PC), development of resistance to gemcitabine severely limits the effectiveness of this chemotherapy, and the und...

    Authors: Jianyou Gu, Wenjie Huang, Xianxing Wang, Junfeng Zhang, Tian Tao, Yao Zheng, Songsong Liu, Jiali Yang, Zhe-Sheng Chen, Chao-Yun Cai, Jinsui Li, Huaizhi Wang and Yingfang Fan
    Citation: Molecular Cancer 2022 21:112
  5. Sunitinib resistance can be classified into primary and secondary resistance. While accumulating research has indicated several underlying factors contributing to sunitinib resistance, the precise mechanisms i...

    Authors: Yuanlei Chen, Zeyi Lu, Chao Qi, Chenhao Yu, Yang Li, Wang Huan, Ruyue Wang, Wenqin Luo, Danyang Shen, Lifeng Ding, Liangliang Ren, Haiyun Xie, Dingwei Xue, Mingchao Wang, Kangxin Ni, Liqun Xia…
    Citation: Molecular Cancer 2022 21:111
  6. Previous studies have confirmed the oncogenic role of HMGB2 in various cancers, but the biological functions of HMGB2-derived circRNAs remain unknown. Thus, we intended to investigate the potential role of HMG...

    Authors: Ling-Xian Zhang, Jian Gao, Xiang Long, Peng-Fei Zhang, Xin Yang, Shu-Qiang Zhu, Xu Pei, Bai-Quan Qiu, Shi-Wei Chen, Feng Lu, Kun Lin, Jian Jun Xu and Yong-Bing Wu
    Citation: Molecular Cancer 2022 21:110
  7. Emerging evidence suggest the critical role of circular RNAs (circRNAs) in disease development especially in various cancers. However, the oncogenic role of circRNAs in hepatocellular carcinoma (HCC) is still ...

    Authors: Ashuai Du, Shiqin Li, Yuzheng Zhou, Cyrollah Disoma, Yujie Liao, Yongxing Zhang, Zongpeng Chen, Qinglong Yang, Pinjia Liu, Sixu Liu, Zijun Dong, Aroona Razzaq, Siyi Tao, Xuan Chen, Yuxin Liu, Lunan Xu…
    Citation: Molecular Cancer 2022 21:109
  8. CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt pathway. Aberrant Wnt pathway activation...

    Authors: Chen Xue, Ganglei Li, Qiuxian Zheng, Xinyu Gu, Zhengyi Bao, Juan Lu and Lanjuan Li
    Citation: Molecular Cancer 2022 21:108
  9. Lung cancer is a kind of malignancy with high morbidity and mortality worldwide. Paclitaxel (PTX) is the main treatment for non-small cell lung cancer (NSCLC), and resistance to PTX seriously affects the survi...

    Authors: Wenjing Wang, Jianmin Wang, Shuai Liu, Yong Ren, Jingyu Wang, Sen Liu, Wei Cui, Lina Jia, Xing Tang, Jingyu Yang, Chunfu Wu and Lihui Wang
    Citation: Molecular Cancer 2022 21:106
  10. Long non-coding RNAs (lncRNAs) have been demonstrated to play vital roles in cancer development and progression. However, their biological roles and function mechanisms in liver cancer remain largely unknown.

    Authors: Kefei Yuan, Jiang Lan, Lin Xu, Xuping Feng, Haotian Liao, Kunlin Xie, Hong Wu and Yong Zeng
    Citation: Molecular Cancer 2022 21:105
  11. Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1/P-gp) is a major cause of cancer chemotherapy failure, but the regulation mechanisms are largely unknown.

    Authors: Lei Zhang, Yidong Li, Chaohua Hu, Yangmin Chen, Zhuo Chen, Zhe-Sheng Chen, Jian-Ye Zhang and Shuo Fang
    Citation: Molecular Cancer 2022 21:103
  12. Redirecting pre-existing virus-specific cytotoxic CD8+ T lymphocytes (CTLs) to tumors by simulating a viral infection of the tumor cells has great potential for cancer immunotherapy. However, this strategy is lim...

    Authors: Keunok Jung, Min-Jeong Son, Se-Young Lee, Jeong-Ah Kim, Deok-Han Ko, Sojung Yoo, Chul-Ho Kim and Yong-Sung Kim
    Citation: Molecular Cancer 2022 21:102
  13. Authors: Changwei Lin, Min Ma, Yi Zhang, Liang Li, Fei Long, Canbin Xie, Hua Xiao, Teng Liu, Buning Tian, Kaiyan Yang, Yihang Guo, Miao Chen, Jin Chou, Ni Gong, Xiaorong Li and Gui Hu
    Citation: Molecular Cancer 2022 21:101

    The original article was published in Molecular Cancer 2022 21:80

  14. Proteolysis-targeting chimeras (PROTACs) are engineered techniques for targeted protein degradation. A bifunctional PROTAC molecule with two covalently-linked ligands recruits target protein and E3 ubiquitin l...

    Authors: Xinyi Li, Wenchen Pu, Qingquan Zheng, Min Ai, Song Chen and Yong Peng
    Citation: Molecular Cancer 2022 21:99
  15. The tumor microenvironment (TME) is essential for immune escape by tumor cells. It plays essential roles in tumor development and metastasis. The clinical outcomes of tumors are often closely related to indivi...

    Authors: Ke Liu, Jia-Jia Cui, Yan Zhan, Qian-Ying Ouyang, Qi-Si Lu, Dong-Hua Yang, Xiang-Ping Li and Ji-Ye Yin
    Citation: Molecular Cancer 2022 21:98
  16. N6-methyladenosine (m6A) RNA modification plays a critical role in various physiological and pathological conditions. However, the role of m6A modification in head and neck squamous cell carcinoma (HNSCC) rema...

    Authors: Shufang Jin, Mingyu Li, Hanyue Chang, Ruijie Wang, Zhiyuan Zhang, Jianjun Zhang, Yue He and Hailong Ma
    Citation: Molecular Cancer 2022 21:97
  17. Breast cancer continues to be a major global problem with significant mortality associated with advanced stage and metastases at clinical presentation. However, several findings suggest that metastasis is inde...

    Authors: Vinitha Richard, Matthew G. Davey, Heidi Annuk, Nicola Miller and Michael J. Kerin
    Citation: Molecular Cancer 2022 21:95
  18. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12943-015-0465-3.

    Authors: Peng Yang, Fang Ni, Rui-qing Deng, Guo Qiang, Hua Zhao, Ming-zhen Yang, Xin-yi Wang, You-zhi Xu, Li Chen, Dan-lei Chen, Zhi-jun Chen, Li-xin Kan and Si-Ying Wang
    Citation: Molecular Cancer 2022 21:94
  19. Circular RNAs (circRNAs) regulate various biological activities and have been shown to play crucial roles in hepatocellular carcinoma (HCC) progression. However, only a few coding circRNAs have been identified...

    Authors: Jin-Ling Duan, Wei Chen, Juan-Juan Xie, Mao-Lei Zhang, Run-Cong Nie, Hu Liang, Jie Mei, Kai Han, Zhi-Cheng Xiang, Feng-Wei Wang, Kai Teng, Ri-Xin Chen, Min-Hua Deng, Yi-Xin Yin, Nu Zhang, Dan Xie…
    Citation: Molecular Cancer 2022 21:93
  20. Circular RNAs (circRNAs) are involved in regulatory processes of ubiquitination and deubiquitination in various tumors at post-transcriptional epigenetic modification level. However, the underlying mechanism a...

    Authors: Zheng Wang, Anqi Sun, Aihui Yan, Jian Yao, Haibo Huang, Ziming Gao, Tao Han, Jia Gu, Ni Li, Huizhe Wu and Kai Li
    Citation: Molecular Cancer 2022 21:92
  21. Authors: Kuailu Lin, Franziska Baenke, Xixi Lai, Martin Schneider, Dominic Helm, Heike Polster, Venkatesh S. Rao, Nicole Ganig, Fang Cheng Wong, Lena Seifert, Adrian M. Seifert, Beatrix Jahnke, Nicole Kretschmann, Tjalf Ziemssen, Fee Klupp, Thomas Schmidt…
    Citation: Molecular Cancer 2022 21:91
  22. Authors: Chunling Ma, Fang Wang, Bing Han, Xiaoli Zhong, Fusheng Si, Jian Ye, Eddy C. Hsueh, Lynn Robbins, Susan M. Kiefer, Yanping Zhang, Pamela Hunborg, Mark A. Varvares, Michael Rauchman and Guangyong Peng
    Citation: Molecular Cancer 2022 21:90

    The original article was published in Molecular Cancer 2018 17:78

  23. Frequent truncation mutations of the histone lysine N-methyltransferase KMT2C have been detected by whole exome sequencing studies in various cancers, including malignancies of the prostate. However, the biologic...

    Authors: Tanja Limberger, Michaela Schlederer, Karolina Trachtová, Ines Garces de los Fayos Alonso, Jiaye Yang, Sandra Högler, Christina Sternberg, Vojtech Bystry, Jan Oppelt, Boris Tichý, Margit Schmeidl, Petra Kodajova, Anton Jäger, Heidi A. Neubauer, Monika Oberhuber, Belinda S. Schmalzbauer…
    Citation: Molecular Cancer 2022 21:89
  24. Hypoxia has long been considered as a hallmark of solid tumors and is closely associated with tumor progression. Circular RNAs (circRNAs) have been identified as a critical modulator in various cancers. Howeve...

    Authors: Rui Yang, Hang Chen, Lei Xing, Bin Wang, Mengting Hu, Xiaoqiang Ou, Hong Chen, Yumei Deng, Dawei Liu, Rong Jiang and Junxia Chen
    Citation: Molecular Cancer 2022 21:88
  25. FBXW7 (F-Box and WD Repeat Domain Containing 7) (also referred to as FBW7 or hCDC4) is a component of the Skp1-Cdc53 / Cullin-F-box-protein complex (SCF/β-TrCP). As a member of the F-box protein family, FBXW7 ...

    Authors: Jingyi Fan, Marcia Bellon, Mingyi Ju, Lin Zhao, Minjie Wei, Liwu Fu and Christophe Nicot
    Citation: Molecular Cancer 2022 21:87
  26. Colorectal cancer (CRC) is one of the most common cancers worldwide and a leading cause of carcinogenic death. To date, surgical resection is regarded as the gold standard by the operator for clinical decision...

    Authors: Hui Zhou, Liyong Zhu, Jun Song, Guohui Wang, Pengzhou Li, Weizheng Li, Ping Luo, Xulong Sun, Jin Wu, Yunze Liu, Shaihong Zhu and Yi Zhang
    Citation: Molecular Cancer 2022 21:86
  27. Immune checkpoint inhibitors had a great effect in triple-negative breast cancer (TNBC); however, they benefited only a subset of patients, underscoring the need to co-target alternative pathways and select op...

    Authors: Song-Yang Wu, Ying Xu, Li Chen, Lei Fan, Xiao-Yan Ma, Shen Zhao, Xiao-Qing Song, Xin Hu, Wen-Tao Yang, Wen-Jun Chai, Xiao-Mao Guo, Xi-Zi Chen, Yan-Hui Xu, Xiao-Yu Zhu, Jian-Jun Zou, Zhong-Hua Wang…
    Citation: Molecular Cancer 2022 21:84
  28. Cancer is caused by a combination of genetic and epigenetic abnormalities. Current cancer therapies are limited due to the complexity of their mechanism, underlining the need for alternative therapeutic approa...

    Authors: Sushmaa Chandralekha Selvakumar, K. Auxzilia Preethi, Kehinde Ross, Deusdedit Tusubira, Mohd Wajid Ali Khan, Panagal Mani, Tentu Nageswara Rao and Durairaj Sekar
    Citation: Molecular Cancer 2022 21:83
  29. miR-346 was identified as an activator of Androgen Receptor (AR) signalling that associates with DNA damage response (DDR)-linked transcripts in prostate cancer (PC). We sought to delineate the impact of miR-3...

    Authors: C. E. Fletcher, L. Deng, F. Orafidiya, W. Yuan, M. P. G. S. Lorentzen, O. W. Cyran, A. Varela-Carver, T. A. Constantin, D. A. Leach, F. M. Dobbs, I. Figueiredo, B. Gurel, E. Parkes, D. Bogdan, R. R. Pereira, S. G. Zhao…
    Citation: Molecular Cancer 2022 21:82
  30. Previous studies have shown that the N6-methyladenosine (m6A) modification enhances the binding ability of mRNAs/long noncoding RNAs (lncRNAs) to microRNAs (miRNAs), but the impact of this modification on the com...

    Authors: Changwei Lin, Min Ma, Yi Zhang, Liang Li, Fei Long, Canbin Xie, Hua Xiao, Teng Liu, Buning Tian, Kaiyan Yang, Yihang Guo, Miao Chen, Jin Chou, Ni Gong, Xiaorong Li and Gui Hu
    Citation: Molecular Cancer 2022 21:80

    The Correction to this article has been published in Molecular Cancer 2022 21:101

  31. Over the past decade, invasive techniques for diagnosing and monitoring cancers are slowly being replaced by non-invasive methods such as liquid biopsy. Liquid biopsies have drastically revolutionized the fiel...

    Authors: Saife N. Lone, Sabah Nisar, Tariq Masoodi, Mayank Singh, Arshi Rizwan, Sheema Hashem, Wael El-Rifai, Davide Bedognetti, Surinder K. Batra, Mohammad Haris, Ajaz A. Bhat and Muzafar A. Macha
    Citation: Molecular Cancer 2022 21:79
  32. The use of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) brings remarkable benefits for the survival of patients with advanced NSCLC harboring EGFR mutations. Unfortunately, acquired ...

    Authors: Zhenzhen Pan, Kai Wang, Xiniao Wang, Zhirong Jia, Yuqi Yang, Yalei Duan, Lianzhan Huang, Zhuo-Xun Wu, Jian-ye Zhang and Xuansheng Ding
    Citation: Molecular Cancer 2022 21:77
  33. N6-methyladenosine (m6A) is the most abundant epigenetic modification of RNA, and its dysregulation drives aberrant transcription and translation programs that promote cancer occurrence and progression. Although ...

    Authors: Xinxin Li, Shoubao Ma, Youcai Deng, Ping Yi and Jianhua Yu
    Citation: Molecular Cancer 2022 21:76
  34. Histone lysine-specific demethylase 1 (LSD1) expression has been shown to be significantly elevated in gastric cancer (GC) and may be associated with the proliferation and metastasis of GC. It has been reporte...

    Authors: Dan-Dan Shen, Jing-Ru Pang, Ya-Ping Bi, Long-Fei Zhao, Yin-Rui Li, Li-Juan Zhao, Ya Gao, Bo Wang, Ning Wang, Liuya Wei, Huiqin Guo, Hong-Min Liu and Yi-Chao Zheng
    Citation: Molecular Cancer 2022 21:75
  35. Epithelial-to-mesenchymal transition (EMT) is a process linked to metastasis and drug resistance with non-coding RNAs (ncRNAs) playing pivotal roles. We previously showed that miR-100 and miR-125b, embedded wi...

    Authors: Hao Liu, Danxiu Li, Lina Sun, Hongqiang Qin, Ahui Fan, Lingnan Meng, Ramona Graves-Deal, Sarah E. Glass, Jeffrey L. Franklin, Qi Liu, Jing Wang, Timothy J. Yeatman, Hao Guo, Hong Zong, Shuilin Jin, Zhiyu Chen…
    Citation: Molecular Cancer 2022 21:74
  36. Circulating tumor cells (CTCs) are liquid biopsies that represent micrometastatic disease and may offer unique insights into future recurrences in non-small cell lung cancer (NSCLC). Due to CTC rarity and limi...

    Authors: Kanve N. Suvilesh, Yulia I. Nussbaum, Vijay Radhakrishnan, Yariswamy Manjunath, Diego M. Avella, Kevin F. Staveley-O’Carroll, Eric T. Kimchi, Aadel A. Chaudhuri, Chi-Ren Shyu, Guangfu Li, Klaus Pantel, Wesley C. Warren, Jonathan B. Mitchem and Jussuf T. Kaifi
    Citation: Molecular Cancer 2022 21:73
  37. Although the prognostic outcomes of liver cancer (LC) cases have improved with the advancement in diagnostic technology and treatment methods, the transferability and recurrence of HCC and the 5-year and 10-ye...

    Authors: Weiwei Liu, Lu zheng, Rongguiyi Zhang, Ping Hou, Jiakun Wang, Linquan Wu and Jing Li
    Citation: Molecular Cancer 2022 21:72
  38. Pancreatic cancer is one of the most lethal cancers worldwide. The IAPs function as E3 ubiquitin ligases and contribute to pancreatic cancer initiation, progression, and metastasis. Although IAP-targeted thera...

    Authors: Simin Qi, Xiaoqing Guan, Jia Zhang, Dehua Yu, Xuefei Yu, Qinglin Li, Wenjuan Yin, Xiang-Dong Cheng, Weidong Zhang and Jiang-Jiang Qin
    Citation: Molecular Cancer 2022 21:70
  39. Esophageal squamous cell carcinoma (ESCC) is a common invasive malignancy worldwide with poor clinical outcomes. Increasing amount of long non-coding RNAs (lncRNAs) have been reported to be involved in cancer ...

    Authors: Song-tao Xue, Bin Zheng, Shi-qiang Cao, Jian-cheng Ding, Guo-sheng Hu, Wen Liu and Chun Chen
    Citation: Molecular Cancer 2022 21:69
  40. Resident microbial populations have been detected across solid tumors of diverse origins. Sequencing of the airway microbiota represents an opportunity for establishing a novel omics approach to early detectio...

    Authors: Erin A. Marshall, Fernando S. L. Filho, Don D. Sin, Stephen Lam, Janice M. Leung and Wan L. Lam
    Citation: Molecular Cancer 2022 21:68
  41. Degradation of targeted proteins using proteolysis targeting chimeras (PROTACs) has gained momentum. A PROTAC is a bifunctional molecule that consists of three parts: a ligand that interacts with the protein t...

    Authors: Cristina Nieto-Jiménez, Esther Cabañas Morafraile, Carlos Alonso-Moreno and Alberto Ocaña
    Citation: Molecular Cancer 2022 21:67

Annual Journal Metrics