Table 2 Function and pathway analysis of the promoter hypomethylated genes identified by MeDIP-chip
From: MiR-185 Targets the DNA Methyltransferases 1 and Regulates Global DNA Methylation in human glioma
Term | Promoter Hypomethylation Genes |
|---|---|
Go Term | |
signal transduction, cell communication | 14 genes:OR10G4, BAD, C9, OR51S1, CCRL2, OR8A1, SFN, ABR, OR1L6, FKBP8, DRD4, SORBS1, GP1BB, MLNR |
protein metabolic process, cellular metabolic process, biopolymer metabolic process | 11 genes: CPEB1, C9, NRBP2, PSMF1, OR51S1, KLHL21, FKBP8, TUBB4Q, PRSS33, FUT5, TUBB8 |
transport, ion channel activity, metal ion transport, cation transport | 10 genes:ACCN1, ABCC12, MFSD3, SLC28A1, SLC5A9, SLC2A9, KCNK4, TUBB4Q, TUBB8, SORBS1 |
hydrolase activity, serine hydrolase activity | 5 genes:ABCC12, OR51S1, TUBB4Q, PRSS33, TUBB8 |
regulation of gene expression,regulation of transcription,DNA binding,transcription factor activity | 5 genes: CPEB1,TOX2, LMO3, PHF13, NAT14 |
nervous system development, system development, organ development | 3 genes: IGSF8, ACCN1, ABR |
apoptotic program, induction of apoptosis, cell death | 3 genes: BAD, SFN, C9 |
KEGG_PATHWAY | |
Neuroactive ligand-receptor interaction | 3 genes: SCT, MLNR, DRD4 |
Insulin signaling pathway | 2 genes: BAD, SORBS1 |