Genome-wide analysis of the differentially methylated regions (DMRs) in primary glioma. (A) The numbers of DMRs associated with CpG islands (CGI). (B) The number of DMRs associated with, or without, genes. (C) The distribution of DMRs associated with genes. Most of the identified DMRs associated with genes were mapped to gene promoters. (D) The number of DMRs in the both gene promoters and CpG islands. (E) The chromosomal distribution of 216 promoter hypermethylated genes and 60 promoter hypomethylated genes.